Ubwino wa kalasi yamankhwala HPMC

HPMC hydroxypropyl methylcellulosewakhala mmodzi wa excipients waukulu mankhwala kunyumba ndi kunja, chifukwa HPMC ali ubwino kuti excipients ena alibe.

1. Kusungunuka kwamadzi

Imasungunuka m'madzi ozizira pansi pa 40 ℃ kapena 70% ethanol, ndipo imakhala yosasungunuka m'madzi otentha kuposa 60 ℃, koma imatha kupangidwanso.

2. Wopanga mankhwala

HPMC ndi mtundu wa non-ionic cellulose ether. Yankho lake silimanyamula ma ionic ndipo silimalumikizana ndi mchere wachitsulo kapena ma ionic organic compounds. Choncho, ena excipients sachita nawo pa kukonzekera ndondomeko.

3. Kukhazikika

Ndiwokhazikika ku asidi ndi zamchere, ndipo imatha kusungidwa kwa nthawi yayitali pakati pa pH 3 mpaka 11, ndipo kukhuthala kwake sikunasinthe. Yankho lamadzi la HPMC lili ndi anti-mildew ndipo limatha kukhalabe okhazikika pakasungidwe ka nthawi yayitali. Ma excipients ogwiritsira ntchito mankhwalaMtengo wa HPMCkukhala ndi kukhazikika kwabwinoko kuposa omwe amagwiritsa ntchito zopangira zachikhalidwe (monga dextrin, wowuma, etc.).

4. Kusintha kwa mamasukidwe akayendedwe

Osiyana mamasukidwe akayendedwe zotumphukira za HPMC akhoza kusakaniza mulingo wosiyana, ndi mamasukidwe akayendedwe ake akhoza kusintha malinga ndi lamulo linalake, ndipo ali ndi ubale wabwino liniya, kotero izo zikhoza kusankhidwa malinga ndi kufunika. 2.5 Metabolic inertia HPMC si odzipereka kapena zimapukusidwa mu thupi, ndipo sapereka zopatsa mphamvu, choncho ndi otetezeka excipient kwa mankhwala. .

5. Chitetezo

Nthawi zambiri zimaganiziridwa kutiMtengo wa HPMCndi zinthu zopanda poizoni komanso zosakwiyitsa.

Pharmaceutical-grade HPMC ndi chinthu chofunikira kwambiri popanga kukonzekera kokhazikika komanso koyendetsedwa bwino. Ndi chithandizo chamankhwala chothandizidwa ndi boma pakufufuza ndi chitukuko, ndipo chikugwirizana ndi njira zachitukuko zomwe zimathandizidwa ndi ndondomeko ya dziko la mafakitale. Pharmaceutical-grade HPMC ndiye chinthu chachikulu chopangira makapisozi a chomera cha HPMC, chomwe chimawerengera zopitilira 90% za makapisozi a mbewu ya HPMC. Ma capsules opangidwa ndi zomera ali ndi ubwino wa chitetezo ndi ukhondo, kugwiritsidwa ntchito kwakukulu, palibe chiopsezo chogwirizanitsa, komanso kukhazikika kwakukulu, zomwe zimagwirizana ndi zomwe ogula amayembekezera. Zofunikira zachitetezo ndi ukhondo pazakudya ndi mankhwala ndi chimodzi mwazinthu zofunikira zowonjezera komanso zolowa m'malo mwa makapisozi a gelatin a nyama.