Hydroxypropyl methylcellulose (HPMC)bụ ihe na-abụghị ionic cellulose ether nke a na-ejikarị eme ihe na ihe owuwu ụlọ, ọgwụ, nri, ihe ịchọ mma na ubi mmepụta ihe ndị ọzọ. Ọ nwere ọtụtụ njirimara anụ ahụ mara mma, nke na-eme ka ọ rụọ ọrụ nke ọma na ngwa dị iche iche.
1. Ọdịdị na solubility
HPMC na-abụkarị ntụ ọcha ma ọ bụ na-acha ọcha, enweghị isi, enweghị ụtọ na nke anaghị egbu egbu. Enwere ike ịgbaze ya na mmiri oyi na ụfọdụ ihe mgbaze organic (dị ka ihe mgbaze agwakọta dị ka ethanol/mmiri na acetone/mmiri), ma ọ bụ ihe a na-adịghị ahụkebe na ethanol dị ọcha, ether na chloroform. N'ihi ọdịdị na-abụghị nke ionic, ọ gaghị enweta mmeghachi omume electrolytic na ngwọta mmiri ma ọ gaghị emetụta uru pH nke ukwuu.
2. Viscosity na rheology
HPMC aqueous ngwọta nwere ezigbo ndim na thixotropy. Ụdị AnxinCel®HPMC dị iche iche nwere viscosities dị iche iche, nke a na-ahụkarị bụ 5 ruo 100000 mPa·s (2% ngwọta mmiri, 20°C). Ngwọta ya na-egosipụta pseudoplasticity, ya bụ, ihe na-eme ka ọkpụkpụ na-egbuke egbuke, ma dị mma maka ihe ngosi ngwa dị ka mkpuchi, slurries, adhesives, wdg na-achọ ezigbo rheology.
3. Thermal gelation
Mgbe HPMC na-ekpo ọkụ na mmiri, nghọta nke ngwọta na-ebelata na gel na-etolite na okpomọkụ. Mgbe ọ dị jụụ, ọnọdụ gel ga-alaghachi na steeti ngwọta. Ụdị HPMC dị iche iche nwere okpomọkụ gel dị iche iche, n'ozuzu n'etiti 50 na 75°C. Ngwongwo a dị mkpa karịsịa na ngwa ndị dị ka ụlọ ngwa agha na capsules ọgwụ.
4. Ọrụ elu
N'ihi na ụmụ irighiri ihe HPMC nwere hydrophilic na hydrophobic dị iche iche, ha na-egosi ụfọdụ ọrụ elu ma nwee ike rụọ ọrụ emulsifying, gbasaa na nkwụsi ike. Dịka ọmụmaatụ, na mkpuchi na emulsions, HPMC nwere ike imeziwanye nkwụsi ike nke emulsion ma gbochie sedimentation nke ihe ndị dị na pigmenti.
5. Hygroscopicity
HPMC nwere ụfọdụ hygroscopicity ma nwee ike ịmịkọrọ mmiri na gburugburu iru mmiri. Ya mere, n'ime ngwa ụfọdụ, ekwesịrị itinye nlebara anya na nkwakọ ngwaahịa iji gbochie mmịpụta mmiri na agglomeration.
6. Ihe nkiri na-emepụta ihe
HPMC nwere ike ịmepụta ihe nkiri siri ike na nke doro anya, nke a na-ejikarị eme ihe na nri, ọgwụ (dị ka ihe mkpuchi) na mkpuchi. Dịka ọmụmaatụ, na ụlọ ọrụ ọgwụ, enwere ike iji ihe nkiri HPMC mee ihe dịka mkpuchi mbadamba iji melite nkwụsi ike ọgwụ na ntọhapụ nchịkwa.
7. Biocompatibility na nchekwa
HPMC adịghị egbu egbu na enweghị mmerụ ahụ, ahụ mmadụ nwere ike ime ya n'enweghị nsogbu, ya mere a na-eji ya na ngalaba ọgwụ na nri. Dị ka ihe mgbakwunye ọgwụ, a na-ejikarị emepụta mbadamba ihe na-adịgide adịgide, shells capsule, wdg.
8. pH kwụsie ike nke ngwọta
HPMC kwụsiri ike na pH nso nke 3 ruo 11, ọ naghị adị mfe imebi ma ọ bụ mee ka acid na alkali mee ya, yabụ enwere ike iji ya na sistemu kemịkalụ dị iche iche, dị ka ihe ụlọ, ngwaahịa kemịkalụ kwa ụbọchị na usoro ọgwụ.
9. Nguzogide nnu
Ihe ngwọta HPMC kwụsiri ike na nnu inorganic, ọ naghị adị ngwa ngwa ngwa ngwa ma ọ bụ na-adịghị arụ ọrụ n'ihi mgbanwe na ntinye ion, nke na-enyere ya aka ịnọgide na-arụ ọrụ nke ọma na ụfọdụ sistemu nwere nnu (dị ka ngwa ngwa ciment).
10. Nkwụsi ike okpomọkụ
AnxinCel®HPMC nwere ezigbo nkwụsi ike na gburugburu ebe okpomọkụ dị elu, mana ọ nwere ike wedata ma ọ bụ na-agbaji agba mgbe ekpughere ya na oke okpomọkụ ruo ogologo oge. Ọ ka nwere ike ịnọgide na-arụ ọrụ nke ọma n'ime ụfọdụ okpomọkụ (na-adịkarị n'okpuru 200 Celsius C), ya mere ọ dị mma maka ngwa nhazi okpomọkụ dị elu.
11. Chemical kwụsie ike
HPMCdịtụ kwụsiri ike na ìhè, oxidants na kemịkalụ nkịtị, ihe kemịkal mpụga adịghị emetụta ya ngwa ngwa. Ya mere, enwere ike iji ya na ngwaahịa ndị chọrọ nchekwa ogologo oge, dị ka ihe ụlọ na ọgwụ.
A na-eji Hydroxypropyl methylcellulose mee ihe n'ọtụtụ ụlọ ọrụ n'ihi oke solubility ya, ịgbatị, gelation thermal, ihe na-emepụta ihe nkiri na nkwụsi ike kemịkal. N'ime ụlọ ọrụ ihe owuwu, enwere ike iji ya mee ihe dị ka igwe simenti; na ụlọ ọrụ ọgwụ, a pụrụ iji ya mee ihe dị ka ihe na-emepụta ọgwụ; na ụlọ ọrụ nri, ọ bụ ihe mgbakwunye nri na-emekarị. Ọ bụ ihe ndị a pụrụ iche na-eme ka HPMC bụrụ ihe dị mkpa na-arụ ọrụ polymer.
Oge nzipu: Feb-10-2025