HEC (Hydroxyethyl cellulose)bụ polymer mmiri soluble nke a na-ejikarị eme ihe na nkwadebe ọgwụ. Ọ bụ ihe mmepụta nke cellulose, nwetara site na-emeghachi omume ethanolamine (etylene oxide) na cellulose. N'ihi na ọ dị mma solubility, nkwụsi ike, ikike ngbanwe viscosity na biocompatibility, HEC nwere ọtụtụ ngwa ngwa na mpaghara ọgwụ, karịsịa na mmepụta mmepụta ihe, nhazi ụdị usoro onunu ogwu na njikwa ntọhapụ ọgwụ.
1. Ihe ndị bụ isi nke HEC
HEC, dị ka cellulose gbanwetụrụ, nwere ihe ndị a bụ isi:
Mmiri solubility: AnxinCel®HEC nwere ike ịmepụta ngwọta viscous na mmiri, na solubility ya metụtara okpomọkụ na pH. Ngwongwo a na-eme ka a na-eji ya mee ihe n'ụdị usoro ọgwụgwọ dị iche iche dị ka ọnụ na ọnụ.
Biocompatibility: HEC adịghị egbu egbu na enweghị mgbakasị ahụ n'ime ahụ mmadụ ma dakọtara na ọtụtụ ọgwụ. Ya mere, a na-eji ya n'ụdị usoro onunu ogwu na-adịgide adịgide yana ụdị nchịkwa nchịkwa mpaghara.
Viscosity na-agbanwe agbanwe: Enwere ike imezi viscosity nke HEC site n'ịgbanwe ịdị arọ ya ma ọ bụ itinye uche ya, nke dị oke mkpa maka ịchịkwa ntọhapụ nke ọgwụ ọjọọ ma ọ bụ meziwanye nkwụsi ike nke ọgwụ.
2. Ngwa nke HEC na nkwadebe ọgwụ
Dị ka ihe dị mkpa dị mkpa na nkwadebe ọgwụ, HEC nwere ọtụtụ ọrụ. Ndị na-esonụ bụ mpaghara ngwa ngwa ya na nkwadebe ọgwụ.
2.1 Ngwa na nkwadebe ọnụ
N'ụdị usoro onunu ogwu, a na-ejikarị HEC na-emepụta mbadamba nkume, capsules na nkwadebe mmiri mmiri. Isi ọrụ ya gụnyere:
Ihe nchikota: Na mbadamba na granules, HEC nwere ike iji dị ka ihe nkedo ka mma jikọta akụkụ ọgwụ ma ọ bụ ntụ ntụ ọnụ iji hụ na ike na nkwụsi ike nke mbadamba nkume.
Njikwa ntọhapụ na-adịgide adịgide: HEC nwere ike nweta mmetụta ntọhapụ na-adịgide adịgide site na ịchịkwa ọnụego ntọhapụ nke ọgwụ ahụ. Mgbe ejiri HEC na ihe ndị ọzọ (dị ka polyvinyl pyrrolidone, carboxymethyl cellulose, wdg), ọ nwere ike ịgbatị oge ntọhapụ nke ọgwụ ahụ n'ime ahụ nke ọma, belata ugboro ole ọgwụ, ma melite nnabata onye ọrịa.
Thickener: N'ime nkwadebe ọnụ mmiri mmiri, AnxinCel®HEC dị ka onye na-ebu ibu nwere ike melite uto nke ọgwụ na nkwụsi ike nke ụdị usoro onunu ogwu.
2.2 Ngwa na nkwadebe n'elu
A na-eji HEC eme ihe n'ọtụtụ ebe na ude, ude, gels, lotions na nkwadebe ndị ọzọ, na-egwu ọtụtụ ọrụ:
Gel matrix: A na-ejikarị HEC eme ihe dị ka matrix maka gels, karịsịa na usoro nnyefe ọgwụ transdermal. Ọ nwere ike inye nkwụsi ike kwesịrị ekwesị ma mee ka oge obibi nke ọgwụ ahụ dị na akpụkpọ ahụ, si otú a na-eme ka ọ dịkwuo mma.
Viscosity na nkwụsi ike: Viscosity nke HEC nwere ike ime ka adhesion nke nkwadebe n'elu akpụkpọ ahụ dị elu ma gbochie ọgwụ ahụ ka ọ daa n'oge na-adịghị anya n'ihi ihe ndị dị n'èzí dị ka esemokwu ma ọ bụ ịsacha. Na mgbakwunye, HEC nwere ike melite nkwụsi ike nke creams na ointments ma gbochie stratification ma ọ bụ crystallization.
Nri mmanu na moisturizer: HEC nwere ezigbo ihe na-edozi ahụ ma nwee ike inye aka mee ka akpụkpọ ahụ dị nro ma gbochie nkụ, ya mere a na-ejikwa ya na ihe ndị na-edozi ahụ na ngwaahịa nlekọta anụ ahụ ndị ọzọ.
2.3 Ngwa na nkwadebe ophthalmic
Ngwa nke HEC na nkwadebe ophthalmic na-egosipụtakarị na ọrụ ya dị ka nrapado na mmanu:
Ophthalmic gels na eye drops: Enwere ike iji HEC dị ka ihe nrapado maka nkwadebe ophthalmic iji mee ka oge kọntaktị dị n'etiti ọgwụ na anya ma hụ na ọ na-aga n'ihu na ọgwụ ahụ. N'otu oge ahụ, viscosity ya nwekwara ike igbochi ọdịda anya ka ọ ghara ịla ngwa ngwa ma mee ka oge nkwụsị nke ọgwụ ahụ dịkwuo elu.
Mmanya mmanu: HEC nwere ezigbo hydration ma nwee ike inye mmanu na-aga n'ihu na ọgwụgwọ ọrịa anya dị ka anya akọrọ, na-ebelata ahụ erughị ala anya.
2.4 Ngwa na nkwadebe injection
A pụkwara iji HEC mee ihe n'ịkwadebe ụdị ọgwụgwọ injections, karịsịa n'ụdị injections na-eme ogologo oge na nkwadebe ntọhapụ. Isi ọrụ nke HEC na nkwadebe ndị a gụnyere:
Thickerer na stabilizer: n'ime injection,HECnwere ike ime ka viscosity nke ngwọta dịkwuo elu, belata ọsọ nrịba nke ọgwụ ahụ, ma kwalite nkwụsi ike nke ọgwụ ahụ.
Ịchịkwa ntọhapụ ọgwụ: Dị ka otu n'ime akụkụ nke usoro ntọhapụ ọgwụ na-akwado, HEC nwere ike ijikwa ọnụego ntọhapụ nke ọgwụ ahụ site n'ịmepụta akwa gel mgbe ịgba ọgwụ mgbochi, iji nweta nzube nke ọgwụgwọ ogologo oge.
3. Ọrụ HEC na usoro nnyefe ọgwụ
Site na mmepe nke teknụzụ ọgwụ, a na-eji HEC eme ihe n'ọtụtụ ebe na usoro nnyefe ọgwụ dị iche iche, ọkachasị n'akụkụ ndị na-ebu nano-ọgwụ, microspheres, na ndị na-ebugharị ọgwụ na-akwado. Enwere ike ijikọ HEC na ihe ndị na-ebu ọgwụ dị iche iche iji mepụta mgbagwoju anya siri ike iji hụ na ntọhapụ na-adịgide adịgide na nnyefe ọgwụ nke ọma.
Onye na-ebu ọgwụ Nano: Enwere ike iji HEC dị ka stabilizer maka ndị na-ebu ọgwụ nano iji gbochie nchịkọta ma ọ bụ mmiri ozuzo nke ihe ndị na-ebu ibu ma na-abawanye bioavailability nke ọgwụ.
Microspheres na ụmụ irighiri ihe: Enwere ike iji HEC kwadebe microspheres na ndị na-ebu ọgwụ microparticle iji hụ na mwepụta ọgwụ na-adị ngwa ngwa n'ime ahụ ma melite nrụpụta ọgwụ.
Dị ka a multifunctional na ịrụ ọrụ nke ọma ọgwụ excipient, AnxinCel®HEC nwere sara mbara ngwa atụmanya na nkwadebe ọgwụ. Site na mmepe nke teknụzụ ọgwụ na-aga n'ihu, HEC na-arụ ọrụ dị mkpa na njikwa ntọhapụ ọgwụ, nchịkwa mpaghara, nkwado ntọhapụ na usoro nnyefe ọgwụ ọhụrụ. Ya dị mma biocompatibility, viscosity na-agbanwe agbanwe na nkwụsi ike na-eme ka ọ bụrụ nke a na-apụghị dochie anya na ngalaba ọgwụ. N'ọdịnihu, na ọmụmụ ihe omimi nke HEC, ngwa ya na nkwadebe ọgwụ ga-adịwanye ukwuu ma dị iche iche.
Oge nzipu: Dec-28-2024