Hydroxypropylmethylcellulose (HPMC) bụ polima a na-ejikarị eme ihe n'ọtụtụ ụlọ ọrụ dị iche iche n'ihi ihe pụrụ iche o nwere. Ihe mejupụtara ya bụ ihe sitere na cellulose, polima eke a na-ahụ na mgbidi mkpụrụ osisi. Mmepụta nke HPMC gụnyere iji propylene oxide gwọọ cellulose iji webata otu hydroxypropyl yana methyl chloride iji webata otu methyl. Polima a na-enweta na-egosipụta ọtụtụ ihe onwunwe anụ ahụ na kemịkalụ, na-eme ka ọ dabara adaba maka ojiji na ọgwụ, owuwu, nri na ụlọ ọrụ ndị ọzọ.
1. Nhazi na nhazi kemịkalụ:
Hydroxypropyl methylcellulose bụ polima semi-synthetic nwere nhazi kemịkalụ dị mgbagwoju anya. Ọkpụkpụ azụ nke polima ahụ nwere cellulose, usoro kwụ ọtọ nke molekul glucose jikọtara ya na njikọ β-1,4-glycosidic. A na-ewebata otu hydroxypropyl site na iji otu propyl dochie otu hydroxyl (-OH), a na-ewebatakwa otu methyl n'otu ụzọ ahụ. Ogo nke nnọchi (DS) na-anọchite anya ọnụọgụgụ nke otu hydroxypropyl na methyl kwa otu glucose ma na-emetụta ike ịgbaze, viscosity, na ihe onwunwe okpomọkụ nke polima ahụ.
2. Mmiri na-agbaze:
Otu n'ime ihe pụrụ iche nke HPMC bụ àgwà ya nke ịgbaze. Ọ na-agbaze ma na mmiri oyi ma na-ekpo ọkụ, na-enye uru pụrụ iche n'ọtụtụ ojiji. Enwere ike ịgbanwe ike ịgbaze site na ịgbanwe ogo nnọchi na ibu molekul nke polima ahụ. Ihe onwunwe a na-eme ka HPMC bụrụ ezigbo onye na-achọ sistemụ nnyefe ọgwụ a na-achịkwa, ebe ọnụego mgbaze na-arụ ọrụ dị mkpa na kinetics ntọhapụ ọgwụ.
3. Viscositi:
A na-enweta Hydroxypropyl methylcellulose n'ọtụtụ ọkwa viscosity dị iche iche, dabere na ihe ndị dị ka ibu molekul, ogo nnọchi, na ntinye nke ngwọta. viscosity nke ngwọta HPMC na-enye ohere iji ha mee ihe n'ọtụtụ ngwa ụlọ ọrụ mmepụta ihe, gụnyere ọgwụ, dị ka ihe na-eme ka ihe sie ike n'ụdị ọgwụ mmiri mmiri, yana dị ka ihe na-emepụta fim maka mkpuchi.
4. Ọrụ nhazi ihe nkiri:
Ike imepụta ihe nkiri nke HPMC dị oke mkpa n'ọrụ dịka mkpuchi ọgwụ, ebe a na-eji ya enye ihe nchekwa iji kpuchie uto ọgwụ, chịkwaa mwepụta ọgwụ, ma melite nkwụsi ike. Ihe nkiri HPMC doro anya ma na-agbanwe agbanwe, enwere ike ịhazi ihe onwunwe ha site na ịgbanwe mkpokọta polymer, ibu molekul na ọdịnaya plastik.
5. Arụmọrụ okpomọkụ:
Hydroxypropyl methylcellulose na-egosipụta ezigbo nkwụsi ike okpomọkụ n'ime oke okpomọkụ akọwapụtara. Ihe ndị dị ka ogo nnọchi, ibu molekul, na ọnụnọ nke ihe ndị na-eme ka plastik dị na ya na-emetụta ihe ndị dị na okpomọkụ. Ihe ndị a na-eme ka HPMC dabara adaba maka ojiji ebe nkwụsi ike okpomọkụ dị oke mkpa, dịka nkwadebe nke ọgwụ ndị na-emetụta okpomọkụ.
6. Ndakọrịta nke ihe ndị dị ndụ:
N'ihe gbasara ọgwụ na ọgwụ, njikọta bio bụ ihe dị mkpa a ga-atụle maka ihe eji eme ihe na sistemụ nnyefe ọgwụ. A na-ewerekarị Hydroxypropyl methylcellulose dị ka ihe dị mma ma nwee ezigbo njikọta bio. A na-ejikarị ya eme ihe n'ịhazi ụdị ọgwụ a na-aṅụ, ngwọta anya na sistemụ nnyefe ọgwụ a na-achịkwa.
7. Njirimara idobe mmiri na ime ka ọ sie ike:
Ike HPMC nwere ijigide mmiri na ihe ngwọta dị arọ na-eme ka ọ baa uru n'ihe owuwu dịka ngwaahịa ndị e ji simenti mee. N'ọrụ ndị a, HPMC na-arụ ọrụ dị ka ihe na-ejide mmiri, na-eme ka usoro nhazi dịkwuo mma ma na-egbochi nkụchi ihe ahụ n'oge. A na-ejikwa ihe ndị na-eme ka ihe sie ike n'ọtụtụ ngwaahịa nri iji mee ka udidi na mmetụta ọnụ dịkwuo mma.
8. Nnyefe ọgwụ a na-achịkwa achịkwa:
Otu n'ime ihe dị mkpa e ji hydroxypropyl methylcellulose mee bụ imepụta usoro nnyefe ọgwụ a na-achịkwa achịkwa. Ọdịdị ya nke polymer na-agbaze, viscosity, na ihe ndị na-emepụta ihe nkiri na-eme ka mwepụta ọgwụ dịkwuo mfe, na-eme ka nnyefe ọgwụ na-aga n'ihu ma na-elekwasị anya. Nke a bara uru karịsịa maka imeziwanye nrubeisi nke ndị ọrịa na ibelata mmetụta ọjọọ ndị metụtara mwepụta ọgwụ ngwa ngwa.
9. Ịkwụsi ike n'okpuru gburugburu pH dị iche iche:
HPMC na-egosipụta nkwụsi ike n'elu oke pH dị iche iche, nke na-eme ka ọ dabara adaba maka usoro ndị chọrọ nkwụsi ike n'okpuru ọnọdụ acidic ma ọ bụ alkaline. Ihe onwunwe a bara uru na ọgwụ n'ihi na usoro ọgwụ nwere ike izute gburugburu pH dị iche iche na tract eriri afọ.
10. Njirimara rheological:
Omume rheological nke ngwọta HPMC dị oke mkpa maka ngwa ebe njirimara mmiri dị oke mkpa, dịka n'ịkwadebe mkpuchi, ihe nrapado na gels. Enwere ike ịhazi njirimara rheological site na ịgbanwe mkpokọta na ibu molekul nke HPMC iji nweta njirimara mmiri achọrọ maka njikwa e-njikwa kpọmkwem.
Hydroxypropyl methylcellulose aghọọla polima dị mkpa n'ọtụtụ ụlọ ọrụ n'ihi njikọta pụrụ iche ya nke ịgbaze, viscosity, ikike imepụta ihe nkiri na biocompatibility. Njikere ya dị iche iche na-eme ka ọ dabara adaba maka ọtụtụ ojiji, site na ọgwụ na ihe owuwu ruo na nri na ihe ịchọ mma. Ka ndị nchọpụta na-aga n'ihu na-enyocha usoro na ojiji ọhụrụ, ihe onwunwe nke hydroxypropyl methylcellulose ga-enye aka na ọganihu n'ọtụtụ ngalaba, na-eme ka ọ dị mkpa na sayensị na ụlọ ọrụ ihe.
Oge ozi: Jenụwarị-10-2024