Hydroxypropyl Methylcellulose (HPMC) bụ ihe e ji emepụta cellulose nke a na-ejikarị eme ihe, nke nwere ọtụtụ ihe dị iche iche dịka ọgwụ, nri, ihe owuwu ụlọ na ihe ịchọ mma. HPMC bụ polima na-abụghị ionic, semi-synthetic, nke na-anaghị agbanwe agbanwe, nke nwere ezigbo mmiri na-agbaze, na-eme ka ọ sie ike, na-arapara na ihe ndị na-emepụta ihe nkiri.
Nhazi na Njirimara nke HPMC
HPMC bụ cellulose agbanwere agbanwe nke a na-emepụta site na iji cellulose na-emeghachi omume na methyl chloride na propylene oxide. Nhazi molekul ya nwere ma ihe ndị na-anọchi methyl na hydroxypropyl, nke na-enye HPMC ihe pụrụ iche nke anụ ahụ na kemịkalụ, dị ka ịgbaze dị mma, nchebe colloid na ihe ndị na-emepụta ihe nkiri. Enwere ike kewaa HPMC n'ọtụtụ nkọwapụta dịka ihe ndị na-anọchi dị iche iche si dị, nkọwapụta ọ bụla nwekwara ike ịgbaze na ojiji dị iche iche na mmiri.
Mmiri nke HPMC n'ime mmiri
Usoro mgbaze
HPMC na-emekọrịta ihe na molekul mmiri site na njikọ hydrogen iji mepụta ngwọta. Usoro mgbaze ya gụnyere molekul mmiri na-abanye nwayọ nwayọ n'etiti agbụ molekul nke HPMC, na-ebibi njikọ ya, ka agbụ polymer wee gbasaa n'ime mmiri iji mepụta ngwọta otu. Mgbaze nke HPMC nwere njikọ chiri anya na ibu molekul ya, ụdị nnọchi na ogo nnọchi (DS). N'ozuzu, ka ọkwa nnọchi nke nnọchi nke nnọchi dị elu, otú ahụ ka ike HPMC na-agbaze elu na mmiri.
Mmetụta nke okpomọkụ na mgbaze
Okpomọkụ bụ otu n'ime ihe ndị dị mkpa na-emetụta ike ịgbaze nke HPMC. Ike ịgbaze nke HPMC n'ime mmiri na-egosi njirimara dị iche iche ka okpomọkụ na-agbanwe:
Oke okpomọkụ nke mmiri na-agbaze: Ọ na-esiri ike ịgbaze HPMC na mmiri oyi (n'ozuzu ya na-erughị 40°C), mana ọ nwere ike ịgbaze ngwa ngwa mgbe e tinyere ya ọkụ ruo 60°C ma ọ bụ karịa. Maka obere viscosity nke mmiri na-agbaze, okpomọkụ mmiri nke dị ihe dịka 60°C na-abụkarị okpomọkụ kachasị mma maka ịgbaze. Maka HPMC nke na-agbaze nke ọma, oke okpomọkụ kachasị mma nwere ike ịdị elu ruo 80°C.
Gelation n'oge oyi: Mgbe a na-ekpo ọkụ mmiri HPMC ruo okpomọkụ ụfọdụ (nke na-abụkarị 60-80°C) n'oge a na-agbaze ma jiri nwayọọ nwayọọ jụọ oyi, a ga-emepụta jel okpomọkụ. Jel okpomọkụ a na-adịgide mgbe ọ jụrụ oyi ruo okpomọkụ ụlọ ma enwere ike ịgbasa ya ọzọ na mmiri oyi. Ihe a dị oke mkpa maka nkwadebe mmiri HPMC maka ebumnuche ụfọdụ (dịka mkpụrụ ọgwụ ndị na-adịgide adịgide).
Arụmọrụ nke ịgbaze: N'ozuzu, okpomọkụ dị elu nwere ike ime ka usoro ịgbaze nke HPMC dị ngwa. Agbanyeghị, oke okpomọkụ nwekwara ike ibute mmebi nke polymer ma ọ bụ mbelata na viscosity nke ịgbaze. Ya mere, n'ọrụ n'ezie, a ga-ahọrọ okpomọkụ ịgbaze kwesịrị ekwesị dịka ọ dị mkpa iji zere mmebi na-enweghị isi na mgbanwe ihe onwunwe.
Mmetụta nke pH na mgbaze
Dịka polima na-abụghị ionic, ike ịgbaze nke HPMC n'ime mmiri anaghị emetụta kpọmkwem site na uru pH nke ngwọta ahụ. Agbanyeghị, ọnọdụ pH dị oke njọ (dịka gburugburu acidic ma ọ bụ alkaline siri ike) nwere ike imetụta njirimara ịgbaze nke HPMC:
Ọnọdụ asịd: N'okpuru ọnọdụ asịd siri ike (pH < 3), ụfọdụ njikọ kemịkalụ nke HPMC (dịka njikọ ether) nwere ike ibibi site na ihe na-esi na acid eme ihe, si otú a na-emetụta ike ịgbaze ya na ike ịgbaze ya. Agbanyeghị, n'ime oke asịd adịghị ike (pH 3-6), HPMC ka nwere ike ịgbaze nke ọma. Ọnọdụ alkaline: N'okpuru ọnọdụ alkaline siri ike (pH > 11), HPMC nwere ike ịgbaze, nke na-abụkarị n'ihi mmeghachi omume hydrolysis nke yinye hydroxypropyl. N'okpuru ọnọdụ alkaline adịghị ike (pH 7-9), ike ịgbaze nke HPMC anaghị emetụta nke ukwuu.
Usoro mgbaze nke HPMC
Iji gbazee HPMC nke ọma, a na-ejikarị usoro ndị a eme ihe:
Usoro mgbasa mmiri oyi: Tinye ntụ ntụ HPMC nwayọ nwayọ n'ime mmiri oyi ka ị na-akpali ya ka ọ gbasaa nke ọma. Usoro a nwere ike igbochi HPMC ịchịkọta ozugbo na mmiri, ihe ngwọta ahụ na-emepụta oyi akwa nchekwa colloidal. Mgbe ahụ, kpoo ya nwayọ nwayọ ruo 60-80°C iji gbazee ya kpamkpam. Usoro a dabara adaba maka ịgbaze ọtụtụ HPMC.
Usoro mgbasa mmiri ọkụ: Tinye HPMC na mmiri ọkụ ma gwakọta ya ngwa ngwa ka ọ gbazee ngwa ngwa na okpomọkụ dị elu. Usoro a dabara adaba maka HPMC nke na-agbaze nke ukwuu, mana a kwesịrị ilekwasị anya n'ịchịkwa okpomọkụ iji zere mmebi.
Usoro nkwadebe tupu a kwadebe ngwọta: Nke mbụ, a na-agbaze HPMC na ihe mgbaze organic (dịka ethanol), wee tinye mmiri nwayọ nwayọ iji gbanwee ya ka ọ bụrụ mmiri mmiri. Usoro a dabara adaba maka ọnọdụ pụrụ iche nke enwere ike ịgbaze nke ọma.
Omume mgbaze na ngwa bara uru
N'ọrụ bara uru, usoro mgbasa nke HPMC kwesịrị ịdị mma dịka ojiji akọwapụtara si dị. Dịka ọmụmaatụ, n'ọhịa ọgwụ, ọ na-adịkarị mkpa ịmepụta ngwọta colloidal dị otu ma kwụsie ike, a na-ejikwa okpomọkụ na pH nke ọma iji hụ na mmiri na-agbaze na ọrụ bayoloji nke ngwọta ahụ. N'ihe owuwu ụlọ, mmiri nke HPMC na-emetụta ihe ndị na-emepụta fim na ike nrụgide, yabụ a ga-ahọrọ ụzọ mgbasa kacha mma yana ọnọdụ gburugburu ebe obibi kpọmkwem.
Ọtụtụ ihe na-emetụta otú HPMC si agbaze n'ime mmiri, ọkachasị okpomọkụ na pH. N'ikwu ya n'ozuzu, HPMC na-agbaze ngwa ngwa na okpomọkụ dị elu (60-80°C), mana ọ nwere ike imebi ma ọ bụ ghara ịgbaze nke ọma n'okpuru ọnọdụ pH dị oke njọ. Ya mere, n'ọrụ bara uru, ọ dị mkpa ịhọrọ oke okpomọkụ na oke pH kwesịrị ekwesị dịka ojiji na ọnọdụ gburugburu ebe obibi nke HPMC si dị iji hụ na ọ nwere ike ịgbaze nke ọma ma rụọ ọrụ nke ọma.
Oge ozi: Juun-25-2024