Kedu pH ka HPMC na-agbaze

Hydroxypropyl methylcellulose (HPMC)bụ polima a na-ejikarị eme ihe n'ọgwụ, ihe ịchọ mma, na ngwaahịa nri. Ọ na-agbaze agbaze dabere na ihe dị iche iche, gụnyere pH. N'ozuzu, HPMC na-agbaze agbaze ma n'ọnọdụ acidic ma alkaline, mana ọ na-agbaze agbaze nwere ike ịdị iche dabere na oke nnọchi (DS) na oke molekul (MW) nke polima ahụ.

N'ọnọdụ acidic, HPMC na-egosipụtakarị ezigbo mgbaze n'ihi protonation nke otu hydroxyl ya, nke na-eme ka mmiri ya na ịgbasa na ịgbasa ya dịkwuo mma. Mgbaze nke HPMC na-abawanye ka pH na-ebelata n'okpuru pKa ya, nke dị ihe dịka 3.5–4.5 dabere na oke nnọchi ya.

N'aka nke ọzọ, n'ọnọdụ alkaline, HPMC nwekwara ike ịgbaze, ọkachasị na ọkwa pH dị elu. Na pH alkaline, mwepụ nke otu hydroxyl na-eme, na-eduga na mmụba nke ịgbaze site na njikọ hydrogen na molekul mmiri.

Agbanyeghị, ọ dị mkpa ịmara na pH kpọmkwem nke HPMC na-agbaze nwere ike ịdị iche dabere na ọkwa kpọmkwem nke HPMC, ogo nnọchi ya, na ibu molekul ya. Dịka ọ na-adịkarị, HPMC na-enye ọkwa dị elu nke nnọchi na obere ibu molekul na-egosipụta ike ịgbaze nke ọma na ụkpụrụ pH dị ala.

N'ime ọgwụ ndị e ji eme ihe,HPMCA na-ejikarị ya eme ihe dị ka ihe e ji ihe nkiri mee, ihe na-eme ka ọ sie ike, ma ọ bụ ihe na-eme ka ọ sie ike. Àgwà ya dị oke mkpa maka ijikwa profaịlụ mwepụta ọgwụ, viscosity nke usoro, na nkwụsi ike nke emulsions ma ọ bụ nkwusioru.

Ọ bụ ezie na HPMC na-agbaze n'ọtụtụ ebe n'ọtụtụ pH, enwere ike idozi àgwà ịgbaze ya site na ịgbanwe pH nke ngwọta ahụ ma họrọ ọkwa kwesịrị ekwesị nke HPMC dabere na ngwa achọrọ.