Hydroxypropyl methylcellulose (HPMC)yog ib qho kev siv cellulose derivative nrog ntau yam kev siv, tshwj xeeb tshaj yog nyob rau hauv kev lag luam tshuaj, tshuaj pleev ib ce, khoom noj khoom haus, thiab cov khoom siv hauv tsev. Nws tsis yog cov kuab tshuaj, tab sis cov dej-soluble polymer uas tuaj yeem yaj hauv dej thiab tsim cov kua dej ntshiab colloidal. Lub solubility ntawm AnxinCel®HPMC nyob ntawm tus naj npawb thiab txoj haujlwm ntawm methyl thiab hydroxypropyl substituents hauv nws cov qauv molecular.
1. Cov khoom tseem ceeb ntawm hydroxypropyl methylcellulose
Hydroxypropyl methylcellulose yog tau los ntawm methylation thiab hydroxypropylation ntawm cellulose. Cellulose nws tus kheej yog lub ntuj molecular polysaccharide uas muaj nyob rau hauv cov nroj tsuag cell phab ntsa. Cov qauv tshuaj ntawm HPMC feem ntau yog tsim los ntawm cov piam thaj, uas yog cov saw hlau ntev txuas nrog β-1,4 glycosidic bonds. Hauv cov qauv molecular no, qee pawg hydroxyl tau hloov los ntawm methyl (-OCH₃) thiab hydroxypropyl (-C₃H₇OH), muab nws zoo solubility thiab lwm yam khoom siv lub cev thiab tshuaj.
Lub solubility ntawm HPMC cuam tshuam los ntawm cov qauv molecular thiab feem ntau muaj cov yam ntxwv hauv qab no:
Dej solubility: HPMC tuaj yeem tsim cov kua dej khov hauv dej thiab yaj sai sai. Nws solubility yog ze ze rau qhov kub ntawm dej thiab molecular hnyav ntawm HPMC.
High viscosity: Ntawm ib qho concentration, cov tshuaj HPMC qhia tau hais tias muaj viscosity ntau dua, tshwj xeeb tshaj yog nyob rau hauv siab molecular hnyav thiab siab concentration.
Thermal stability: HPMC muaj kev ruaj ntseg zoo ntawm qee qhov kub thiab tsis yooj yim rau decompose, yog li nws muaj qee qhov zoo hauv cov txheej txheem thermal.
2. Solubility ntawm HPMC
HPMC yog cov dej-soluble, tab sis nws tsis yog yaj los ntawm tag nrho cov kuab tshuaj. Nws tus cwj pwm dissolution muaj feem xyuam nrog lub polarity ntawm cov kuab tshuaj thiab kev cuam tshuam ntawm cov kuab tshuaj molecules thiab HPMC molecules.
Dej: HPMC tuaj yeem yaj hauv dej. Dej yog nws cov kuab tshuaj ntau tshaj plaws, thiab thaum lub sij hawm dissolution txheej txheem, AnxinCel®HPMC molecules yuav tsim hydrogen bonds nrog dej molecules kom tiav dissolution. Lub degree ntawm dissolution yog cuam tshuam los ntawm tej yam xws li molecular luj ntawm HPMC, lub degree ntawm methylation thiab hydroxypropylation, kub, thiab pH tus nqi ntawm cov dej. Feem ntau, kev solubility ntawm HPMC yog qhov zoo tshaj plaws nyob rau hauv nruab nrab pH ib puag ncig.
Organic kuab tshuaj: HPMC yuav luag insoluble nyob rau hauv feem ntau cov organic solvents, xws li cawv, ethers, thiab hydrocarbons. Qhov no yog vim nws cov qauv molecular muaj hydrophilic hydroxyl pawg thiab lipophilic methyl thiab hydroxypropyl pawg. Txawm hais tias nws muaj kev sib raug zoo rau dej, nws muaj kev sib raug zoo nrog feem ntau cov kuab tshuaj organic.
Cov dej kub solubility: Hauv dej sov (feem ntau yog 40 ° C txog 70 ° C), HPMC yaj sai sai thiab cov kua dej yaj ua rau muaj viscosity siab. Raws li qhov kub thiab txias ntxiv, qhov sib tov thiab solubility yuav nce, tab sis thaum kub heev, cov viscosity ntawm cov tshuaj yuav cuam tshuam.
3. Kev siv HPMC
Vim nws cov dej zoo solubility, tsis tshua muaj toxicity, thiab adjustable viscosity, HPMC yog dav siv nyob rau hauv ntau yam lag luam.
Kev lag luam kws tshuaj: Hauv kev lag luam kws tshuaj, HPMC tau siv dav hauv kev npaj cov tshuaj, tshuaj molding, gels, thiab cov nqa tshuaj. Nws tuaj yeem pab cov tshuaj kom ruaj khov hauv dej thiab tswj tus nqi ntawm cov tshuaj tso tawm.
Kev lag luam khoom noj khoom haus: HPMC, raws li cov khoom noj ntxiv, feem ntau yog siv rau emulsification, thickening, thiab moisturizing. Hauv cov khoom ci, nws tuaj yeem txhim kho ductility thiab stability ntawm mov paj. HPMC kuj tseem siv tau rau hauv cov dej khov nab kuab, dej haus thiab cov khoom noj muaj roj tsawg.
Kev tsim kho kev lag luam: Hauv kev tsim kho kev lag luam, HPMC feem ntau yog siv los ua cov nplaum rau lub tsev mortar, uas tuaj yeem txhim kho kev tsim kho, kev tuav dej thiab kev sib koom ua ke ntawm mortar.
Tshuaj pleev ib ce: Hauv cov tshuaj pleev ib ce, AnxinCel®HPMC feem ntau yog siv los ua cov thickener, suspending agent thiab stabilizer, thiab yog dav siv nyob rau hauv cov khoom xws li lub ntsej muag cream, tshuaj zawv plaub hau, thiab da dej gels.
HPMCyog ib qho dej-soluble thiab viscous cellulose derivative uas tuaj yeem tsim cov pob tshab colloidal hauv dej. Nws tsis yog cov kuab tshuaj, tab sis muaj cov tshuaj molecular siab uas tuaj yeem yaj hauv dej. Nws solubility yog manifested nyob rau hauv zoo solubility nyob rau hauv dej, tab sis insoluble nyob rau hauv feem ntau cov organic solvents. Cov yam ntxwv ntawm HPMC no ua rau nws siv dav hauv ntau lub lag luam, suav nrog tshuaj, khoom noj, kev tsim kho, thiab tshuaj pleev ib ce.
Post lub sij hawm: Feb-17-2025