Hydroxypropyl Methylcellulose (HPMC)he ʻano kemika i hoʻololi ʻia o cellulose i hoʻohana nui ʻia i nā ʻano ʻoihana like ʻole e like me ka lāʻau lapaʻau, ka hana meaʻai, a me ke kūkulu ʻana. He mea maʻalahi ia, hoʻohana pinepine ʻia e like me kahi mānoanoa, binder, mea hana kiʻiʻoniʻoni, a me ka stabilizer. Akā naʻe, ʻaʻohe ona "huahelu serial" kikoʻī ma ke ʻano kuʻuna, e like me kahi huahana a i ʻole helu hapa āu e ʻike ai ma nā ʻano hana ʻē aʻe. Akā, ʻike ʻia ʻo HPMC e kona ʻano kemika a me kekahi mau hiʻohiʻona, e like me ke ʻano o ka hoʻololi a me ka viscosity.
ʻIkepili Nui e pili ana i ka Hydroxypropyl Methylcellulose (HPMC)
Hana Kemika: Hana ʻia ka HPMC ma o ka hoʻololi ʻana i ka cellulose ma o ka hoʻololi ʻana i nā pūʻulu hydroxyl (-OH) me nā hui hydroxypropyl a me methyl. Hoʻololi ka hoʻololi ʻana i nā waiwai o cellulose, e hoʻoheheʻe ʻia i ka wai a hāʻawi iā ia i kāna mau waiwai kūʻokoʻa e like me ka hoʻomaikaʻi ʻana i ka hiki ke hana kiʻiʻoniʻoni, hiki ke hoʻopaʻa, a me ka hiki ke mālama i ka makū.
Nā mea hōʻike maʻamau a me ka inoa inoa
ʻO ka ʻike ʻana o Hydroxypropyl Methylcellulose e hilinaʻi maʻamau i nā ʻano inoa inoa like ʻole e wehewehe ana i kona ʻano kemika a me nā waiwai.
Helu CAS:
Hāʻawi ka Chemical Abstracts Service (CAS) i kahi ʻike kūʻokoʻa i kēlā me kēia mea kemika. ʻO ka helu CAS no Hydroxypropyl Methylcellulose he 9004-65-3. He helu maʻamau kēia i hoʻohana ʻia e nā chemists, nā mea hoʻolako, a me nā kino hoʻoponopono e kuhikuhi i ka mea.
Nā Code InChI a me SMILES:
ʻO InChI (International Chemical Identifier) kekahi ala e hōʻike ai i ke ʻano kemika o kahi mea. Loaʻa iā HPMC kahi kaula InChI lōʻihi e hōʻike ana i kona ʻano molekala ma kahi ʻano maʻamau.
ʻO SMILES (Simplified Molecular Input Line Entry System) he ʻōnaehana ʻē aʻe i hoʻohana ʻia e hōʻike i nā molekala ma kahi ʻano kikokikona. Loaʻa iā HPMC kahi code SMILES e pili ana, ʻoiai he paʻakikī loa ia ma muli o ke ʻano nui a loli o kona ʻano.
Nā kikoʻī o ka huahana:
Ma ka mākeke kalepa, ʻike pinepine ʻia ka HPMC e nā helu huahana, hiki ke hoʻololi ʻia e ka mea hana. No ka laʻana, loaʻa paha i kahi mea hoʻolako kahi māka e like me HPMC K4M a i ʻole HPMC E15. Hoʻomaopopo pinepine kēia mau mea ʻike i ka viscosity o ka polymer i ka hopena, i hoʻoholo ʻia e ke degere o ka methylation a me ka hydroxypropylation a me ke kaumaha mole.
Nā māka maʻamau o Hydroxypropyl Methylcellulose (HPMC)
ʻOkoʻa nā ʻano o ka Hydroxypropyl Methylcellulose ma muli o ke ʻano o ka hoʻololi ʻana o nā pūʻulu methyl a me hydroxypropyl, a me ke kaumaha mole. Hoʻoholo kēia mau ʻokoʻa i ka viscosity a me ka solubility o ka HPMC i ka wai, a laila pili i kāna mau noi ma nā ʻoihana like ʻole.
Aia ma lalo kahi papa e wehewehe ana i nā māka like ʻole o Hydroxypropyl Methylcellulose:
| Papa | Viscosity (cP i 2% solution) | Nā noi | wehewehe |
| HPMC K4M | 4000 – 6000 cP | Mea hoʻopaʻa papa lāʻau lapaʻau, ʻoihana meaʻai, hana (nā mea hoʻopili) | Medium viscosity grade, hoʻohana mau ʻia i ka hoʻohua ʻana i ka papa waha. |
| HPMC K100M | 100,000 – 150,000 cP | Hoʻopuka hoʻokuʻu ʻia i nā lāʻau lapaʻau, hana, a me nā uhi pena | ʻO ka viscosity kiʻekiʻe, maikaʻi loa no ka hoʻokuʻu ʻana i nā lāʻau lapaʻau. |
| HPMC E4M | 3000 – 4500 cP | ʻO nā mea hoʻonani, nā hale lole, ka hana ʻana i nā meaʻai, nā mea hoʻopili, a me nā uhi | Hiki ke hoʻoheheʻe ʻia i ka wai anuanu, hoʻohana ʻia i nā huahana mālama pilikino a me nā meaʻai. |
| HPMC E15 | 15,000 cP | Mānoanoa i loko o nā pena, ka uhi, ka meaʻai, a me nā lāʻau lapaʻau | ʻO ka viscosity kiʻekiʻe, hiki ke hoʻoheheʻe ʻia i ka wai anuanu, hoʻohana ʻia i nā huahana ʻoihana a me nā lāʻau lapaʻau. |
| HPMC M4C | 4000 – 6000 cP | ʻO ka ʻoihana meaʻai a me ka mea inu ma ke ʻano he stabilizer, lāʻau lapaʻau ma ke ʻano he binder | ʻO ka viscosity haʻahaʻa, hoʻohana pinepine ʻia ma ke ʻano he mānoanoa i ka meaʻai i hana ʻia. |
| HPMC 2910 | 3000 – 6000 cP | ʻO nā mea hoʻonaninani (nā ʻilima, nā lotions), nā meaʻai (mea ʻono), nā lāʻau lapaʻau (capsules, coatings) | ʻO kekahi o nā māka maʻamau, hoʻohana ʻia ma ke ʻano he mea hoʻopaʻa a me ka mānoanoa. |
| HPMC 2208 | 5000 – 15000 cP | Hoʻohana ʻia i ka hana sima a me ka plaster, textiles, nā uhi pepa | Maikaʻi no nā noi e koi ana i nā waiwai hana kiʻiʻoniʻoni maikaʻi loa. |
Hoʻohui kikoʻī a me nā waiwai o HPMC
ʻO nā waiwai kino o Hydroxypropyl Methylcellulose e hilinaʻi nui i ka nui o ka hoʻololi ʻana o nā pūʻulu hydroxyl i loko o ka mole cellulose. Eia nā waiwai nui:
Degree of Substitution (DS):
E pili ana kēia i ka nui o nā pūʻulu hydroxyl i cellulose i pani ʻia e nā hui methyl a hydroxypropyl paha. ʻO ke kiʻekiʻe o ka hoʻololi ʻana e pili ana i ka solubility o HPMC i loko o ka wai, kona viscosity, a me kona hiki ke hana i nā kiʻiʻoniʻoni. ʻO ka DS maʻamau no HPMC mai ka 1.4 a i ka 2.2, ma muli o ka papa.
Viscosity:
Hoʻokaʻawale ʻia nā māka HPMC ma muli o ko lākou viscosity ke hoʻoheheʻe ʻia i ka wai. ʻO ke kiʻekiʻe o ke kaumaha molekala a me ke kiʻekiʻe o ka hoʻololi ʻana, ʻoi aku ka kiʻekiʻe o ka viscosity. No ka laʻana, hoʻohana pinepine ʻia ʻo HPMC K100M (me ka laulā viscosity kiʻekiʻe) i nā ʻano lāʻau lapaʻau hoʻokuʻu ʻia, akā hoʻohana mau ʻia nā māka viscosity haʻahaʻa e like me HPMC K4M no nā mea hoʻopili papa a me nā noi meaʻai.
Hiki i ka wai:
Hiki ke hoʻoheheʻe ʻia ka HPMC i ka wai a lilo ia i mea like me ka gel ke hoʻoheheʻe ʻia, akā hiki i ka mahana a me ka pH ke hoʻololi i kona solubility. No ka laʻana, i loko o ka wai anuanu, hiki ke hoʻoheheʻe ʻia, akā hiki ke hoʻemi ʻia kona solubility i ka wai wela, ʻoi aku ka nui ma nā ʻano kiʻekiʻe.
Hiki ke hana kiʻiʻoniʻoni:
ʻO kekahi o nā hiʻohiʻona nui o Hydroxypropyl Methylcellulose kona hiki ke hana i kahi kiʻiʻoniʻoni maʻalahi. He mea kūpono kēia waiwai no ka hoʻohana ʻana i nā ʻili papa, kahi e hāʻawi ai i kahi ʻili paheʻe, hoʻokuʻu ʻia. Maikaʻi nō hoʻi i ka ʻoihana meaʻai e hoʻomaikaʻi i ke ʻano a me ke ola o ka papa.
Gelation:
Ma kekahi mau ʻano a me nā mahana, hiki i ka HPMC ke hana i nā gels. He mea pono kēia waiwai i nā ʻano hana lāʻau lapaʻau, kahi e hoʻohana ʻia ai e hana i nā ʻōnaehana hoʻokuʻu hoʻomalu.
Nā noi o Hydroxypropyl Methylcellulose
ʻoihana lāʻau lapaʻau:
Hoʻohana ʻia ʻo HPMC ma ke ʻano he mea hoʻopaʻa i loko o nā ʻano papa papa, ʻoi aku hoʻi i nā ʻōnaehana hoʻokuʻu lōʻihi a hoʻokuʻu ʻia. Hoʻohana pū ia ma ke ʻano he mea hoʻopili no nā papa a me nā capsules e kāohi i ka hoʻokuʻu ʻana o ka mea hana. ʻO kona hiki ke hana i nā kiʻiʻoniʻoni paʻa a me nā gels kūpono no nā ʻōnaehana lawe lāʻau.
ʻOihana Meaʻai
I ka ʻoihana meaʻai, hoʻohana ʻia ʻo HPMC ma ke ʻano he mea mānoanoa, emulsifier, a me ka stabilizer i nā ʻano huahana like ʻole, me nā meaʻai, nā lole, a me nā mea i kālua ʻia. Kōkua ia i ka hoʻomaikaʻi ʻana i ke ʻano a hoʻolōʻihi i ke ola o ka mālama ʻana ma o ka hōʻemi ʻana i ka nalowale o ka makū.
Nā mea hoʻonani a me ka mālama pilikino:
Hoʻohana nui ʻia ʻo HPMC i nā mea hoʻonaninani, kahi e hana ai ʻo ia he mānoanoa a me ka stabilizer i loko o ka ʻaila, lotions, shampoos, a me nā huahana mālama pilikino ʻē aʻe. ʻO kona hiki ke hana i kahi ʻano gel he mea pono loa ia i kēia mau noi.
Hana Hana:
I loko o ka ʻoihana kūkulu hale, ʻo ia hoʻi i ka hana sima a me ka plaster formulations, hoʻohana ʻia ʻo HPMC ma ke ʻano he mea mālama wai. Kōkua ia i ka hoʻomaikaʻi ʻana i ka hana a me ka hoʻonui ʻana i nā waiwai paʻa o nā mea.
Nā noi ʻē aʻe:
Hoʻohana pū ʻia ʻo HPMC i ka ʻoihana textile, ka uhi pepa, a me ka hana ʻana i nā kiʻiʻoniʻoni biodegradable.
Hydroxypropyl Methylcellulose (HPMC)he mea hoʻohui nui loa i hoʻohana ʻia ma nā ʻoihana he nui ma muli o kāna mau waiwai kūʻokoʻa e like me ka hiki ke hana kiʻiʻoniʻoni, hiki ke mānoanoa, a me ka paʻa wai. ʻOiai ʻaʻohe ona "huahelu serial" ma ke ʻano maʻamau, ʻike ʻia ia e nā mea hōʻike kemika e like me kāna helu CAS (9004-65-3) a me nā māka kikoʻī huahana (e laʻa, HPMC K100M, HPMC E4M). ʻO ka ʻokoʻa like ʻole o nā māka HPMC i loaʻa e hōʻoia i kona hoʻohana ʻana i nā kahua like ʻole, mai nā lāʻau lapaʻau i ka meaʻai, nā mea hoʻonaninani, a me ke kūkulu ʻana.
Ka manawa hoʻouna: Mar-21-2025