1. Croscarmellose sodium(CMCNa-isku-tallaabta ah): koobiyeeyaha isku-xidhan ee CMCNa
Guryaha: Budada cad ama ka baxsan. Sababtoo ah qaab-dhismeedka isku-xiran, waa mid aan lagu milmi karin biyaha; waxay si degdeg ah u bararaan biyaha ilaa 4-8 jeer mugga asalka ah. Budadu waxay leedahay dareere wanaagsan.
Codsiga: Waa kala qaybsanaanta ugu badan ee la isticmaalo. Kala daadsan oo loogu talagalay kaniiniyada afka, kaabsal, granules.
2. Carmellose calcium (CMCC-ku-xiran):
Guryaha: Caddaan, budo aan ur lahayn, hygroscopic. 1% xal pH 4.5-6. Ku dhawaad aan lagu milmi karin ethanol iyo dareeraha ether, aan lagu milmi karin biyaha, aan milmin ee hydrochloric acid, wax yar oo ku milma alkali-ka-milo. ama budo cad-cad. Sababtoo ah qaab-dhismeedka isku-xiran, waa mid aan lagu milmi karin biyaha; way bararaan markay biyaha nuugaan.
Codsiga: kiniiniga kala daadsan, binder, diluent.
3. Methylcellulose (MC):
Qaab dhismeedka: methyl ether of cellulose
Guryaha: Caddaan ama budo cad oo hurdi ah ama granules. Aan lagu milmin biyo kulul, xal cusbo leh oo buuxa, aalkolo, ether, acetone, toluene, chloroform; ku milmay glacial acetic acid ama isku dhafka alkohol iyo chloroform ee siman. Ku milmayn biyaha qabow waxay la xidhiidhaan heerka beddelka, waxayna u badan tahay milanka marka heerka beddelku yahay 2.
Codsiga: xadhkaha kiniinka, matrixka kiniinka walaxda ama diyaarinta sii-daynta joogtada ah, kareem ama jel, wakiilka hakinta iyo wakiilka dhumucda, dahaarka kiniinka, stabilizer emulsion.
4. Ethyl cellulose (EC):
Qaab dhismeedka: Ethyl ether of cellulose
Guryaha: budo cad ama jaalle-cad iyo granules. Aan ku milmin biyaha, dareeraha caloosha iyo mindhicirka, glycerol iyo propylene glycol. Waxay si fudud ugu milmi kartaa chloroform iyo toluene, waxayna samaysaa da'da cad haddii ay dhacdo ethanol.
Codsiga: Qalabka sidaha biyaha aan milmi karin, oo ku habboon sida matrixka dawooyinka xasaasiga ah ee biyaha, sidaha biyaha-aan-milmi karin, kiniiniga kiniiniga, walxaha filimka, walxaha microcapsule iyo walxaha daahan ee sii-daynta joogtada ah, iwm.
5. Hydroxyethyl Cellulose (HEC):
Qaab dhismeedka: Qayb ka mid ah ether hydroxyethyl ee cellulose.
Guryaha: budo cad oo huruud ah ama caano leh. Si buuxda ugu milmay biyo qabow, biyo kulul, asiidh daciif ah, saldhig daciif ah, aashito xoog leh, saldhig xoog leh, aan milmin karin inta badan dareerayaasha organic (ku milma dimethyl sulfoxide, dimethylformamide), ee diol polar dareerayaasha dabiiciga ah way fidi kartaa ama qayb ahaan milmi kartaa.
Codsiyada: Qalabka polymer-ka ee aan-ionic-ka ahayn ee biyaha ku milma; dhumucyada loogu talagalay diyaarinta indhaha, otology iyo isticmaalka jirka; HEC ee saliidaha indhaha qalalan, muraayadaha indhaha iyo afka qalalan; loo isticmaalo qurxinta. Sida xidhe, wakiilka filim samaynta, wakiilka dhumucdiisuna, wakiilka laalista iyo stabilizer ee daroogooyinka iyo cuntada, waxa ay koobi kartaa qayb ka daroogada, si qayb ka daroogada u ciyaari karaan door si tartiib ah-siideyn.
6. Hydroxypropyl Cellulose (HPC):
Qaab dhismeedka: Qayb ahaan polyhydroxypropyl ether of cellulose
Guryaha: HPC-ga sare ee la beddelay waa budo cad ama wax yar oo huruud ah. Ku milmay methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide iyo dimethyl formamide, nooca viscosity-ga sare waa mid aan milmi lahayn. Aan lagu milmin biyo kulul, laakiin way barari karaan. Gelation-ka kulaylka: si fudud ayaa loogu milmay biyaha ka hooseeya 38°C, jelatin laga dhigay kulaylinta, oo waxay samaysaa barar qulqulaya 40-45°C, kaas oo lagu soo kabsan karo qaboojin.
Tilmaamaha L-HPC ee muuqda: aan milmin biyaha iyo dareerayaasha organic, laakiin barar biyaha, iyo hantida bararka ayaa kordhisa kororka beddelka
Codsiga: HPC-badal sare leh waxaa loo isticmaalaa sida kiniiniga kiniiniga ah, wakiilka granulating, walxaha daahan filimka, iyo sidoo kale waxaa loo isticmaali karaa sida walxaha filimka microencapsulated, walxaha matrixka iyo walxaha kaabaya ee kiniiniga xajinta caloosha, dhumucyada iyo colloid Protective, sidoo kale sida caadiga ah loo isticmaalo balastar transdermal.
L-HPC: Inta badan waxaa loo isticmaalaa sida kiniiniga kala-baxa ama binder ee granulation-ka qoyan, sida matrix-ka kiniiniga sii-daynta joogtada ah, iwm.
7. Hypromellose (HPMC):
Qaab dhismeedka: Qayb methyl ah iyo qayb polyhydroxypropyl ether of cellulose
Guryaha: Caddaan ama budo granular ah oo cad ama ka baxsan. Waxay ku milmi kartaa biyo qabow, oo aan lagu milmi karin biyaha kulul, waxayna leedahay sifooyin kulaylka. Waxay ku milmi kartaa xalalka methanol iyo ethanol, hydrocarbons koloriin leh, acetone, iwm
Codsiga: Alaabtani waa xal aqueous ah oo yar-yar oo loo isticmaalo sida walxaha dahaarka filimka; dareeraha dareeraha dabiiciga ah ee viscosity-sare ayaa loo isticmaalaa sida kiniiniga kiniiniga ah, iyo wax soo saarka viscosity-sare ayaa loo isticmaali karaa in lagu xannibo matrix-ka sii-deynta ee daawooyinka biyaha ku milma; sida dhibcaha indhaha ee dhumucdiisuna waxay u tahay lacquer iyo ilmada macmal ah, iyo wakiilka qoynta ee muraayadaha indhaha.
8. Hypromellose Phthalate (HPMCP):
Qaab dhismeedka: HPMCP waa phthalic acid nuska ester ee HPMC.
Guryaha: beige ama jajab cad ama granules. Aan ku milmin biyaha iyo xalalka acidic, aan lagu milmi karin hexane, laakiin si fudud ugu milmi kara acetone:methanol, acetone:ethanol ama methanol: isku darka chloromethane.
Codsiga: Nooc cusub oo walax daahan ah oo leh waxqabad aad u fiican, kaas oo loo isticmaali karo daahan filim si loo qariyo urka gaarka ah ee kiniiniyada ama granules.
9. Hypromellose Acetate Succinate (HPMCAS):
Qaab dhismeedka: Isku-dhafka acetic iyo succinic esters ofHPMC
Guryaha: Caddaan ama budo cad oo hurdi ah ama granules. Ku milma sodium hydroxide iyo sodium carbonate sodium, si fudud u milmi acetone, methanol ama ethanol: biyo, dichloromethane: ethanol isku dar ah, aan milmin biyaha, ethanol iyo ether.
Codsiga: Sida maaddada dahaarka kiniiniga ah, walxaha daahan sii daynta joogtada ah iyo walxaha dahaarka filimka.
10. Agar:
Qaab dhismeedka: Agar waa isku dar ah ugu yaraan laba polysaccharides, qiyaastii 60-80% agarose dhexdhexaad ah iyo 20-40% agarose. Agarose wuxuu ka kooban yahay agarobiose unugyo soo noqnoqda kuwaaso D-galactopyranosose iyo L-galactopyranosose ay si kala duwan ugu xidhan yihiin 1-3 iyo 1-4.
Guryaha: Agar waa mid hufan, dhululubo huruud ah oo khafiif ah, faliiq dhuuban ama qolof qolofaysan ama walxo budada leh. Aan ku milmin biyo qabow, ku milmay biyo karkaraya. Ku barara 20 jeer biyo qabow.
Codsiga: Sida wakiilka xidha, saldhiga boomaatada, saldhiga suppository, emulsifier, stabilizer, wakiilka ganaaxa, sidoo kale sida poultice, kaabsal, sharoobada, jelly iyo emulsion.
Waqtiga boostada: Abriil-26-2024