Hydroxypropyl methylcellulosewaa nooc ka mid ah cellulose aan ionic ahayn oo isku qasan. Si ka duwan ionic methyl carboxymethyl cellulose ether qasan, kuma falceliso biraha culus. Sababo la xiriira saamiga kala duwan ee methoxyl content iyo hydroxypropyl content ee hydroxypropyl methylcellulose iyo viscosities kala duwan, waxaa jira noocyo badan oo kala duwan oo leh sifooyin kala duwan, tusaale ahaan, content methoxyl sare iyo content hydroxypropyl hooseeya Waxqabadkeedu wuxuu ku dhow yahay in methyl cellulose, halka waxqabadka of content methoxyl hoose iyo hydroxypropyl content hydroxypropyl. Si kastaba ha noqotee, nooc kasta oo kala duwan, inkasta oo kaliya qadar yar oo ah kooxda hydroxypropyl ama qadar yar oo ah kooxda methoxyl ay ku jiraan, waxaa jira kala duwanaansho weyn oo ku milmay dareerayaasha organic ama heerkulka flocculation ee xalalka aqueous.
(1) Sifooyinka milmay ee hydroxypropyl methylcellulose
① milanka hydroxypropyl methylcellulose ee biyahaHydroxypropyl methylcellulosedhab ahaantii waa nooc ka mid ah methylcellulose oo lagu beddelay propylene oxide (methoxy-propylene), sidaas darteed waxay weli leedahay sifooyin la mid ah sida methyl cellulose waxay leedahay sifooyin la mid ah milanka biyaha qabow iyo biyaha kulul. Si kastaba ha ahaatee, sababtoo ah kooxda hydroxypropyl ee la bedelay, heerkulka gelation ee biyaha kulul ayaa aad uga sarreeya kan methyl cellulose. Tusaale ahaan, viscosity of hydroxypropyl methylcellulose xal aqueous leh 2% methoxy content beddelka degree DS=0.73 iyo hydroxypropyl content MS=0.46 waa 500mpa·s at 20C, iyo heerkulkeeda gel Waxay gaari kartaa meel u dhow 100 ° C, halka methyl cellulose waa qiyaastii 5 ° C. Marka laga hadlayo milanka biyaha, sidoo kale si weyn ayaa loo hagaajiyay. Tusaale ahaan, hydroxypropyl methylcellulose oo la burburiyay (qaabka granular 0.2 ~ 0.5mm at 20 ° C leh 4% viscosity xal aqueous of 2pa•s waxaa laga iibsan karaa heerkulka qolka, si fudud ayay ugu milmi kartaa biyaha iyada oo aan la qaboojin.
② Solubility of hydroxypropyl methylcellulose ee dareerayaasha organic ah milanka hydroxypropyl methylcellulose ee dareerayaasha organic sidoo kale ka fiican yahay methylcellulose. Methylcellulose wuxuu u baahan yahay inuu haysto shahaadada beddelka methoxyl ee 2.1 Alaabta kor ku xusan, laakiin ka kooban hydroxypropyl MS = 1.5 ~ 1.8 iyo methoxy DS = 0.2 ~ 1.0, hydroxypropyl methylcellulose-viscosity-sare leh oo leh wadarta bedelka ka sarreeya 1.8 ayaa lagu milmay iyo xalal biyo ah oo biyo leh milmayn. Waxa kale oo ay ku milmi kartaa hydrocarbons koloriin leh sida methylene chloride iyo chloroform, iyo dareerayaasha organic sida acetone, isopropanol iyo diacetone khamriga. Ku milmaynteeda dareerayaasha organic waxay ka fiican tahay milanka biyaha.
(2) Waxyaabaha Saamaynaya Viscosity of Hydroxypropyl Methyl Cellulose Go'aaminta viscosity caadiga ah ee hydroxypropyl methyl cellulose waxay la mid tahay kuwa kale ethers cellulose. Waxa lagu qiyaasaa 20°C iyadoo la isticmaalayo 2% xal aqueous ah sida caadiga ah. Viscosity ee alaabta la mid ah waxay kordhisaa korodhka feejignaanta. Alaabooyinka leh miisaan kala duwan oo unugyo isku mid ah, badeecada miisaankeedu weyn yahay waxay leedahay viscosity sare. Xidhiidhka ay la leedahay heerkulka ayaa la mid ah kan methyl cellulose. Marka heerkulku kor u kaco, viscosity-gu wuxuu bilaabmaa inuu hoos u dhaco, laakiin marka uu gaaro heerkul gaar ah, mawjadaha ayaa si lama filaan ah kor ugu kacaya oo dhalaalid. Heerkulka jel ee alaabooyinka viscosity-yar ayaa sarreeya. waa sare Its dhibic jel ma aha oo kaliya la xidhiidha viscosity of ether, laakiin sidoo kale la xidhiidha saamiga ka kooban ee kooxda metoxyl iyo kooxda hydroxypropyl ee ether iyo cabbirka wadarta shahaadada beddelka. Waa in la ogaadaa in hydroxypropyl methylcellulose sidoo kale waa pseudoplastic, iyo xalkeedu waa ku xasiloon yahay heerkulka qolka iyada oo aan wax hoos u dhigista viscosity marka laga reebo suurtagalnimada hoos u dhaca enzymatic.
(3) Dulqaadka milixda ee hydroxypropyl methylcellulose Tan iyo markii hydroxypropyl methylcellulose uu yahay ether aan-ionic ahayn, laguma ionized in warbaahinta biyaha, si ka duwan ethers cellulose kale ionic, sida carboxymethyl Base cellulose, in xal si ay ula falgalaan ions biraha culus iyo roobab. Cusbada guud sida chloride, bromide, fosfate, nitrate, iwm. ma soo da'ayaan marka lagu daro xalkeeda aqueous. Si kastaba ha ahaatee, ku darida milixdu waxay xoogaa saameyn ah ku leedahay heerkulka qulqulka ee xalkeeda aqueous. Marka xoogga milixdu kordho, heerkulka jelku wuu yaraadaa. Marka fiirsashada milixdu ay ka hooseyso barta qulqulka, mawjadaha xalka ayaa u muuqda inuu kordho. Sidaa darteed, qadar gaar ah oo milix ah ayaa lagu daraa, codsiga, waxay ku gaari kartaa saameyn dhumuc dhaqaale ahaan. Sidaa darteed, codsiyada qaarkood, way fiicantahay in la isticmaalo isku dhafka ether cellulose iyo milix marka loo eego xoojinta sare ee xalalka etherka si loo gaaro saameynta dhumucda.
(4) Hydroxypropyl methylcellulose acid iyo caabbinta alkali Hydroxypropyl methylcellulose guud ahaan waa mid degan asiidhyada iyo alkaliska, mana saamayso inta u dhaxaysa pH 2 ~ 12. Waxay u adkeysan kartaa xaddi asiidh iftiin ah, Sida formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, iwm. Alkalis sida soodhaha caustic, potash caustic iyo biyaha lime wax saameyn ah kuma laha, laakiin waxay kordhin karaan viscosity ee xalka, ka dibna si tartiib ah u yareynaya.
(5) Maqnaanshaha hydroxypropyl methylcellulose Hydroxypropyl methylcellulose xalka waxaa lagu qasi karaa xeryahooda polymer-ka biyaha-milmi kara si ay u noqdaan xal labis ah oo hufan oo leh viscosity sare. Xeryahooda polymer waxaa ka mid ah polyetylen glycol, polyvinyl acetate, polysilicon, polymethylvinyl siloxane, hydroxyethyl cellulose, iyo methyl cellulose. Iskudhisyada molecular sare ee dabiiciga ah sida cirridka carabiga, xanjada digirta ayaxa, xanjada karaya, iwm sidoo kale waxay leeyihiin waafaqid wanaagsan xalkeeda. Hydroxypropyl methylcellulose sidoo kale waxaa lagu qasi karaa mannitol ester ama sorbitol ester of stearic acid ama palmitic acid, sidoo kale waxaa lagu qasi karaa glycerin, sorbitol iyo mannitol, xeryahoodana waxaa loo isticmaali karaa sida hydroxypropyl methylcellulose Plasticizer for cellulose.
(6) Biyaha aan milmi karinethers celluloseee hydroxypropyl methylcellulose waxay samayn kartaa isku-tallaabta dusha sare leh aldehydes, si ay ether-yada biyaha-milmi leh ay ku soo daadato xalka oo ay noqdaan kuwo aan milmayn biyaha. Aldehydes-ka sameeya hydroxypropyl methylcellulose aan la milmi karin waxaa ka mid ah formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, iwm. Marka la isticmaalayo formaldehyde, fiiro gaar ah waa in la bixiyaa qiimaha pH ee xalka, oo ka mid ah glioxal falcelin degdeg ah, sidaas darteed glioxal waxaa caadi ahaan loo isticmaalaa wax soo saarka warshadaha sida crosslinking. Qiyaasta wakiilka noocan oo kale ah ee isku dhafka ah ee xalku waa 0.2% ~ 10% miisaanka ether, doorbidaya 7% ~ 10%, tusaale ahaan, 3.3% ~ 6% glioxal ayaa ah kan ugu habboon. Guud ahaan, heerkulka daawaynta waa 0 ~ 30 ℃, iyo waqti waa 1 ~ 120min. Falcelinta isku xidhka ayaa loo baahan yahay in lagu sameeyo xaalado aashito ah. Guud ahaan, pH ee xalka waxaa lagu hagaajiyaa ilaa 2 ~ 6 iyadoo lagu darayo aashitada xoogga leh ee aan organic ahayn ama karboksylic acid organic ee xalka, doorbidaya inta u dhaxaysa 4 ~ 6, ka dibna aldehydes ayaa lagu daraa si loo fuliyo falcelinta isdhaafsiga. Aashitada la isticmaalay ayaa leh hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy-acetic acid, succinic acid ama citric acid iwm. Aashitada iyo aldehyde ayaa sidoo kale lagu dari karaa isku mar si loogu oggolaado xalka inuu maro fal-celin isku-xiran oo dhexda u ah qiyaasta pH ee la doonayo. Dareen-celintan waxaa badanaa loo isticmaalaa habka daaweynta ugu dambeysa ee habka diyaarinta ethers cellulose. Ka dib markii ether-ka cellulose uu yahay mid aan la milmi karin, way ku habboon tahay in la isticmaalo.
20 ~ 25 ℃ biyaha lagu dhaqo iyo sifaynta. Marka badeecada la isticmaalo, walxaha alkaline ayaa lagu dari karaa xalka badeecada si loo hagaajiyo pH ee xalka si ay u noqoto alkaline, badeecaduna waxay ku milmi doontaa xalka si dhakhso ah. Habkani wuxuu sidoo kale lagu dabaqi karaa daaweynta filimka ka dib marka xalalka etherka cellulose laga sameeyo filim si looga dhigo filim aan la milmin.
(7) Iska caabbinta enzyme ee hydroxypropyl methylcellulose waa aragti ahaan derivatives cellulose, sida koox kasta oo anhydroglucose, haddii ay jirto koox si adag u xidhxidhan beddelka ah, ma fududa in lagu qaadsiiyo microorganisms, laakiin dhab ahaantii alaabta la dhammeeyey Marka qiimaha beddelka ka badan 1, waxa ay sidoo kale la hoos u dhigi doonaa by heerka silsilad kasta oo ka mid ah unugyada labbiska. ku filan, iyo microorganisms waxay baabi'in karaan kooxda anhydroglucose aan la bedelin si ay u sameeyaan sonkor, sida nafaqooyinka microorganisms si ay u nuugaan. Sidaa darteed, haddii heerka beddelka etherification ee cellulose uu kordho, iska caabinta enzymatic nabaad guurka etherka cellulose ayaa sidoo kale kordhin doona. Sida laga soo xigtay warbixinnada, xaaladaha la xakameeyey, natiijooyinka hydrolysis ee enzymes-ka la sameeyay, haraaga haraaga ee hydroxypropyl methylcellulose (DS=1.9) waa 13.2%, methylcellulose (DS=1.83) waa 7.3%, methylcellulose (DS=1.66) waa 3.8%, iyo hydroxy . Waxaa la arki karaa in hydroxypropyl methylcellulose uu leeyahay awood xoog leh oo anti-enzyme ah. Sidaa darteed, iska caabbinta enzyme aad u fiican ee hydroxypropyl methylcellulose, oo ay weheliso kala-baxsanaanteeda wanaagsan, dhumucdeeda iyo sameynta filimada, ayaa loo isticmaalaa daaha-biyoodka-emulsion-ka, iwm, iyo guud ahaan uma baahna in lagu daro waxyaabaha ilaaliya. Si kastaba ha noqotee, kaydinta muddada dheer ee xalka ama wasakheynta suurtagalka ah ee ka imanaysa dibadda, ilaalinta ayaa lagu dari karaa taxadar ahaan, doorashadana waxaa lagu go'aamin karaa iyadoo loo eegayo shuruudaha ugu dambeeya ee xalka. Phenylmercuric acetate iyo manganese fluorosilicate waa ilaalin wax ku ool ah, laakiin dhammaantood waxay leeyihiin sunta, dareenka waa in la bixiyaa hawlgalka. Guud ahaan, 1 ~ 5mg of phenylmercury acetate ayaa lagu dari karaa xalka halkii litir ee qiyaasta.
(8) Waxqabadkahydroxypropyl methylcellulosefilimka Hydroxypropyl methylcellulose wuxuu leeyahay sifooyin filim-samayn heersare ah. Xalka aqueous ama dareeraha dareeraha organic waxa lagu dahaadhay saxan quraarad ah, oo waxay noqotaa mid aan midab lahayn oo daahfuran qalajinta ka dib. Iyo filim adag. Waxay leedahay iska caabin qoyaan oo wanaagsan waxayna ku sii adkaysataa heerkulka sare. Haddii balaastikada hygroscopic lagu daro, dhererkeeda iyo dabacsanaanteeda ayaa la wanaajin karaa. Marka la eego hagaajinta dabacsanaanta, balaastikada sida glycerin iyo sorbitol ayaa ah kuwa ugu habboon. Guud ahaan, xoojinta xalku waa 2% ~ 3%, iyo qadarka balaastikada waa 10% ~ 20% eter cellulose. Haddii waxa ku jira balaastiiste aad u badan tahay, fuuqbaxa kolloidal waxay ku dhici doontaa qoyaan badan. Xoogga jilicsan ee filimka lagu daray balaastiigga ayaa aad uga weyn kan aan lahayn balaastiig, waxayna kordhisaa korodhka qadarka lagu daray. Sida hygroscopicity ee filimka, waxay sidoo kale kordhisaa kordhinta qadarka balaastikada.
Waqtiga boostada: Abriil-25-2024