Waa maxay pH ay ku milmayso HPMC

Hydroxypropyl methylcellulose (HPMC)waa polymer caadi ahaan loo isticmaalo dawooyinka, waxyaalaha la isku qurxiyo, iyo alaabta cuntada. Solubleedkeedu wuxuu ku xiran yahay arrimo kala duwan, oo ay ku jiraan pH. Guud ahaan, HPMC waxay ku milmi kartaa xaaladaha acidic iyo alkaline labadaba, laakiin milmaheedu way kala duwanaan kartaa iyadoo ku saleysan heerka beddelka (DS) iyo miisaanka kelli (MW) ee polymerka.

Xaaladaha aashitada, HPMC waxay caadi ahaan muujisaa milmayn wanaagsan sababtoo ah protonation-ka kooxaheeda hydroxyl, taas oo kor u qaadaysa fuuq-baxa iyo kala firdhiskeeda. Solubility ee HPMC waxay u egtahay inay korodho marka pH ay hoos u dhacdo pKa, taas oo ku dhow 3.5-4.5 iyadoo ku xiran heerka beddelka.

Taa beddelkeeda, xaaladaha alkaline, HPMC waxay sidoo kale noqon kartaa mid milmay, gaar ahaan qiimaha pH sare. Marka pH alkaline, deprotonation ee kooxaha hydroxyl dhacdaa, taasoo keentay in la kordhiyo milanka iyada oo isku xidhka hydrogen iyo molecules biyaha.

Si kastaba ha ahaatee, waxaa muhiim ah in la ogaado in pH saxda ah ee uu HPMC ku noqonayo mid milmay ay ku kala duwanaan karto iyadoo lagu saleynayo darajada gaarka ah ee HPMC, heerka beddelka, iyo culeyskeeda kelli. Caadi ahaan, darajooyinka HPMC ee leh darajo sare oo beddelaad ah iyo miisaanyo unugyo hoose ah waxay muujinayaan milmayn wanaagsan oo leh qiimaha pH hoose.

Qaababka dawooyinka,HPMCwaxaa inta badan loo isticmaalaa sidii filim hore, dhumuc, ama xasiliye. Sifooyinkeeda milma ayaa muhiim u ah xakamaynta muuqaalada siidaynta daroogada, viscosity of formula, iyo xasiloonida emulsions ama ka joojinta.

halka HPMC ay guud ahaan ku milmi karto pH balaadhan, habdhaqankeeda milmi kara waxa lagu hagaajin karaa iyadoo la hagaajinayo pH ee xalka iyo xulashada darajada ku haboon ee HPMC iyadoo lagu salaynayo codsiga la rabo.