Nuwuhe mutungo wa viscosity wa hydroxypropyl methylcellulose igisubizo cyamazi?

Hydroxypropyl methylcellulose (HPMC)ni amazi ya elegitoronike ya polymer akoreshwa cyane muri farumasi, ubwubatsi, ibiryo, kwisiga no mubindi bice. Umutungo wacyo wijimye ni ikintu cyingenzi cyo gupima imyitwarire ya rheologiya ahantu hatandukanye. Gusobanukirwa imitungo ya viscosity ya HPMC igisubizo cyamazi bidufasha kumva neza imyitwarire n'imikorere mubikorwa bitandukanye.

1. Imiterere yimiti nimiterere ya HPMC

HPMC iboneka muguhindura imiti ya selile karemano, ahanini ikorwa na hydroxypropylation na methylation ya molekile ya selile. Mu miterere yimiti ya HPMC, kwinjiza methyl (-OCH₃) na hydroxypropyl (-OCH₂CHOHCH₃) bituma itangira gukama amazi kandi ifite ubushobozi bwo guhindura neza ububobere. Imikorere ya viscosity yumuti wacyo wamazi mubushyuhe butandukanye hamwe nubushyuhe bigira ingaruka kubintu byinshi nkuburemere bwa molekile, urugero rwo gusimbuza, kwibanda kumuti, nibindi.

2. Isano iri hagati yubukonje no kwibanda

Ubukonje bwa AnxinCel®HPMC igisubizo cyamazi gikunze kwiyongera hamwe no kwiyongera. Ibi ni ukubera ko iyo yibanze cyane, imikoranire hagati ya molekile iratera imbere, bigatuma irwanya umuvuduko mwinshi. Nyamara, ibishishwa hamwe nubwiza bwa HPMC mumazi nabyo bigira ingaruka kuburemere bwa molekile. HPMC ifite uburemere buke bwa molekuline mubisanzwe igaragaza ububobere buke, mugihe uburemere buke bwa molekile buri hasi.

Mubitekerezo bike: Igisubizo cya HPMC cyerekana ububobere buke munsi yibitekerezo (nko munsi ya 0.5%). Muri iki gihe, imikoranire hagati ya molekile irakomeye kandi amazi ni meza. Ubusanzwe ikoreshwa mubisabwa nka coatings hamwe nibiyobyabwenge bikomeza kurekurwa.

Mubitekerezo byinshi: Mugihe cyo hejuru cyane (nka 2% cyangwa irenga), ubwiza bwumuti wamazi wa HPMC bwiyongera cyane, byerekana imitungo isa nibisubizo bya colloidal. Muri iki gihe, ibisubizo byigisubizo birashobora guhangana cyane.

3. Isano iri hagati yubukonje nubushyuhe

Ubukonje bwamazi ya HPMC yunvikana cyane kubushyuhe. Mugihe ubushyuhe bwiyongera, kugenda hagati ya molekile zamazi biriyongera, kandi imikoranire hagati ya molekile ya HPMC igacika intege, bigatuma kugabanuka kwijimye. Ibiranga bituma ikoreshwa rya HPMC mubushyuhe butandukanye ryerekana ihinduka rikomeye. Kurugero, mugihe cyubushyuhe bwo hejuru, ubukonje bwa HPMC mubusanzwe buragabanuka, ibyo bikaba ari ingenzi cyane mubikorwa bya farumasi, cyane cyane muburyo bwa dosiye irekura imiti, aho ihindagurika ryubushyuhe rishobora kugira ingaruka kumyitwarire n'ingaruka zumuti.

4. Ingaruka za pH kuri Viscosity

Ubwiza bwumuti wamazi wa HPMC burashobora kandi guterwa nigiciro cya pH cyigisubizo. Nubwo HPMC ari ibintu bitari ionic, hydrophilicity hamwe nubwiza bwayo bigira ingaruka cyane cyane kumiterere ya molekile hamwe nibidukikije. Nyamara, mugihe cya acide cyane cyangwa alkaline, imiterere ya molekuline na molekuline ya HPMC irashobora guhinduka, bityo bikagira ingaruka kumitsi. Kurugero, mubihe bya acide, solubile ya HPMC irashobora gucika intege nkeya, bigatuma ubwiyongere bwiyongera; mugihe mubihe bya alkaline, hydrolysis ya HPMC ishobora gutuma uburemere bwa molekile bugabanuka, bityo bikagabanya ubukana bwayo.

5. Uburemere bwa molekuline nubusembwa

Uburemere bwa molekuline nimwe mubintu byingenzi bigira ingaruka kumyuka yumuti wa HPMC. Uburemere buke bwa molekile bwongera kwizirika no guhuza hagati ya molekile, bikaviramo kwiyongera. Uburemere buke bwa molekuline AnxinCel®HPMC ifite imbaraga zo gukemura neza mumazi hamwe nubwiza buke. Ibisabwa bitandukanye mubisanzwe bisaba guhitamo HPMC hamwe nuburemere butandukanye bwa molekile. Kurugero, mubitambaro no gufatira hamwe, uburemere buke bwa molekile HPMC mubisanzwe byatoranijwe kugirango bifatanye neza kandi bitemba; mugihe mugutegura imiti, uburemere buke bwa molekile HPMC irashobora gukoreshwa mugucunga igipimo cyibiyobyabwenge.

6. Isano iri hagati yikigereranyo cyogosha nubwiza

Ubukonje bwamazi ya HPMC mubusanzwe burahinduka nigipimo cyogosha, byerekana imyitwarire ya pseudoplastique. Amazi ya pseudoplastique ni amazi afite ubwiza bwayo bugabanuka buhoro buhoro hamwe no kwiyongera kwimisatsi. Ibi biranga bituma HPMC ikemura kugirango igumane ubukonje bwinshi ku gipimo gito cyogosha iyo ikoreshejwe, kandi ikongerera amazi umuvuduko mwinshi. Kurugero, mu nganda zitwikiriye, igisubizo cya HPMC gikenera kwerekana ubukonje bwinshi ku gipimo cyo hasi cyogosha iyo gishyizwe mubikorwa kugirango hafatwe ingamba hamwe no kuringaniza igifuniko, mugihe mugihe cyubwubatsi, birakenewe kongera igipimo cyogosha kugirango gikorwe neza.

7. Gushyira hamwe nibiranga HPMC

Ibiranga ubwiza bwaHPMCkora ikoreshwa cyane mubice byinshi. Kurugero, muruganda rwa farumasi, HPMC ikoreshwa nkumuti uhoraho-urekura, kandi amabwiriza yacyo yo kwisiga akoreshwa mukugenzura igipimo cy’ibiyobyabwenge; mu nganda zubaka, HPMC ikoreshwa nkibyimbye kugirango itezimbere imikorere n’amazi ya minisiteri hamwe n’ibiti; mu nganda zibiribwa, HPMC irashobora gukoreshwa nkibyimbye, emulisiferi na stabilisateur kugirango uburyohe nibigaragara byibiryo.

Ibiranga viscosity biranga AnxinCel®HPMC igisubizo cyamazi nurufunguzo rwo kuyikoresha mubice bitandukanye. Gusobanukirwa isano bifitanye nibintu nko kwibanda, ubushyuhe, pH, uburemere bwa molekuline nigipimo cyogosha ningirakamaro cyane mugutezimbere imikorere yibicuruzwa no kunoza ingaruka zikoreshwa.