Hydroxypropyl Methylcellulose (HPMC)ni polymer yamashanyarazi ikunze gukoreshwa mubikorwa bya farumasi, ibiryo, amavuta yo kwisiga, nubwubatsi. Ibirungo bya HPMC bigira uruhare runini mugutunganya no gutuza. Ihindura imiterere ya rheologiya, gukomera, hamwe nubuzima bwibintu. Gusobanukirwa ibirimo ubuhehere nibyingenzi muburyo bwo kubikora, kubika, no gukoresha amaherezo.
Ibirungo bya HPMC
Ubushuhe bwa AnxinCel®HPMC muri rusange bugenwa nuburyo ibintu bigenda ndetse nicyiciro cyihariye cya polymer yakoreshejwe. Ibirungo birashobora gutandukana bitewe nibikoresho fatizo, uburyo bwo kubika, nuburyo bwo kumisha. Mubisanzwe bigaragazwa nkijanisha ryuburemere bwicyitegererezo mbere na nyuma yo gukama. Kubikorwa byinganda, ibirimo ubuhehere nibyingenzi, kuko ubuhehere bukabije bushobora gutera kwangirika, gufatana, cyangwa kugabanya imikorere ya HPMC.
Ubushuhe bwa HPMC burashobora kuva kuri 5% gushika 12%, naho urwego rusanzwe ruri hagati ya 7% na 10%. Ibirungo birashobora kugenwa no kumisha icyitegererezo ku bushyuhe bwihariye (urugero, 105 ° C) kugeza kigeze ku buremere buhoraho. Itandukaniro ryibiro mbere na nyuma yo gukama byerekana ibirimo ubuhehere.
Ibintu bigira ingaruka kubirimo muri HPMC
Impamvu nyinshi zirashobora kugira ingaruka kubutaka bwa HPMC:
Ubushuhe n'ububiko:
Ubushuhe bwinshi cyangwa ububiko budakwiye burashobora kongera ubuhehere bwa HPMC.
HPMC ni hygroscopique, bivuze ko ikunda gukuramo ubuhehere buturuka mu kirere gikikije.
Gupakira no gufunga ibicuruzwa birashobora kugabanya kwinjiza neza.
Uburyo bwo gutunganya:
Ubushyuhe bwumwanya nigihe mugihe cyo gukora birashobora kugira ingaruka kumyunyu wanyuma.
Kuma vuba birashobora kuvamo ubushuhe busigaye, mugihe gukama buhoro bishobora gutera ubuhehere bwinshi.
Icyiciro cya HPMC:
Ibyiciro bitandukanye bya HPMC (urugero, ubukonje buke, ubukonje buciriritse, cyangwa ubukonje bwinshi) birashobora kugira ibintu bitandukanije gato bitewe nubusumbane bwimiterere ya molekile no kuyitunganya.
Ibisobanuro by'abatanga isoko:
Abatanga isoko barashobora gutanga HPMC hamwe nubushuhe bwihariye bujyanye nuburinganire bwinganda.
Ubushuhe busanzwe bwa HPMC na Grade
Ibirungo bya HPMC biratandukana bitewe nurwego no gukoresha. Hano hari imbonerahamwe yerekana ubushuhe busanzwe bwurwego rwibyiciro bitandukanye bya HPMC.
| Icyiciro cya HPMC | Viscosity (cP) | Ibirungo (%) | Porogaramu |
| HPMC | 5 - 50 | 7 - 10 | Imiti (ibinini, capsules), kwisiga |
| Hagati ya Viscosity HPMC | 100 - 400 | 8 - 10 | Imiti (kurekurwa kugenzurwa), ibiryo, ibifata |
| HPMC | 500 - 2000 | 8 - 12 | Ubwubatsi (bushingiye kuri sima), ibiryo (umukozi wo kubyimba) |
| Imiti ya HPMC | 100 - 4000 | 7 - 9 | Ibinini, capsule yatwikiriye, gel |
| HPMC | 50 - 500 | 7 - 10 | Kwiyongera kwibiryo, emulisation, gutwikira |
| Icyiciro cyubwubatsi HPMC | 400 - 10000 | 8 - 12 | Mortar, ibifatika, plaster, imvange yumye |
Kwipimisha no Kumenya Ibirimo Ubushuhe
Hariho uburyo bwinshi busanzwe bwo kumenya ubuhehere bwa HPMC. Uburyo bubiri bukunze kugaragara ni:
Uburyo bwa Gravimetric (Gutakaza Kuma, LOD):
Ubu ni bwo buryo bukoreshwa cyane mu kumenya ibirimo ubuhehere. Uburemere buzwi bwa HPMC bushyirwa mu ziko ryumye ryashyizwe kuri 105 ° C. Nyuma yigihe cyagenwe (mubisanzwe amasaha 2-4), icyitegererezo cyongeye gupimwa. Itandukaniro ryibiro ritanga ibirimo ubuhehere, bigaragazwa nkijanisha ryuburemere bwintangarugero.
Karl Fischer Titration:
Ubu buryo burasobanutse neza kuruta LOD kandi burimo imiti igereranya ibirimo amazi. Ubu buryo busanzwe bukoreshwa mugihe hagomba kugenwa neza neza ubushuhe.
Ingaruka Ibirimo Ubushuhe kubintu bya HPMC
Ibirungo bya AnxinCel®HPMC bigira ingaruka kumikorere yabyo bitandukanye:
Viscosity:Ibirungo birashobora kugira ingaruka ku bwiza bwibisubizo bya HPMC. Ibirungo byinshi birashobora kongera ubukonje muburyo bumwe, mugihe ubuhehere buke bushobora gutuma habaho ubukonje buke.
Gukemura:Ubushuhe bukabije burashobora gutuma habaho agglomeration cyangwa kugabanuka kwa HPMC mumazi, bigatuma bidakorwa neza mubikorwa bimwe na bimwe, nko kugenzura imiti irekurwa mu nganda zimiti.
Igihagararo:HPMC muri rusange ihagaze neza mugihe cyumye, ariko ubuhehere bwinshi burashobora gutuma mikorobe ikura cyangwa kwangirika kwimiti. Kubera iyo mpamvu, HPMC isanzwe ibikwa mubikoresho bifunze ahantu hacye cyane.
Ibirungo hamwe nububiko bwa HPMC
Bitewe na hygroscopique ya HPMC, gupakira neza ni ngombwa kugirango wirinde kwinjiza amazi mu kirere. HPMC isanzwe ipakirwa mumifuka itagira ubushyuhe cyangwa ibikoresho bikozwe mubikoresho nka polyethylene cyangwa laminates nyinshi kugirango birinde ubushuhe. Gupakira byemeza ko ubuhehere buguma murwego rwifuzwa mugihe cyo kubika no gutwara.
Kugenzura Ibirimo Ubushuhe mubikorwa
Mugihe cyo gukora HPMC, ni ngombwa kugenzura no kugenzura ibirimo ubuhehere kugirango ubuziranenge bwibicuruzwa. Ibi birashobora kugerwaho binyuze:
Uburyo bwo Kuma:HPMC irashobora gukama ukoresheje umwuka ushushe, kumisha vacuum, cyangwa ibyuma byuma. Ubushuhe hamwe nigihe cyo kumisha bigomba kuba byiza kugirango wirinde gukama (ibirimo ubuhehere bwinshi) no gukama cyane (bishobora gutera kwangirika kwubushyuhe).
Kugenzura ibidukikije:Kubungabunga ibidukikije bigenzurwa nubushyuhe buke mukarere kibyara umusaruro ni ngombwa. Ibi birashobora kubamo imyanda, guhumeka, no gukoresha ibyuma bifata ibyuma bikurikirana kugirango ikirere gikurikirane ikirere mugihe cyo gutunganya.
Ubushuhe bwa HPMCmubisanzwe bigwa murwego rwa 7% kugeza 10%, nubwo bishobora gutandukana bitewe nurwego, porogaramu, nuburyo bwo kubika. Ibirimwo nibintu byingenzi bigira ingaruka kumiterere ya rheologiya, gukomera, no gutuza kwa AnxinCel®HPMC. Ababikora nababashinzwe gukora bagomba kugenzura neza no kugenzura ibirimo ubuhehere kugirango barebe imikorere myiza mubikorwa byabo byihariye.
Igihe cyo kohereza: Mutarama-20-2025