Hydroxypropyl methylcellulose (HPMC)ni selile ya ionic selile ikoreshwa cyane mubikoresho byubaka, ubuvuzi, ibiryo, amavuta yo kwisiga nizindi nganda. Ibipimo byingenzi bya tekiniki bya HPMC birimo ibintu bya fiziki na chimique, solubile, viscosity, urwego rwo gusimbuza, nibindi.
1. Kugaragara n'ibiranga shingiro
Ubusanzwe HPMC ni ifu yera cyangwa idafite umweru, impumuro nziza, uburyohe, ntabwo ari uburozi, hamwe no gukemura neza kwamazi. Irashobora gukwirakwira vuba no gushonga mumazi akonje kugirango ibe igisubizo kibonerana cyangwa gike cyane, kandi gifite imbaraga nke mumashanyarazi.
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Viscosity ni kimwe mu bipimo byingenzi bya tekinike ya HPMC, igena imikorere ya AnxinCel®HPMC mubikorwa bitandukanye. Ubukonje bwa HPMC bupimwa muri rusange nk'umuti wa 2% w'amazi kuri 20 ° C, kandi ubusanzwe bwijimye buri hagati ya 5 mPa · s na 200.000 mPa · s. Iyo hejuru yubusembwa, niko imbaraga zo kubyibuha zikomeye nigisubizo cyiza. Iyo ikoreshejwe mu nganda nk'ubwubatsi n'ubuvuzi, icyiciro gikwiye cyo guhitamo kigomba gutoranywa ukurikije ibikenewe byihariye.
3. Methoxy na Hydroxypropoxy Ibirimo
Imiterere yimiti ya HPMC igenwa ahanini nuburyo bukoreshwa (–OCH₃) na hydroxypropoxy (–OCH₂CHOHCH₃) impamyabumenyi. HPMC ifite impamyabumenyi zitandukanye zo gusimbuza zigaragaza imbaraga zitandukanye, ibikorwa byo hejuru hamwe nubushyuhe bwa gelation.
Methoxy Ibirimo: Mubisanzwe hagati ya 19.0% na 30.0%.
Hydroxypropoxy Ibirimo: Mubisanzwe hagati ya 4.0% na 12.0%.
4. Ibirimwo
Ubushuhe bwa HPMC bugenzurwa muri ≤ 5.0%. Ubushuhe buri hejuru buzagira ingaruka kumutekano no gukoresha ibicuruzwa.
5. Ibirimo ivu
Ivu nigisigara nyuma ya HPMC itwitswe, cyane cyane mumyunyu ngugu ikoreshwa mugikorwa cyo kubyara. Ibirimo ivu mubisanzwe bigenzurwa kuri .01.0%. Ivu ryinshi cyane rishobora kugira ingaruka kumucyo no kwera kwa HPMC.
6. Gukemura no gukorera mu mucyo
HPMC ifite amazi meza kandi irashobora gushonga vuba mumazi akonje kugirango ikore igisubizo kimwe. Gukorera mu mucyo biterwa nubuziranenge bwa HPMC nuburyo bwo gusesa. Igisubizo cyiza-cyiza cya HPMC mubusanzwe kibonerana cyangwa amata make.
7. Ubushyuhe bwa Gel
HPMC igisubizo cyamazi kizakora gel mubushyuhe runaka. Ubushyuhe bwa geli busanzwe buri hagati ya 50 na 90 ° C, bitewe nibiri muri mikorobe na hydroxypropoxy. HPMC ifite vitamine nkeya ifite ubushyuhe bwa gel, mugihe HPMC ifite hydroxypropoxy nyinshi ifite ubushyuhe buke bwa gel.
8. Agaciro pH
Agaciro pH ka AnxinCel®HPMC igisubizo cyamazi mubusanzwe kiri hagati ya 5.0 na 8.0, kidafite aho kibogamiye cyangwa alkaline nkeya kandi ikwiranye nibidukikije bitandukanye.
9. Ingano y'ibice
Ubwiza bwa HPMC bugaragazwa muri rusange nkijanisha rinyura kuri 80-mesh cyangwa 100-mesh. Mubisanzwe birasabwa ko ≥98% banyura muri 80-mesh ya ecran kugirango barebe ko ifite itandukaniro ryiza kandi ikemuka iyo ikoreshejwe.
10. Ibirimo ibyuma biremereye
Ibyuma biremereye (nka gurş na arsenic) bya HPMC bigomba kubahiriza ibipimo nganda bijyanye. Mubisanzwe, ibiyobora ni ≤10 ppm naho ibirimo arsenic ni ≤3 ppm. Cyane cyane mu biribwa no mu rwego rwa farumasi HPMC, ibisabwa kubintu birimo ibyuma biremereye birakomeye.
11. Ibipimo bya mikorobe
Ku rwego rwa farumasi n’ibiribwa AnxinCel®HPMC, hagomba kugenzurwa kwanduza mikorobe, harimo umubare w’abakoloni bose, ibumba, umusemburo, E. coli, nibindi, bisaba:
Umubare wabakoloni bose ≤1000 CFU / g
Umubare wuzuye hamwe numusemburo ≤100 CFU / g
E. coli, Salmonella, nibindi ntibigomba kumenyekana
12. Ahantu h'ingenzi hasabwa
HPMC ikoreshwa cyane mu nganda nyinshi bitewe n'ubunini bwayo, kubika amazi, gukora firime, gusiga amavuta, emulisitiya nibindi bintu:
Inganda zubaka: Nkumukozi wibyimbye namazi yo kubika amazi mumasima ya sima, ifu yimbuto, ifata ya tile, hamwe nudukingirizo twamazi adafite amazi kugirango tunoze imikorere yubwubatsi.
Inganda zimiti: Zikoreshwa nkibikoresho bifata, bikomeza-kurekura, hamwe na capsule shell ibikoresho fatizo byibinini byibiyobyabwenge.
Inganda zibiribwa: zikoreshwa nka emulisiferi, stabilisateur, kubyimbye, ikoreshwa muri jelly, ibinyobwa, ibicuruzwa bitetse, nibindi.
Inganda zikora imiti ya buri munsi: zikoreshwa nka stabilisateur ya emulifier na emulisiferi mubicuruzwa byita kuruhu, ibikoresho byoza, na shampo.
Ibipimo bya tekinike yaHPMCshyiramo viscosity, urwego rwo gusimbuza (hydrolyzed group group), ubushuhe, ibirimo ivu, agaciro ka pH, ubushyuhe bwa gel, ubwiza, ibyuma biremereye, nibindi. Ibipimo byerekana imikorere yabyo mubice bitandukanye. Mugihe uhisemo HPMC, abakoresha bagomba kumenya ibisobanuro bikwiranye nibisabwa byihariye kugirango babone ingaruka nziza zo gukoresha.
Igihe cyo kohereza: Gashyantare-11-2025