Gusobanukirwa na Hydroxypropyl Methylcellulose (HPMC) mumashanyarazi atandukanye ningirakamaro mubikorwa byinshi, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi. HPMC ni semisintetike, inert, polymer ya viscoelastic ikomoka kuri selile. Imyitwarire yayo yo kwikemurira mumashanyarazi atandukanye igira uruhare runini mubikorwa byayo.
Intangiriro kuri HPMC:
Hydroxypropyl Methylcellulose (HPMC) ni inkomoko ya selile, yahinduwe no kuvura selile hamwe na oxyde ya propylene na methyl chloride. Urwego rwo gusimbuza hydroxypropyl hamwe na matsinda ya mikorerexy itegeka imiterere ya fiziki ya chimique, harimo no gukemuka. HPMC izwi cyane mu gukora firime, kubyimba, no kwigana, bigatuma iba ibintu byinshi mu nganda zitandukanye.
Ibintu bigira ingaruka kubikemura:
Impamyabumenyi yo gusimbuza (DS): DS ya HPMC, igereranya umubare mpuzandengo w'amatsinda ya hydroxyl yasimbuwe kuri anhydroglucose, bigira uruhare runini mu gukemura. DS yo hejuru yongerera imbaraga amazi kandi igabanya ubukana bwa organic solvent.
Uburemere bwa molekuline (MW): Uburemere buke bwa molekile ya HPMC polymers ikunda kugabanya ubukana kubera kwiyongera kwimikoranire.
Ubushyuhe: Mubisanzwe, ubushyuhe bwo hejuru bwongera imbaraga za HPMC mumashanyarazi, cyane cyane muri sisitemu ishingiye kumazi.
Imikoreshereze ya Solvent-Polymer: Imiterere yumuti nka polarite, ubushobozi bwo guhuza hydrogène, hamwe na dielectric ihoraho bigira ingaruka kuri HPMC. Umuyoboro wa polar nkamazi, alcool, na ketone bikunda gushonga HPMC neza kubera guhuza hydrogene.
Kwishyira hamwe: Rimwe na rimwe, kwiyongera kwa polymer birashobora gutuma umuntu agabanuka bitewe nubwinshi bwijimye hamwe nogukora gel.
Gukemura muburyo butandukanye:
Amazi: HPMC yerekana imbaraga zidasanzwe mumazi kubera imiterere ya hydrophilique hamwe nubushobozi bwa hydrogène. Ububasha bwiyongera hamwe na DS yo hejuru hamwe nuburemere buke bwa molekile.
Inzoga (Ethanol, Isopropanol): HPMC yerekana gukemura neza muri alcool kubera ko hari amatsinda ya hydroxyl yorohereza imikoranire ya hydrogen.
Acetone: Acetone ni polar aprotic solvent ibasha gushonga HPMC neza kubera polarite hamwe nubushobozi bwa hydrogène.
Chlorine Solvents (Chloroform, Dichloromethane): Iyi mashanyarazi ntabwo ikunzwe cyane kubera impungenge z’ibidukikije n’umutekano. Ariko, barashobora gusesa HPMC neza kubera polarite yabo.
Aromatic Solvents (Toluene, Xylene): HPMC ifite ubushobozi buke bwo gushonga mumashanyarazi ya aromatiya kubera imiterere yabyo idafite inkingi, biganisha ku mikoranire idakomeye.
Acide Organic Acide (Acide Acide): Acide organique irashobora gushonga HPMC binyuze mumikoranire ya hydrogène, ariko imiterere ya acide irashobora kugira ingaruka kumitekerereze ya polymer.
Amazi ya Ionic: Amazi amwe n'amwe ya ionic yakozweho ubushakashatsi kubushobozi bwabo bwo gushonga HPMC neza, atanga ubundi buryo bwo gukemura ibibazo gakondo.
Porogaramu:
Imiti ya farumasi: HPMC ikoreshwa cyane mubikorwa bya farumasi nka binder, firime yahoze, kandi ikomeza kurekura bitewe na biocompatibilité, idafite uburozi, hamwe nuburyo bugenzurwa.
Inganda zikora ibiryo: Mubisabwa mubiribwa, HPMC ikora nk'ibyimbye, stabilisateur, na emulisiferi mubicuruzwa nka sosi, imyambarire, hamwe na cream.
Ubwubatsi: HPMC ikoreshwa mubikoresho byubwubatsi nka sima, minisiteri, nibicuruzwa bishingiye kuri gypsumu kugirango bitezimbere imikorere, kubika amazi, no gufatira hamwe.
Amavuta yo kwisiga: HPMC iboneka mubicuruzwa bitandukanye byo kwisiga nka cream, amavuta yo kwisiga, na shampo nkumubyimba hamwe na firime yahoze, itanga ubwuzu no gutuza.
Gusobanukirwa nubushake bwa HPMC mumashanyarazi atandukanye nibyingenzi mugutezimbere imikorere yayo mubikorwa bitandukanye. Ibintu nkurwego rwo gusimbuza, uburemere bwa molekile, ubushyuhe, hamwe na solvent-polymer bigira ingaruka kumyitwarire yacyo. HPMC yerekana imbaraga zidasanzwe mu mazi no mumashanyarazi, bigatuma ikora cyane mubuhanga mu bya farumasi, ibiryo, ubwubatsi, no kwisiga. Ubundi bushakashatsi kuri sisitemu yo gukemura ibibazo hamwe nubuhanga bwo gutunganya birashobora kwagura ibikorwa bya HPMC mu nganda zinyuranye mugihe gikemura ibibazo by’ibidukikije n’umutekano bijyana n’umuti gakondo.
Igihe cyo kohereza: Gicurasi-10-2024