Urwego rwa Hydroxypropyl Methylcellulose Gel Ubushyuhe

Hydroxypropyl Methylcellulose (HPMC)ni polymer yamashanyarazi ikunze gukoreshwa mubikorwa bya farumasi, kwisiga no kurya. Bitewe nubwiza buhebuje bwamazi hamwe nuburyo bwo guhindura ibishishwa, HPMC ikoreshwa cyane muri geles, imiti igabanya ibiyobyabwenge, guhagarika, kubyimba no mubindi bice. Ubwoko butandukanye nibisobanuro bya HPMC bifite ubushyuhe butandukanye, cyane cyane mugihe utegura geles ya HPMC, ubushyuhe bugira uruhare runini mubishobora gukemuka, kwiyegeranya no gutuza.

Iseswa rya HPMC hamwe nubushyuhe bwa gel

Ubushyuhe bwo kugabanuka
Ubusanzwe HPMC ishonga mumazi n'amazi ashyushye, kandi ubushyuhe bwo gushonga biterwa nuburemere bwa molekile hamwe nurwego rwa methylation na hydroxypropylation. Muri rusange, ubushyuhe bwo gusesa bwa HPMC buri hagati ya 70 ° C na 90 ° C, kandi ubushyuhe bwihariye bwo guseswa bugira ingaruka kubisobanuro bya HPMC hamwe no kwibanda kumuti. Kurugero, ubukonje buke HPMC mubisanzwe bishonga mubushyuhe buke (hafi 70 ° C), mugihe HPMC ifite ubukonje bwinshi irashobora gusaba ubushyuhe bwo hejuru (hafi 90 ° C) kugirango bishonga burundu.

Ubushyuhe bwa Gel (Ubushyuhe bwa Gelation)
HPMC ifite imitungo idasanzwe ya termoreversible gel, ni ukuvuga, izakora gel mubipimo byubushyuhe runaka. Ubushyuhe bwa gel ya HPMC bwibasiwe cyane nuburemere bwa molekuline, imiterere yimiti, kwibanda kumuti nibindi byongerwaho. Muri rusange, ubushyuhe bwa gel ya HPMC mubusanzwe ni 35 ° C kugeza 60 ° C. Muri uru rwego, iminyururu ya HPMC izongera gutondekanya gukora imiterere y'urusobekerane rw'imiterere itatu, bigatuma igisubizo gihinduka kiva mumazi kijya muri geli.

Ubushyuhe bwihariye bwa gel (ni ukuvuga ubushyuhe bwa gelation) burashobora kugenwa mubigeragezo. Ubushyuhe bwa gelation ya HPMC mubusanzwe biterwa nibintu bikurikira:

Uburemere bwa molekuline: HPMC ifite uburemere buke bwa molekile irashobora gukora gel mubushyuhe buke.

Kwibanda kumuti: Iyo hejuru yibisubizo byumuti, niko ubushyuhe bwa gel bugabanuka.

Impamyabumenyi ya methylation hamwe na hydroxypropylation: HPMC ifite methylation yo mu rwego rwo hejuru ikora geli ku bushyuhe buke kuko methylation yongera imikoranire hagati ya molekile.

Ingaruka yubushyuhe
Mubikorwa bifatika, ubushyuhe bugira ingaruka zikomeye kumikorere no gutuza kwa HPMC. Ubushyuhe bwo hejuru bwongera umuvuduko wa molekile ya HPMC, bityo bikagira ingaruka ku gukomera no gukomera biranga gel. Ibinyuranye, ubushyuhe buke bushobora kugabanya hydrasi ya gel ya HPMC bigatuma imiterere ya gel idahinduka. Byongeye kandi, ihinduka ryubushyuhe rishobora nanone gutera imikoranire hagati ya molekile ya HPMC nimpinduka mubwiza bwumuti.

Imyitwarire ya HPMC kuri pH zitandukanye nimbaraga za ionic

Imyitwarire ya gelation ya HPMC ntabwo ihindurwa nubushyuhe gusa, ahubwo inagira ingaruka kuri pH hamwe nimbaraga za ionic. Kurugero, imyitwarire ya solubilité na gelation ya HPMC kubiciro bitandukanye bya pH bizaba bitandukanye. Ubushobozi bwa HPMC burashobora kugabanuka mubidukikije bya acide, mugihe imbaraga zayo zishobora kwiyongera mubidukikije bya alkaline. Mu buryo nk'ubwo, kwiyongera kwingufu za ionic (nko kongeramo umunyu) bizagira ingaruka kumikoranire hagati ya molekile ya HPMC, bityo bihindure imiterere nogukomera kwa gel.

Gukoresha gel ya HPMC nibiranga ubushyuhe bwayo

Ubushyuhe buranga gel ya HPMC ituma ikoreshwa cyane mukurekura ibiyobyabwenge, gutegura kwisiga no mubindi bice:

Kugenzura ibiyobyabwenge
Mu gutegura ibiyobyabwenge, HPMC ikoreshwa nka matrike igenzurwa, kandi imiterere yayo ya gelation ikoreshwa muguhuza igipimo cyo kurekura ibiyobyabwenge. Muguhindura ubushyuhe nubushyuhe bwa HPMC, irekurwa ryibiyobyabwenge birashobora kugenzurwa neza. Ihinduka ry'ubushyuhe bw'ibiyobyabwenge mu nzira ya gastrointestinal birashobora gutera kubyimba gel ya HPMC no kurekura buhoro buhoro ibiyobyabwenge.

Amavuta yo kwisiga hamwe nibicuruzwa byawe bwite
HPMC isanzwe ikoreshwa mu kwisiga nk'amavuta yo kwisiga, geles, imisatsi, hamwe na cream y'uruhu. Bitewe n'ubushyuhe bwacyo, HPMC irashobora guhindura imiterere nuburinganire bwibicuruzwa mubihe bitandukanye byubushyuhe. Imihindagurikire yubushyuhe muburyo bwo kwisiga igira ingaruka zikomeye kumyitwarire yimikorere ya HPMC, kubwibyo HPMC ikwiye igomba guhitamo neza mugihe cyo gutegura ibicuruzwa.

Inganda zikora ibiribwa
Mu biryo, HPMC ikoreshwa cyane nkibyimbye na emulisiferi, cyane cyane mubiribwa byiteguye kurya. Imiterere yubushyuhe bwayo ituma HPMC ihindura imiterere yumubiri mugihe cyo gushyushya cyangwa gukonjesha, bityo bikagira ingaruka kuburyohe nimiterere yibyo kurya.

Ubushyuhe bwaHPMCgeles nikintu cyingenzi mubikorwa byabo. Muguhindura ubushyuhe, kwibanda, hamwe no guhindura imiti, imiterere ya geles ya HPMC, nkibishobora gukomera, imbaraga za gel, hamwe nuguhagarara, birashobora kugenzurwa neza. Ubushyuhe bwa gel busanzwe mubusanzwe buri hagati ya 35 ° C na 60 ° C, mugihe ubushyuhe bwabwo bwo gushonga muri rusange ni 70 ° C kugeza 90 ° C. HPMC ikoreshwa cyane mu buhanga mu bya farumasi, kwisiga, n’ibiribwa bitewe n’imyitwarire idasanzwe ya georisiyo ihindagurika hamwe n’ubushyuhe bukabije.