Gutegura Hydroxypropyl Methylcellulose

Hydroxypropyl Methylcellulose (HPMC)ni amazi ya elegitoronike ya polymer yabonetse muburyo bwo guhindura imiti ya selile. Ikoreshwa cyane cyane mubijyanye na farumasi, ibiryo, amavuta yo kwisiga, nubwubatsi, kandi ifite ibintu byiza nko kubyimba, gukora firime, emulisation, no gutuza.

1. Ihame ryo kwitegura

Hydroxypropyl methylcellulose ni hydrophilique selulose ikomoka, kandi gukomera kwayo kwibasirwa cyane na hydroxypropyl hamwe na methyl insimburangingo muri molekile. Itsinda rya methyl ryongera imbaraga zamazi, mugihe hydroxypropyl itsinda ryongera umuvuduko waryo mumazi. Muri rusange, AnxinCel®HPMC irashobora gushonga vuba mumazi akonje kugirango ibe igisubizo kimwe cya colloidal, ariko igashonga buhoro mumazi ashyushye, kandi ibintu bya granulaire bikunze guhurira mugihe cyo gusesa. Niyo mpamvu, hagomba kwitonderwa kugenzura ubushyuhe bwo gusesa no gusesa mugihe cyo kwitegura.

2. Gutegura ibikoresho bibisi

Ifu ya HPMC: Hitamo ifu ya HPMC ifite ububobere butandukanye na dogere zo gusimbuza ukurikije ibisabwa kugirango ukoreshwe. Moderi isanzwe irimo ubukonje buke (uburemere buke bwa molekile) hamwe nubwiza bwinshi (uburemere buke bwa molekile). Guhitamo bigomba gushingira kubikenewe byihariye.

Umuti: Amazi nikoreshwa cyane mumashanyarazi, cyane cyane mugukoresha imiti nibiribwa. Ukurikije ibisabwa byo gusesa, hashobora no kuvangwa imvange y’amazi n’umuti ukomoka ku buhinzi, nka Ethanol / amazi avanze n’umuti.

3. Uburyo bwo kwitegura

Gupima HPMC
Ubwa mbere, bapima neza ifu ya HPMC isabwa ukurikije ubunini bwibisubizo bigomba gutegurwa. Mubisanzwe, urwego rwibanze rwa HPMC ni 0.5% kugeza 10%, ariko kwibanda kwihariye bigomba guhinduka ukurikije intego hamwe nubwiza bukenewe.

Gusesagura mbere
Kugirango wirinde ifu ya HPMC guteranya, mubisanzwe mbere yo guhanagura. Igikorwa cyihariye ni: kuminjagira ifu ya HPMC yapimye kuringaniza igice cyumuti, ukangure witonze, hanyuma utume ifu ya HPMC ihura nigitigiri gito cyumuti ubanza gushiraho leta itose. Ibi birashobora kubuza neza ifu ya HPMC guteranya no guteza imbere gutandukana kwayo.

Inzira yo guseswa
Buhoro buhoro ongeramo ibishishwa bisigaye kuri poro ya HPMC hanyuma ukomeze kubyutsa. Kubera ko HPMC ifite amazi meza, amazi na HPMC bishonga vuba mubushyuhe bwicyumba. Irinde gukoresha imbaraga nyinshi cyane mugihe cyo gukurura, kuko gukurura gukomeye bizatera ibibyimba gukora, bigira ingaruka kumucyo no guhuza igisubizo. Muri rusange, umuvuduko ukurura ugomba kubikwa murwego rwo hasi kugirango habeho guseswa kimwe.

Kugenzura ubushyuhe
Nubwo HPMC ishobora gushonga mumazi akonje, niba igipimo cyo kuyasesa gitinze, igisubizo kirashobora gushyuha muburyo bukwiye. Ubushyuhe bwo gushyuha bugomba kugenzurwa hagati ya 40 ° C na 50 ° C kugirango hirindwe ubushyuhe bukabije butera impinduka mumiterere ya molekile cyangwa impinduka zikomeye mubisubizo byubwiza bwumuti. Mugihe cyo gushyushya, gukurura bigomba gukomeza kugeza HPMC isheshwe burundu.

Gukonjesha no kuyungurura
Nyuma yo guseswa burundu, emera igisubizo gikonje bisanzwe mubushyuhe bwicyumba. Mugihe cyo gukonjesha, umubare muto wibibyimba cyangwa umwanda birashobora kugaragara mubisubizo. Nibiba ngombwa, akayunguruzo gashobora gukoreshwa mu kuyungurura kugirango ikureho ibice bikomeye kandi byemeze neza kandi bisobanutse neza.

Guhindura no kubika byanyuma
Igisubizo kimaze gukonja, intumbero yacyo irashobora guhinduka ukurikije ibikenewe nyabyo. Niba kwibumbira hamwe ari byinshi, igisubizo gishobora kongerwaho kugirango kigabanuke; niba kwibumbira hamwe ari bike cyane, ifu ya HPMC ikeneye kongerwamo. Igisubizo kimaze gutegurwa, kigomba gukoreshwa ako kanya. Niba ikeneye kubikwa igihe kirekire, igomba kubikwa mu kintu gifunze kugirango hirindwe amazi cyangwa umwanda.

4. Kwirinda

Kugenzura ubushyuhe: Ubushyuhe bwo hejuru bugomba kwirindwa mugihe cyo guseswa kugirango wirinde kugira ingaruka no gukomera kwa AnxinCel®HPMC. Ku bushyuhe bwinshi, HPMC irashobora gutesha agaciro cyangwa ububobere bwayo bushobora kugabanuka, bikagira ingaruka kumikoreshereze yabyo.

Uburyo bwo gukurura: Irinde kogosha cyane cyangwa kwihuta cyane kwihuta mugihe cyo gukurura, kuko gukurura cyane bishobora gutera ibibyimba gukora kandi bikagira ingaruka kumucyo wibisubizo.

Guhitamo ibishishwa: Amazi niyo akoreshwa cyane mumashanyarazi, ariko mubikorwa bimwe bidasanzwe, igisubizo kivanze cyamazi nandi mashanyarazi (nka alcool, acetone, nibindi) birashobora gutoranywa. Ibipimo bitandukanye bya solvent bizagira ingaruka ku gipimo cyo guseswa no gukora igisubizo.

Imiterere yububiko: Igisubizo cyateguwe na HPMC kigomba kubikwa ahantu hakonje kandi humye kugirango hirindwe igihe kirekire ubushyuhe bwinshi cyangwa urumuri rwizuba kugirango hirindwe impinduka mubwiza bwigisubizo.

Kurwanya keke: Iyo ifu yongewe kumuti, niba ifu yongewemo vuba cyangwa bitaringaniye, biroroshye gukora ibibyimba, bityo bigomba kongerwaho buhoro buhoro.

5. Imirima yo gusaba

Hydroxypropyl methylcellulose ikoreshwa cyane mu nganda zitandukanye kubera ubwiza bw’amazi meza hamwe na biocompatibilité:

Uruganda rwa farumasi: Nka firime yahoze, ifata, ikabyimbye, ikomeza kurekura, nibindi, nibiyobyabwenge, bigira uruhare runini mugutegura ibiyobyabwenge.

Inganda zibiribwa: Nkibyimbye, emulisiferi, stabilisateur, ikoreshwa kenshi mugutunganya ibiryo, nka ice cream, condiments, ibinyobwa, nibindi.

Inganda zubwubatsi: Nkubunini bwimyubakire yububiko hamwe na minisiteri, irashobora kunonosora imiterere namazi yimvange.

Amavuta yo kwisiga: Nkibyimbye, stabilisateur na firime byahoze, bikoreshwa mumavuta yo kwisiga nka cream, shampo, nibicuruzwa byuruhu kugirango bizamure ibicuruzwa nuburambe bwabakoresha.

Gutegura kwaHPMCni inzira isaba kwitondera amakuru arambuye. Mugihe cyo kwitegura, ibintu nkubushyuhe, uburyo bwo gukurura, hamwe no guhitamo ibishishwa bigomba kugenzurwa kugirango bishoboke gushonga kandi bikomeze gukora neza. Binyuze muburyo bwiza bwo gutegura, AnxinCel®HPMC irashobora gukoreshwa cyane mubikorwa byinshi kandi ikagira uruhare runini.