Incamake ya Hydroxypropyl Methylcellulose (HPMC)

Hydroxypropyl Methylcellulose (HPMC)ni intungamubiri ya selulose ikomoka hamwe na kimwe cya kabiri cyogukora polymer. Ikoreshwa cyane mu nganda nyinshi nk'ubwubatsi, ubuvuzi, ibiryo, kwisiga no gutwikira. Nka ether idafite ionic selulose ether, HPMC ifite amazi meza yo gukemura, ibintu bikora firime, gufatira hamwe na emulisifike, bityo ikaba ifite agaciro gakomeye mubikorwa byinshi.

1. Imiterere yimiti nimiterere ya HPMC

Imiterere ya molekuline ya HPMC ikomoka kuri selile naturel. Nyuma yo guhindura imiti, methyl (-OCH₃) na hydroxypropyl (-OCH₂CH₂OH) byinjizwa mumurongo wa selile. Imiterere shingiro yimiti nuburyo bukurikira:

Molekile ya selile igizwe nibice bya glucose bihujwe na β-1,4-glycosidic;

Amatsinda ya Methyl na hydroxypropyl yinjizwa mumurongo wa selile binyuze muburyo bwo gusimbuza.

Imiterere yimiti iha HPMC ibintu bikurikira:

Amazi meza: Mugucunga urugero rwo gusimbuza methyl na hydroxypropyl, HPMC irashobora guhindura amazi yayo. Muri rusange, HPMC irashobora gukora igisubizo kiboneka mumazi akonje kandi ifite amazi meza.

Guhindura Viscosity: Ubukonje bwa HPMC burashobora kugenzurwa neza muguhindura uburemere bwa molekile hamwe nurwego rwo gusimbuza kugirango byuzuze ibisabwa bitandukanye.

Kurwanya ubushyuhe: Kubera ko HPMC ari ibikoresho bya polimoplastike ya polimoplastique, ubushyuhe bwayo ni bwiza kandi burashobora gukomeza imikorere ihamye mubushyuhe runaka.

Biocompatibilité: HPMC ni ibintu bidafite uburozi kandi bidatera uburakari, bityo bikundwa cyane mubuvuzi.

2. Uburyo bwo gutegura HPMC

Uburyo bwo gutegura HPMC burangizwa ahanini na esterification reaction ya selile. Intambwe zihariye nizi zikurikira:

Iseswa rya selile: Icya mbere, vanga selile karemano hamwe na solve (nka chloroform, umusemburo wa alcool, nibindi) kugirango uyishonge mumuti wa selile.

Guhindura imiti: Methyl na hydroxypropyl reagent ya chimique (nkibintu bya chloromethyl hamwe na allyl alcool) byongewe kumuti kugirango bisubize reaction.

Kutabogama no gukama: Agaciro pH gahindurwa hongewemo aside cyangwa alkali, kandi gutandukana, kweza no gukama bikorwa nyuma yo kwitwara kugirango amaherezo abone hydroxypropyl methylcellulose.

3. Porogaramu nyamukuru ya HPMC

Imiterere yihariye ya HPMC ituma ikoreshwa cyane mubice byinshi. Ibikurikira nimwe mubice byingenzi bikoreshwa:

. Irashobora kunoza amazi, gufatira hamwe no kugumana amazi avanze. By'umwihariko muri minisiteri yumye, HPMC irashobora kunoza imikorere yubwubatsi, ikongera ifatira rya minisiteri, kandi ikirinda gucikamo ibice bya sima mugihe cyo gukomera.

(2) Umwanya wa farumasi: Mu rwego rwa farumasi, HPMC ikoreshwa mugutegura ibinini, capsules nibiyobyabwenge. Nkumukozi ukora firime, mubyimbye na stabilisateur, birashobora kunoza imiti no bioavailable yibiyobyabwenge. Mu bisate, HPMC ntishobora kugenzura gusa igipimo cyo kurekura ibiyobyabwenge, ahubwo ishobora no guteza imbere ibiyobyabwenge.

. Kurugero, mubiribwa birimo ibinure bike kandi bidafite amavuta, HPMC irashobora gutanga uburyohe bwiza nuburyo bwiza kandi bikongerera umutekano ibicuruzwa. Irakoreshwa kandi cyane mubiribwa bikonje kugirango birinde gutandukanya amazi cyangwa ibara rya kirisita.

. Irashobora kunoza imiterere yo kwisiga, ikaborohereza kuyikoresha no kuyikuramo. Cyane cyane mumavuta yuruhu, shampo, masike yo mumaso nibindi bicuruzwa, gukoresha HPMC birashobora kunoza imyumvire no gutuza kwibicuruzwa.

. Irashobora kandi kunoza uburyo bwo kurwanya amazi hamwe nuburyo bwo kurwanya ibicu, kandi bikongerera ubukana no gufatira hamwe.

4. Amahirwe yisoko niterambere ryiterambere rya HPMC

Nkuko abantu bitondera cyane kurengera ibidukikije nubuzima, HPMC, nkibikoresho bya polymer byatsi kandi bidafite uburozi, bifite ibyerekezo byinshi. Cyane cyane mu nganda zimiti, ibiribwa n’amavuta yo kwisiga, ikoreshwa rya HPMC rizagurwa kurushaho. Mu bihe biri imbere, gahunda yo kubyaza umusaruro HPMC irashobora kurushaho kunozwa, kandi kongera umusaruro no kugabanuka kw'ibiciro bizateza imbere ikoreshwa mu nganda nyinshi.

Hamwe niterambere ryibikoresho byubwenge hamwe nubuhanga bwo kurekura bugenzurwa, ikoreshwa rya HPMC muri sisitemu yo gutanga ibiyobyabwenge byubwenge nabyo bizahinduka ahantu h’ubushakashatsi. Kurugero, HPMC irashobora gukoreshwa mugutegura abatwara ibiyobyabwenge nibikorwa byo kurekura bigenzurwa kugirango bongere igihe cyibiyobyabwenge no kunoza imikorere.

Hydroxypropyl methylcelluloseni polymer ibikoresho nibikorwa byiza kandi bigari. Hamwe nogukoresha amazi meza cyane, ubushobozi bwo guhindura ibishishwa no guhuza ibinyabuzima byiza, HPMC ifite ibikorwa byingenzi mubice byinshi nkubwubatsi, ubuvuzi, ibiryo, amavuta yo kwisiga, nibindi. Hamwe niterambere ryubumenyi nikoranabuhanga, inzira yumusaruro hamwe nimirima ikoreshwa na HPMC irashobora gukomeza kwaguka, kandi ibyerekezo byiterambere biri imbere ni binini cyane.