Methylcellulose (MC) ni ubwoko bwa selile. Uturemangingo twa selulose ether ni inkomoko yabonetse muguhindura imiti ya selile karemano, kandi methylcellulose ninkomoko yingenzi ya selile yakozwe na methylating (methyl insimburangingo) hydroxyl igice cya selile. Kubwibyo, methylcellulose ntabwo ikomoka kuri selile gusa, ahubwo ni ether isanzwe ya selile.
1. Gutegura methylcellulose
Methylcellulose itegurwa no gukora selile hamwe na methylating agent (nka methyl chloride cyangwa dimethyl sulfate) mugihe cya alkaline kugirango methylate igice cya hydroxyl ya selile. Iyi myitwarire iboneka cyane mumatsinda ya hydroxyl kumwanya wa C2, C3 na C6 ya selile kugirango ikore methylcellulose hamwe nimpamyabumenyi zitandukanye zo gusimburwa. Inzira yo kubyitwaramo niyi ikurikira:
Cellulose (polysaccharide igizwe na glucose) ikorwa bwa mbere mugihe cya alkaline;
Noneho methylating agent itangizwa kugirango ikore etherification kugirango ibone methylcellulose.
Ubu buryo burashobora kubyara ibicuruzwa bya methylcellulose bifite viscosities zitandukanye hamwe nubushobozi bwo kwikemurira ibibazo muguhindura imiterere nigipimo cya methylation.
2. Ibyiza bya methylcellulose
Methylcellulose ifite ibintu by'ingenzi bikurikira:
Gukemura: Bitandukanye na selile isanzwe, methylcellulose irashobora gushonga mumazi akonje ariko ntibibe mumazi ashyushye. Ni ukubera ko kwinjiza methyl insimburangingo byangiza hydrogène ihuza molekile ya selile, bityo bikagabanya ububobere bwayo. Methylcellulose ikora igisubizo kiboneye mumazi kandi ikagaragaza imiterere ya gelation mubushyuhe bwinshi, ni ukuvuga ko igisubizo cyiyongera iyo gishyushye kandi kigarura amazi nyuma yo gukonja.
Kutagira uburozi: Methylcellulose ntabwo ari uburozi kandi ntabwo yinjizwa na sisitemu yo kurya. Kubwibyo, ikoreshwa kenshi mubiribwa ninyongeramusaruro yimiti nkibibyimbye, emulisiferi na stabilisateur.
Amabwiriza ya Viscosity: Methylcellulose ifite imiterere myiza yo kugenzura ibishishwa, kandi igisubizo cyacyo cyijimye kijyanye no gukemura hamwe nuburemere bwa molekile. Mugucunga urwego rwo gusimbuza reaction ya etherification, ibicuruzwa bya methylcellulose bifite ubunini butandukanye burashobora kuboneka.
3. Gukoresha methylcellulose
Bitewe nimiterere yihariye yumubiri nubumashini, methylcellulose yakoreshejwe cyane mubikorwa byinshi.
3.1 Inganda zibiribwa
Methylcellulose ninyongeramusaruro yibiribwa ikoreshwa mugutunganya ibiryo bitandukanye, cyane cyane kubyimbye, emulisiferi na stabilisateur. Kubera ko methylcellulose ishobora kuza iyo ishyushye ikagarura amazi nyuma yo gukonja, ikoreshwa kenshi mubiribwa bikonje, ibicuruzwa bitetse hamwe nisupu. Byongeye kandi, imiterere-ya-calorie nkeya ya methylcellulose ituma iba ingirakamaro mubintu bimwe na bimwe bya karori nkeya.
3.2 Inganda zimiti nubuvuzi
Methylcellulose ikoreshwa cyane mu nganda zimiti, cyane cyane mubikorwa bya tablet, nkibintu byoroshye kandi bihuza. Bitewe nubushobozi bwiza bwo guhindura ibishishwa, birashobora kunoza neza imbaraga za mashini hamwe no gusenya ibintu bya tableti. Byongeye kandi, methylcellulose ikoreshwa kandi nk'ibikoresho byo kurira mu buryo bw'amaso mu kuvura amaso yumye.
3.3 Inganda zubaka nibikoresho
Mu bikoresho byubaka, methylcellulose ikoreshwa cyane muri sima, gypsumu, ibifuniko hamwe nudusimba nkibibyimbye, bigumana amazi na firime yahoze. Bitewe no gufata neza amazi, methylcellulose irashobora kunoza imikorere nogukoresha ibikoresho byubwubatsi kandi ikirinda kubyara ibice nubusa.
3.4 Inganda zo kwisiga
Methylcellulose nayo isanzwe ikoreshwa mubikorwa byo kwisiga nkibyimbye na stabilisateur kugirango ifashe gukora emulisiyo ndende na geles. Irashobora kunoza ibyiyumvo byibicuruzwa no kongera ingaruka nziza. Ni hypoallergenic kandi yoroheje, kandi ibereye uruhu rworoshye.
4. Kugereranya methylcellulose nizindi selile
Ether ya selile ni umuryango mugari. Usibye methylcellulose, hari na selile ya Ethyl (EC), hydroxypropyl methylcellulose (HPMC), hydroxyethyl selulose (HEC) nubundi bwoko. Itandukaniro ryabo nyamukuru riri mubwoko no kurwego rwo gusimbuza insimburangingo kuri molekile ya selile, igena imbaraga zabyo, ibishishwa hamwe n’ahantu hashyirwa.
Methylcellulose vs Hydroxypropyl Methylcellulose (HPMC): HPMC ni verisiyo nziza ya methylcellulose. Usibye insimburangingo ya methyl, hydroxypropyl nayo iratangizwa, bigatuma solubilité ya HPMC itandukanye. HPMC irashobora gushonga mubushuhe bwagutse, kandi ubushyuhe bwayo bwumuriro burenze ubwa methylcellulose. Kubwibyo, mubikoresho byubwubatsi ninganda zimiti, HPMC ifite uburyo bwagutse bwo gusaba.
Methylcellulose vs Ethyl Cellulose (EC): Ethyl selulose ntishobora gushonga mumazi, ariko irashonga mumashanyarazi. Bikunze gukoreshwa mubikoresho bikomeza-kurekura ibikoresho byo gutwikira hamwe nibiyobyabwenge. Methyl selulose irashobora gushonga mumazi akonje kandi ikoreshwa cyane nkibikoresho byongera amazi. Ahantu ho gukoreshwa haratandukanye nubwa Ethyl selulose.
5. Iterambere ryiterambere rya selile
Hamwe no gukenera ibikoresho birambye hamwe n’imiti y’icyatsi, ibibyimba bya selile ya selile, harimo na methyl selulose, bigenda bihinduka igice cyingenzi cyibikoresho byangiza ibidukikije. Ikomoka kuri fibre yibimera karemano, irashobora kuvugururwa, kandi irashobora kwangirika mubidukikije. Mugihe kizaza, ahantu hashyirwa ingufu za selile ya selile irashobora kwagurwa, nko mumbaraga nshya, inyubako zicyatsi na biomedicine.
Nubwoko bwa selile ether, methyl selulose ikoreshwa cyane mubikorwa byinshi kubera imiterere yihariye yumubiri nubumara. Ntabwo ifite imbaraga zo kwikemurira gusa, kutagira uburozi, nubushobozi bwiza bwo guhindura ibishishwa, ariko kandi igira uruhare runini mubiribwa, ubuvuzi, ubwubatsi no kwisiga. Mu bihe biri imbere, hamwe n’ibikenerwa n’ibikoresho byangiza ibidukikije, ibyifuzo bya methyl selulose bizaba binini.
Igihe cyo kohereza: Ukwakira-23-2024