Hydroxypropyl MethylcelluloseA Incamake Yuzuye

Hydroxypropyl methylcellulose (HPMC)ni polymer itandukanye isanga ikoreshwa cyane mubikorwa bitandukanye, harimo imiti, ibiryo, ubwubatsi, hamwe no kwisiga. Uru ruganda, rukomoka kuri selile, rutanga ibintu byihariye nko kubyimba, guhuza, gukora firime, no gukomeza gusohora.

1. Imiterere n'imiterere

HPMC ni kimwe cya kabiri cyogukora, polymer-soluble polymer ikomoka kuri selile. Ihinduranya mukuvura selile hamwe na okiside ya propylene na methyl chloride, bikavamo gusimbuza amatsinda ya hydroxyl hamwe na hydroxypropyl hamwe nitsinda ryimikorere. Urwego rwo gusimbuza (DS) rwaya matsinda ruratandukanye, bigira ingaruka kumiterere ya HPMC.

Kubaho kwa hydroxypropyl hamwe na matsinda mato bitanga ibintu byinshi byingenzi kuri HPMC:

Amazi meza: HPMC irashonga mumazi akonje, ikora igisubizo gisobanutse neza. Gukemura biterwa nibintu nka DS, uburemere bwa molekile, n'ubushyuhe.

Gukora firime: HPMC irashobora gukora firime zoroshye, zibonerana mugihe zashizwe mubisubizo byamazi. Izi firime zisanga porogaramu mu miti ya farumasi, igenzurwa na matrices yo gusohora, na firime ziribwa mu nganda zibiribwa.

Umubyimba: Ibisubizo bya HPMC byerekana imyitwarire ya pseudoplastique, aho ububobere bugabanuka hamwe no kongera umuvuduko wogosha. Uyu mutungo utuma ukoreshwa nkumubyimba muburyo butandukanye, harimo amarangi, ibifatika, nibicuruzwa byawe bwite.

Kurekura kuramba: Bitewe no kubyimba no gutwarwa nisuri, HPMC ikoreshwa cyane muri sisitemu yo gutanga imiti irekuye. Igipimo cyo kurekura ibiyobyabwenge kirashobora guhuzwa no guhindura polymer yibanze, DS, nibindi bipimo.

2. Synthesis

Synthesis ya HPMC ikubiyemo intambwe nyinshi:

Etherification: Cellulose ivurwa hamwe nuruvange rwa oxyde ya propylene na alkali, bigatuma habaho amatsinda ya hydroxypropyl.

Methylation: Hydroxypropylated selulose irongera ikorwa na methyl chloride kugirango itangire amatsinda mato.

Urwego rwo gusimburwa rushobora kugenzurwa no guhindura imiterere yimyitwarire, nkikigereranyo cya reagent, igihe cyo kubyitwaramo, nubushyuhe. Indangagaciro za DS zo hejuru ziganisha kuri hydrophilicity no gukemuka kwa HPMC.

3. Porogaramu

HPMC isanga porogaramu zikoreshwa mu nganda zitandukanye:

Imiti ya farumasi: Muburyo bwa farumasi, HPMC ikora nka binder, disintegrant, coating agent, na matrix yahoze muburyo bwa dosiye igenzurwa. Irakoreshwa cyane mubinini, capsules, imyiteguro y'amaso, hamwe nibisobanuro byingenzi.

Ibiryo: HPMC ikoreshwa mubicuruzwa byibiribwa nkibibyimbye, stabilisateur, emulifier, hamwe nubushakashatsi bwa firime. Itezimbere ubwiza, umunwa, hamwe nogukomeza ibicuruzwa mubicuruzwa nka sosi, isupu, desert, nibicuruzwa bitetse.

Ubwubatsi: Mubikoresho byubwubatsi, HPMC ikora nkibikoresho byo kubika amazi, kubyimbye, no guhindura rheologiya muri minisiteri ishingiye kuri sima, ibyuma bifata amabati, plaster, nibicuruzwa bya gypsumu. Itezimbere gukora, gufatana, hamwe nigihe cyo gufungura iyi formulaire.

Amavuta yo kwisiga: HPMC yinjizwa mu mavuta yo kwisiga no kwita ku muntu ku giti cye nk'ikibyimbye, filime yahoze, na emulisiferi mu mavuta, amavuta yo kwisiga, shampo, na mascara. Itanga uburyo bworoshye, butajegajega, kandi bugenzurwa kurekura ibintu bikora.

Izindi nganda: HPMC nayo ikoreshwa mugucapura imyenda, impapuro, impuzu, hamwe nubuhinzi bitewe nuburyo butandukanye.

4. Ibizaza

Biteganijwe ko HPMC iziyongera cyane mu myaka iri imbere, bitewe nimpamvu nyinshi:

Udushya twa farumasi: Hamwe no kwibanda kuri sisitemu yo gutanga imiti nubuvuzi bwihariye, imiti ishingiye kuri HPMC irashobora kubona iterambere rikomeje. Kugenzura-kurekura tekinoroji, nanomedicine, hamwe nubuvuzi butanga inzira zitanga ibyiringiro bya HPMC.

Icyatsi cya Chemistry Initiative: Mugihe impungenge z’ibidukikije zigenda ziyongera, hari kwiyongera kubidukikije byangiza ibidukikije kandi byangiza ibidukikije. HPMC, ikomoka kumasoko ya selile ishobora kuvugururwa, ihuza intego zirambye kandi yiteguye gusimbuza polymrike ya synthique mubikorwa byinshi.

Ubuhanga buhanitse bwo gukora: Iterambere mubikorwa byubwubatsi, polymer chimie, na nanotehnologiya bituma umusaruro wa HPMC ufite imitungo idahwitse kandi imikorere myiza. Ibikomoka kuri Nanocellulose, ibikoresho, hamwe nubuhanga bwo gucapa 3D bifite ubushobozi bwo kwagura porogaramu ya HPMC.

Ahantu nyaburanga: Inzego zishinzwe kugenzura amategeko zishyiraho amabwiriza akomeye ku ikoreshwa rya polymers mu nganda zitandukanye, cyane cyane mu bya farumasi n’ibiribwa. Kubahiriza umutekano, ubuziranenge, hamwe nibirango ibisabwa bizaba ingenzi kubabikora nababashinzwe gukoreshaHPMCmu bicuruzwa byabo.

hydroxypropyl methylcellulose (HPMC) igaragara nka polymer itandukanye kandi ikoreshwa muburyo butandukanye muri farumasi, ibiryo, ubwubatsi, kwisiga, nizindi nganda. Imiterere yihariye, harimo gukemura amazi, ubushobozi bwo gukora firime, kubyibuha, hamwe nubushobozi burambye bwo kurekura, bituma iba ingenzi muburyo butandukanye. Hamwe nubushakashatsi bukomeje, iterambere ryikoranabuhanga, no kongera ubumenyi burambye, HPMC yiteguye kugira uruhare runini muguhindura ibikoresho bizaza no guhanga udushya.