Hydroxypropyl methylcellulose-HPMC

Hydroxypropyl methylcellulose (HPMC)ni ibice byinshi hamwe nibisabwa byinshi mubikorwa bitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, ubwubatsi, nibindi byinshi.

Ibigize imiti n'imiterere:
HPMC ni igice cya sintetike, inert, viscoelastic polymer ikomoka kuri selile ikoresheje guhindura imiti. Igizwe no gusubiramo ibice bya molekile ya glucose, isa na selile, hamwe na hydroxypropyl hamwe na methyl matsinda yometse kumugongo wa selile. Urwego rwo gusimbuza (DS) rwaya matsinda rugena imiterere ya HPMC, harimo kwikemurira ibibazo, kwiyegeranya, hamwe nimyitwarire ya gelation.

Uburyo bwo gukora:
Synthesis ya HPMC ikubiyemo intambwe nyinshi. Mu ikubitiro, selile ivurwa na alkali kugirango ikore amatsinda ya hydroxyl. Ibikurikira, okiside ya propylene ikorwa hamwe na selile ikora kugirango itangire hydroxypropyl. Ubwanyuma, methyl chloride ikoreshwa muguhuza amatsinda ya methyl na hydroxypropylated selulose, bikavamo HPMC. DS ya hydroxypropyl na methyl irashobora kugenzurwa mugihe cyo gukora kugirango ihuze imitungo ya HPMC kubikorwa byihariye.

Ibyiza bifatika:
HPMC ni ifu yera kugeza yera yera ifite amazi meza cyane. Irashobora gushonga mumazi akonje kandi ashyushye, ikora ibisubizo bisobanutse neza. Ubwiza bwibisubizo bya HPMC biterwa nibintu nkuburemere bwa molekile, urugero rwo gusimbuza, hamwe no kwibanda. Byongeye kandi, HPMC yerekana imyitwarire ya pseudoplastique, bivuze ko ububobere bwayo bugabanuka mugihe cyogosha, bigatuma bikenerwa mubisabwa nko kubyimba ibintu, stabilisateur, no gukora firime.

Porogaramu:
Imiti:HPMCikoreshwa cyane mubikorwa bya farumasi nka binder, firime yahoze, idahwitse, kandi igenzurwa-kurekura ibinini, capsules, hamwe nibisobanuro byingenzi. Imiterere yacyo, guhuza nibikoresho bikora bya farumasi (APIs), hamwe nubushobozi bwo guhindura imiti irekura ibiyobyabwenge bituma iba ikintu cyingenzi muri sisitemu yo gutanga ibiyobyabwenge.

Inganda zikora ibiribwa: Mu nganda z’ibiribwa, HPMC ikoreshwa nkibyimbye, emulifisiyeri, stabilisateur, hamwe na gelling agent mubicuruzwa bitandukanye nka sosi, imyambarire, desert, nibintu byokerezwamo imigati. Itezimbere ubwiza, yongera umunwa, kandi itanga ituze ryibiryo bidahinduye uburyohe cyangwa umunuko.

Amavuta yo kwisiga: HPMC yinjizwa muburyo bwo kwisiga nka firime yahoze, ikabyimbye, kandi igahagarika ibintu mumavuta, amavuta yo kwisiga, shampo, nibindi bicuruzwa byita kumuntu. Itanga ibishishwa, ikongera ikwirakwizwa, kandi igateza imbere ibicuruzwa mugihe itanga uruhu rwiza kandi rutunganya uruhu n umusatsi.

Inganda zubaka: Mu nganda zubwubatsi, HPMC ikoreshwa nkumubyimba, kubika amazi, no kongera imbaraga mumashanyarazi ashingiye kuri sima, ibyuma bifata amabati, plaster, na grout. Itezimbere imikorere, igabanya gutandukanya amazi, kandi ikongerera imbaraga, bikavamo ibikoresho byubaka kandi biramba cyane.

Ibindi bikorwa: HPMC isanga porogaramu mubice bitandukanye nko gucapa imyenda, ububumbyi, gushushanya amarangi, nibikomoka ku buhinzi. Ikora nkumubyimba, guhindura imvugo, hamwe na binder muribi bikorwa, bigira uruhare mubikorwa byubuziranenge.

Hydroxypropyl methylcellulose (HPMC)ni polymer ikora cyane hamwe nibikorwa byinshi mubikorwa bitandukanye bitewe nuburyo bwihariye bwo guhuza imitungo, harimo gukemura amazi, kugenzura ibishishwa, ubushobozi bwo gukora firime, hamwe na biocompatibilité. Guhinduranya kwinshi no guhuza nibintu bitandukanye bituma iba ingenzi mubintu bya farumasi, ibikomoka ku biribwa, kwisiga, nibikoresho byubwubatsi, nibindi. Mugihe ubushakashatsi niterambere ryikoranabuhanga bikomeje, ibikorwa bya HPMC biteganijwe ko bizagenda byiyongera, biteza imbere udushya no kuzamura umusaruro mubicuruzwa bitandukanye.