Hydroxypropyl methylcellulose gel ubushyuhe

Hydroxypropyl methylcellulose (HPMC)ni polymer itandukanye ikoreshwa cyane mubikorwa bya farumasi, ibiribwa, amavuta yo kwisiga, hamwe ninganda zikoreshwa. HPMC ihabwa agaciro kubushobozi bwayo bwo gukora geles, firime, hamwe no gukemura amazi. Nyamara, ubushyuhe bwimiterere ya HPMC burashobora kuba ikintu cyingenzi mubikorwa byacyo no mubikorwa bitandukanye. Ibibazo bijyanye nubushyuhe nkubushyuhe bwa gelation, ihinduka ryijimye, hamwe nimyitwarire yo kwikemurira ibibazo bishobora guhindura ibicuruzwa byanyuma nibikorwa bihamye.

Gusobanukirwa Hydroxypropyl Methylcellulose (HPMC)

Hydroxypropyl methylcellulose ninkomoko ya selile aho amwe mumatsinda ya hydroxyl ya selile asimbuzwa hydroxypropyl na methyl. Ihinduka ryongerera imbaraga za polymer mumazi kandi ritanga kugenzura neza imiterere yimiterere nubwiza. Imiterere ya polymer itanga ubushobozi bwo gukora gele mugihe mubisubizo byamazi, bigatuma iba ikintu cyiza mubikorwa bitandukanye.

HPMC ifite umutungo wihariye: ikora gelation kubushyuhe bwihariye iyo ishonga mumazi. Imyitwarire ya gelation ya HPMC iterwa nibintu nkuburemere bwa molekile, urugero rwo gusimbuza (DS) ya hydroxypropyl na methyl matsinda, hamwe na polymer yibisubizo.

Ubushyuhe bwa Gelation ya HPMC

Ubushyuhe bwa gelation bivuga ubushyuhe HPMC ihura nicyiciro kiva mumazi kijya muri gel. Iki nikintu cyingenzi muburyo butandukanye, cyane cyane kubicuruzwa bya farumasi no kwisiga aho bisabwa guhuza neza nuburyo bwiza.

Imyitwarire ya gelation ya HPMC mubusanzwe irangwa nubushyuhe bukomeye bwa gelation (CGT). Iyo igisubizo gishyushye, polymer ihura na hydrophobique itera guteranya no gukora gel. Nyamara, ubushyuhe ibi bibaho burashobora gutandukana ukurikije ibintu byinshi:

Uburemere bwa molekile: Uburemere buri hejuru ya HPMC ikora geles mubushyuhe bwinshi. Ibinyuranye, uburemere buke bwa molekile HPMC ikora geles mubushyuhe buke.

Impamyabumenyi yo gusimburwa (DS): Urwego rwo gusimbuza amatsinda ya hydroxypropyl na methyl birashobora kugira ingaruka kubushyuhe n'ubushyuhe. Urwego rwo hejuru rwo gusimbuza (methyl nyinshi cyangwa hydroxypropyl groupe) mubisanzwe bigabanya ubushyuhe bwimiterere, bigatuma polymer irushaho gushonga kandi ikitabira ihinduka ryubushyuhe.

Kwibanda.

Kubaho kwa Ions: Mubisubizo byamazi, ion zirashobora kugira ingaruka kumyitwarire ya HPMC. Kuba umunyu cyangwa izindi electrolytite zirashobora guhindura imikoranire ya polymer namazi, bikagira ingaruka kubushyuhe bwayo. Kurugero, kongeramo sodium chloride cyangwa umunyu wa potasiyumu birashobora kugabanya ubushyuhe bwa gelation mukugabanya hydrasi yiminyururu ya polymer.

pH: PH yumuti irashobora kandi kugira ingaruka kumyitwarire ya gelation. Kubera ko HPMC itabogamye mubihe byinshi, impinduka za pH mubisanzwe zigira ingaruka nkeya, ariko urwego pH rukabije rushobora gutera kwangirika cyangwa guhindura ibiranga gelation.

Ibibazo by'ubushyuhe muri HPMC Gelation

Ibibazo byinshi bijyanye nubushyuhe birashobora kugaragara mugihe cyo gutegura no gutunganya geles zishingiye kuri HPMC:

1. Kwiyegereza imburagihe

Kwiyegereza imburagihe bibaho mugihe polymer itangiye kuza mubushyuhe buke kurenza uko byifuzwa, bikagorana gutunganya cyangwa kwinjiza mubicuruzwa. Iki kibazo gishobora kuvuka niba ubushyuhe bwa gelation buri hafi yubushyuhe bwibidukikije cyangwa ubushyuhe bwo gutunganya.

Kurugero, mugukora gel ya farumasi cyangwa cream, niba igisubizo cya HPMC gitangiye kuza mugihe cyo kuvanga cyangwa kuzuza, birashobora gutera inzitizi, imiterere idahuye, cyangwa gukomera udashaka. Ibi nibibazo cyane mubikorwa binini binini, aho bikenewe kugenzura neza ubushyuhe.

2. Gelation ituzuye

Kurundi ruhande, gelation ituzuye ibaho mugihe polymer itaje nkuko byari byateganijwe kubushyuhe bwifuzwa, bikavamo ibicuruzwa bitemba cyangwa bidafite ubukana buke. Ibi birashobora kubaho bitewe nuburyo butari bwo bwumuti wa polymer (nko kwibanda nabi cyangwa uburemere bwa molekile idakwiye HPMC) cyangwa kugenzura ubushyuhe budahagije mugihe cyo gutunganya. Gelation ituzuye ikunze kugaragara mugihe polymer yibanze cyane, cyangwa igisubizo ntigere kubushyuhe bukenewe mugihe gihagije.

3. Ubushyuhe budasanzwe

Guhungabana k'ubushyuhe bivuga gusenyuka cyangwa kwangirika kwa HPMC mubihe by'ubushyuhe bwo hejuru. Mugihe HPMC ihagaze neza, kumara igihe kinini guhura nubushyuhe bwo hejuru birashobora gutera hydrolysis ya polymer, bikagabanya uburemere bwa molekile, bityo, ubushobozi bwayo. Iyangirika ryumuriro riganisha kumiterere ya gel idakomeye kandi ihinduka mumiterere yumubiri wa gel, nkubwiza buke.

4. Imihindagurikire

Ihindagurika rya Viscosity ni iyindi mbogamizi ishobora kubaho hamwe na geles ya HPMC. Ubushyuhe butandukanye mugihe cyo gutunganya cyangwa kubika birashobora gutera ihindagurika ryijimye, biganisha ku bwiza bwibicuruzwa bidahuye. Kurugero, iyo bibitswe mubushyuhe bwo hejuru, gel irashobora kuba inanutse cyane cyangwa ikabyimbye cyane bitewe nubushyuhe bwakorewe. Kugumana ubushyuhe buhoraho bwo gutunganya ni ngombwa kugirango habeho ubukonje buhamye.

Imbonerahamwe: Ingaruka yubushyuhe kuri HPMC Imiterere ya Gelation

Ibisubizo byo gukemura Ubushyuhe bujyanye nibibazo

Kugabanya ibibazo bijyanye n'ubushyuhe muburyo bwa HPMC, ingamba zikurikira zirashobora gukoreshwa:

Hindura uburemere bwa Molecular hamwe nimpamyabumenyi yo gusimburwa: Guhitamo uburemere bwa molekuline hamwe nintera yo gusimbuza ibyateganijwe birashobora gufasha kwemeza ko ubushyuhe bwa gelation buri murwego rwifuzwa. Uburemere buke bwa molekuline HPMC irashobora gukoreshwa mugihe hakenewe ubushyuhe buke bwa gelation.

Igenzura: Guhindura ubunini bwa HPMC mubisubizo birashobora gufasha kugenzura ubushyuhe bwa gelation. Ubushuhe bwinshi muri rusange butera gel gukora ubushyuhe buke.

Gukoresha Ubushyuhe-Kugenzurwa Gutunganya: Mu nganda, kugenzura neza ubushyuhe ni ngombwa kugirango wirinde gusohora imburagihe cyangwa ituzuye. Sisitemu yo kugenzura ubushyuhe, nkubushyuhe bwo kuvanga ibigega hamwe na sisitemu yo gukonjesha, birashobora kwemeza ibisubizo bihamye.

Shyiramo Stabilisateur hamwe na hamwe: Kwiyongera kwa stabilisateur cyangwa co-solvets, nka glycerol cyangwa polyoli, birashobora gufasha kuzamura ubushyuhe bwumuriro wa geles ya HPMC no kugabanya ihindagurika ryijimye.

Kurikirana pH n'imbaraga za Ionic: Ni ngombwa kugenzura imbaraga za pH na ionic zumuti kugirango wirinde impinduka zitifuzwa mumyitwarire ya gelation. Sisitemu ya buffer irashobora gufasha kubungabunga ibihe byiza byo gukora gel.

Ibibazo bijyanye n'ubushyuhe bifitanye isanoHPMCgeles ningirakamaro kugirango ikemure kugirango igere ku bicuruzwa byiza, haba mu bya farumasi, kwisiga, cyangwa ibiryo. Gusobanukirwa nibintu bigira ingaruka ku bushyuhe bwa gelation, nkuburemere bwa molekile, kwibanda, hamwe no kuba hari ion, nibyingenzi muburyo bwiza bwo gukora no gukora. Kugenzura neza ubushyuhe bwo gutunganya hamwe nibipimo byerekana birashobora gufasha kugabanya ibibazo nko guhindagurika imburagihe, gelation ituzuye, hamwe nihindagurika ryijimye, byemeza ko ibicuruzwa bikomoka kuri HPMC bihagaze neza.