Gusobanukirwa Hydroxypropyl Methyl Cellulose (HPMC)
Hydroxypropyl Methyl Cellulose (HPMC) ni polymer itandukanye ikoreshwa cyane mubikorwa bitandukanye, harimo imiti, ibiryo, amavuta yo kwisiga, nubwubatsi. Imiterere yihariye, nko gukama amazi, guhindagurika hejuru yubushyuhe, hamwe nubushobozi bwo gukora firime, bituma iba ingirakamaro mubintu byinshi. Imwe mu miterere ikomeye ya HPMC nubukonje bwayo, bigira ingaruka zikomeye kumikorere no kuyishyira mubikorwa.
Ibintu bigira ingaruka kuri Viscosity ya HPMC
Ibintu byinshi bigira ingaruka kumyumvire ya HPMC, harimo:
Uburemere bwa molekuline: Uburemere buke bwa molekile amanota ya HPMC muri rusange yerekana ububobere buke.
Kwishyira hamwe: Ubukonje bwiyongera hamwe na HPMC yibisubizo.
Ubushyuhe: Ubushuhe buragabanuka hamwe nubushyuhe bwiyongera kubera iminyururu ya polymer igenda igendanwa.
pH: HPMC ihagaze neza mugari ya pH, ariko urwego pH rukabije rushobora kugira ingaruka kumyuka.
Impamyabumenyi yo gusimbuza (DS) no gusimbuza Molar (MS): Urwego rwo gusimbuza (umubare w'amatsinda ya hydroxyl yasimbujwe na mikorobe cyangwa hydroxypropyl matsinda) no gusimbuza amara (umubare w'amatsinda ya hydroxypropyl kuri glucose) bigira ingaruka ku gukomera no kwiyegeranya kwa HPMC
Viscosity ikwiye kubikorwa bitandukanye
Ubukonje bukwiye bwa HPMC biterwa na porogaramu yihariye. Hano reba birambuye uburyo ibisabwa bya viscosity bitandukanye mubikorwa bitandukanye:
1. Imiti
Muri farumasi, HPMC ikoreshwa nka binder, firime-yahoze, kandi igenzurwa-kurekura ibinini na capsules.
Ipitingi ya Tablet: Ubukonje buke kandi buciriritse HPMC (igisubizo cya 3-5% hamwe na 50-100 cps) ikwiranye na firime, itanga urwego rworoshye, rukingira.
Kurekurwa kugenzurwa: Ubukonje bukabije HPMC (1% igisubizo hamwe na 1.500-100.000 cps) ikoreshwa mububiko bwa matrix kugirango igenzure igipimo cyo kurekura ibintu bikora, bituma irekurwa rirambye mugihe runaka.
Binder muri Granulation: Hagati ya viscosity HPMC (2% igisubizo hamwe na 400-4,000 cps) ihitamo uburyo bwo guhunika amazi kugirango ibe granules n'imbaraga nziza za mashini.
Inganda zikora ibiribwa
Mu nganda zibiribwa, HPMC ikoreshwa nkibyimbye, stabilisateur, na emulifier.
Umukozi wibyimbye: Ubukonje buke kugeza hagati HPMC (1-2% igisubizo hamwe na 50-4,000 cps) ikoreshwa mukubyimba isosi, imyambarire, hamwe nisupu.
Emulsifier na Stabilisateur: Ubukonje buke HPMC (1% igisubizo hamwe na 10-50 cps) ikwiranye no guhagarika emulisiyo hamwe nifuro, itanga ubwiza bwifuzwa mubicuruzwa nka ice cream hamwe no gukubita ibiboko.
3. Amavuta yo kwisiga no kwita ku muntu ku giti cye
HPMC ikoreshwa mu kwisiga kugirango ibyibushye, ikora firime, hamwe nubushuhe.
Amavuta yo kwisiga hamwe na cream: HPMC yo hasi kugeza hagati (1% igisubizo hamwe na 50-4,000 cps) itanga ihame ryifuzwa kandi rihamye.
Ibicuruzwa byita kumisatsi: Hagati ya viscosity HPMC (1% igisubizo hamwe na 400-4,000 cps) ikoreshwa muri shampo hamwe na kondereti kugirango utezimbere imikorere.
4. Inganda zubaka
Mu bwubatsi, HPMC nigice cyingenzi mubicuruzwa nka tile yometseho, plaster, nibikoresho bishingiye kuri sima.
Amatafari ya Tile hamwe na Grout: Hagati ya viscosity HPMC (2% igisubizo hamwe na 4,000-20,000 cps) itezimbere imikorere, kubika amazi, hamwe nibiranga.
Amasima ya sima: Hagati ya viscosity HPMC (1% igisubizo hamwe na 400-4,000 cps) byongera gufata amazi no gukora, bikarinda gucika no kunoza kurangiza.
Ibipimo bya Viscosity n'ibipimo
Viscosity ya HPMC isanzwe ipimwa hakoreshejwe viscometer, kandi ibisubizo bigaragarira muri centipoise (cps). Uburyo busanzwe nka Brookfield viscometry cyangwa capillary viscometrie ikoreshwa bitewe nurwego rwijimye. Guhitamo icyiciro gikwiye cya HPMC kiyobowe nibisobanuro byatanzwe nababikora, birimo imyirondoro irambuye.
Ibitekerezo bifatika
Mugihe uhitamo HPMC kubisobanuro byihariye, ibitekerezo byinshi bifatika bigomba kwitabwaho:
Gutegura igisubizo: Kuvomera neza no gusesa nibyingenzi kugirango ugere kubwiza bwifuzwa. Kwiyongera buhoro buhoro kumazi hamwe no gukurura bikomeza bifasha kurinda ibibyimba.
Guhuza: Guhuza HPMC nibindi bikoresho bigize formulaire bigomba kugeragezwa kugirango habeho umutekano no gukora neza.
Imiterere yo kubika: Viscosity irashobora guterwa nububiko nkubushyuhe nubushuhe. Kubika neza ahantu hakonje, humye ni ngombwa kugirango ubungabunge ubuziranenge bwa HPMC.
Ubukonje bukwiye bwa Hydroxypropyl Methyl Cellulose (HPMC) buratandukanye cyane bitewe nuburyo bukoreshwa, uhereye ku bwenge buke bwo kwifata no guhagarika ibicuruzwa by’ibiribwa kugeza ubwo bwenge bwinshi bwo gusohora imiti igenzurwa muri farumasi. Gusobanukirwa ibisabwa byihariye bya buri nganda nibisabwa ni ngombwa muguhitamo icyiciro cyiza cya HPMC, kwemeza imikorere myiza nibikorwa. Urebye ibintu nkuburemere bwa molekuline, kwibanda, ubushyuhe, na pH, ababikora barashobora guhuza ibisubizo bya HPMC kugirango babone ibyo bakeneye.
Igihe cyo kohereza: Gicurasi-22-2024