HPMC / HPS ivanze-ubukonje bwa gel

Hydroxypropyl methylcellulose (HPMC)firime ifite imikorere myiza, ariko kubera ko HPMC ari gel yumuriro, ubukonje bwubushyuhe buke buri hasi cyane, ibyo ntibishobora gutwikira (cyangwa kwibiza) no gukama mubushyuhe buke kugirango utegure firime iribwa, bikavamo imikorere mibi yo gutunganya; mubyongeyeho, igiciro cyacyo kinini kigabanya imikoreshereze yacyo. Hydroxypropyl krahisi (HPS) ni gele ikonje ihendutse, iyongeweho irashobora kongera ubukonje bwa HPMC mubushyuhe buke, kunoza imikorere ya HPMC, no kugabanya igiciro cyumusaruro, byongeye, hydrophilicity imwe, ibice bya glucose hamwe nitsinda rya hydroxypropyl byose bigira uruhare mukuzamura ubwuzuzanye bwaba polymers bombi. Kubwibyo, sisitemu yo kuvanga geli ishyushye-ikonje yateguwe muguhuza HPS na HPMC, kandi ingaruka zubushyuhe kumiterere ya gel ya sisitemu ya HPMC / HPS ya hot-ubukonje ya gel ivanze yakozwe muburyo bukoreshwa hakoreshejwe rheometero hamwe nuburyo buto bwo gukwirakwiza X-ray. , ihujwe ningaruka zuburyo bwo kuvura ubushyuhe kuri microstructure hamwe nimiterere ya sisitemu ya membrane, hanyuma yubaka isano iri hagati yimiterere ya gel yimiterere ya sisitemu ya membrane-imiterere-membrane imiterere-ya membrane mubihe byo kuvura ubushyuhe.

Ibisubizo byerekana ko ku bushyuhe bwo hejuru, gel hamwe na hejuruHPMCibirimo bifite modulus ihanitse kandi ifite akamaro gakomeye-nkimyitwarire, imiterere-isa-yimiterere ya gel ikwirakwiza ni denser, kandi ubunini bwa gel hamwe ni bunini; ku bushyuhe buke, ibirimo bya HPS Urugero rwa gel rwinshi rufite modulus yo hejuru, igaragara cyane imyitwarire isa nki, hamwe na denser yonyine-imiterere yimiterere ya gel. Kuburugero rufite igipimo kimwe cyo kuvanga, modulus hamwe nimyitwarire isa ningirakamaro yimyitwarire hamwe nuburinganire bwimiterere ya geles yiganjemo HPMC mubushyuhe bwo hejuru irarenze iziganjemo HPS mubushyuhe buke. Ubushyuhe bwo kumisha burashobora kugira ingaruka kumiterere ya geli ya sisitemu mbere yo gukama, hanyuma bikagira ingaruka kumiterere ya kristalline nuburyo bwa amorphous ya firime, hanyuma amaherezo bikagira ingaruka zikomeye kumiterere ya firime, bikavamo imbaraga zingana na modulus ya firime yumye kubushyuhe bwinshi. Hejuru kuruta yumye ku bushyuhe buke. Igipimo cyo gukonjesha nta ngaruka zigaragara kigaragara kuri sisitemu ya sisitemu, ariko kigira ingaruka ku bucucike bwa microdomain umubiri usa na firime. Muri ubu buryo, ubwinshi bwimiterere isa na firime irashobora kugira ingaruka kumiterere ya firime. Imikorere ifite ingaruka zikomeye.

Hashingiwe ku itegurwa rya membrane ivanze, ubushakashatsi bwerekanye ko gukoresha igisubizo cya iyode muguhitamo guhitamo irangi rya HPMC / HPS ryashizeho uburyo bushya bwo kureba neza ikwirakwizwa ryicyiciro hamwe ninzibacyuho ya sisitemu ivanze munsi ya microscope. buryo, bufite uburyo bwo kuyobora bufite akamaro ko kwiga icyiciro cyo gukwirakwiza sisitemu yo kuvanga. Hifashishijwe ubu buryo bushya bwubushakashatsi, bufatanije na infragre ya sprosroscopi, scanning electron microscopi na extensometer, inzibacyuho yicyiciro, guhuza hamwe nubukanishi bwa sisitemu byasesenguwe kandi byigwa, kandi guhuza, guhuza ibyiciro no kugaragara kwa firime byubatswe. isano hagati yimikorere. Ibisubizo byo kureba microscope byerekana ko sisitemu ihura nicyiciro mugihe igipimo cya HPS ari 50%, kandi kuvanga intera interineti bibaho muri firime, byerekana ko sisitemu ifite urwego runaka rwo guhuza; infragre, isesengura rya thermogravimetric hamwe na SEM ibisubizo birusheho kugenzura kuvanga. Sisitemu ifite urwego runaka rwo guhuza. Modulus ya firime ivanze ihinduka mugihe ibirimo HPS ari 50%. IyoHPSibirimo birenze 50%, impande zifatika zicyitegererezo zivanze zitandukana kumurongo ugororotse uhuza inguni zifatika zicyitegererezo cyiza, kandi iyo kiri munsi ya 50%, itandukana nabi kuva kumurongo ugororotse. , biterwa ahanini ninzibacyuho.