Nigute ushobora gukoresha hydroxypropyl methylcellulose no kwirinda

1. Intangiriro kuri hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC)ni selile idafite ionic selile yakozwe mubikoresho bya polymer bisanzwe binyuze muburyo bwo guhindura imiti. Ikoreshwa cyane mubwubatsi, imiti, ibiryo, kwisiga, gutwikira no mubindi bice, kandi ifite imirimo myinshi nko kubyimba, kubika amazi, gukora firime, no gufatira hamwe.

2. Nigute wakoresha hydroxypropyl methylcellulose

Gushonga amazi akonje
AnxinCel®HPMC irashobora gukwirakwizwa mu mazi akonje, ariko kubera hydrophilique yayo, biroroshye gukora ibibyimba. Birasabwa kumena buhoro buhoro HPMC mumazi akonje kugirango ukwirakwize kandi wirinde guhuriza hamwe.

Gushonga amazi ashyushye
Nyuma yo guhanagura HPMC n'amazi ashyushye, ongeramo amazi akonje kugirango ubyimbye kugirango ube igisubizo kimwe. Ubu buryo burakwiriye cyane-viscosity HPMC.

Kuvanga ifu yumye
Mbere yo gukoresha HPMC, irashobora kuvangwa neza hamwe nibindi bikoresho byifu byifu, hanyuma bigakangurwa bigashonga namazi.

Inganda zubaka
Ifu ya pompe na putty, inyongera ya HPMC muri rusange 0.1% ~ 0.5%, ikoreshwa cyane mugutezimbere amazi, imikorere yubwubatsi ndetse no kurwanya anti-sagging.

Inganda zimiti
HPMC ikoreshwa kenshi mububiko bwa tablet hamwe na matrix ihoraho-irekura, kandi dosiye yayo igomba guhinduka ukurikije formulaire yihariye.

Inganda zikora ibiribwa
Iyo ikoreshejwe nk'ibyimbye cyangwa emulisiferi mu biryo, ibipimo bigomba kubahiriza ibipimo byumutekano wibiribwa, muri rusange 0.1% ~ 1%.

Kwambara
Iyo HPMC ikoreshejwe mumazi ashingiye kumazi, irashobora kunoza umubyimba no gutandukana kwifuniko kandi ikarinda kugwa kwimvura.

Amavuta yo kwisiga
HPMC ikoreshwa nka stabilisateur mu mavuta yo kwisiga kugirango itezimbere kandi ihindagurika ryibicuruzwa.

3. Kwirinda gukoresha hydroxypropyl methylcellulose

Igihe cyo gusenyuka no kugenzura ubushyuhe
HPMC ifata igihe runaka cyo gushonga, mubisanzwe iminota 30 kugeza kumasaha 2. Ubushyuhe buri hejuru cyane cyangwa buke cyane bizagira ingaruka ku gipimo cyo guseswa, kandi ubushyuhe bukwiye hamwe nubushyuhe bugomba guhitamo ukurikije ibihe byihariye.

Irinde guhuriza hamwe
Iyo wongeyeho HPMC, igomba gutatana buhoro kandi ikabyutswa neza kugirango birinde agglomeration. Niba agglomeration ibaye, igomba gusigara yonyine mugihe runaka hanyuma ikabyutsa nyuma yo kubyimba rwose.

Ingaruka z’ubushuhe bw’ibidukikije
HPMC yunvikana nubushuhe kandi ikunda kwibasirwa nubushuhe hamwe nubushuhe mubidukikije. Kubwibyo, hagomba kwitonderwa gukama kububiko kandi ibipfunyika bigomba gufungwa.

Kurwanya aside na alkali
HPMC ihagaze neza kuri acide na alkalis, ariko irashobora kwangirika muri acide ikomeye cyangwa ibidukikije bya alkali, bikagira ingaruka kumikorere yayo. Kubwibyo, ibihe bya pH bikabije bigomba kwirindwa bishoboka mugihe cyo gukoresha. 

Guhitamo uburyo butandukanye
HPMC ifite moderi zitandukanye (nk'ubukonje bwinshi, ubukonje buke, gushonga vuba, nibindi), kandi imikorere n'imikoreshereze yabo biratandukanye. Mugihe uhisemo, icyitegererezo gikwiye kigomba gutoranywa ukurikije ibintu byihariye bisabwa (nkibikoresho byubaka, imiti, nibindi) nibikenewe.

Isuku n'umutekano
Iyo ukoresheje AnxinCel®HPMC, ibikoresho byo gukingira bigomba kwambara kugirango wirinde guhumeka umukungugu.

Iyo ikoreshejwe mubiribwa nubuvuzi, igomba kubahiriza amabwiriza nubuziranenge bwinganda zibishinzwe.

Guhuza nibindi byongeweho

Iyo bivanze nibindi bikoresho muri formula, hagomba kwitonderwa guhuza kwayo kugirango birinde imvura, coagulation cyangwa izindi ngaruka mbi.

4. Kubika no gutwara

Ububiko
HPMCbigomba kubikwa ahantu hakonje, humye, hirindwa ubushyuhe bwinshi nubushuhe. Ibicuruzwa bidakoreshwa bigomba gufungwa.

Ubwikorezi
Mugihe cyo gutwara, igomba kurindwa imvura, ubushuhe nubushyuhe bwinshi kugirango birinde kwangirika kubipakira.

Hydroxypropyl methylcellulose nibikoresho byinshi bya chimique bisaba gusesa siyanse kandi yumvikana, kongeraho no kubika mubikorwa bifatika. Witondere kwirinda agglomeration, kugenzura imiterere yo gusesa, hanyuma uhitemo icyitegererezo hamwe na dosiye ukurikije ibihe bitandukanye byo gusaba kugirango wongere imikorere yayo. Muri icyo gihe, amahame yinganda agomba gukurikizwa byimazeyo kugirango HPMC ikoreshwe neza kandi neza.