Ingaruka ya HPMC kumikorere yo kwipimisha minisiteri

Kwiyoroshya-minisiteri irashobora kwishingikiriza kuburemere bwayo kugirango ibe umusingi uringaniye, woroshye kandi ukomeye kuri substrate yo gushyira cyangwa guhuza ibindi bikoresho. Mugihe kimwe, irashobora gukora ubwubatsi bunini kandi bunoze. Kubwibyo, amazi menshi ni ikintu cyingenzi cyane cyo kwishyiriraho ibipimo byiyongereyeho, bigomba kuba bifite amazi amwe n'imbaraga zo guhuza, nta kintu cyo gutandukanya amazi, kandi gifite ibimenyetso biranga ubushyuhe n'ubushyuhe buke.

Mubisanzwe, minisiteri yo kwisuzumisha isaba amazi meza, ariko amazi ya paste ya sima mubyukuri ni 10-12cm gusa; muriselile ethers, hydroxypropyl methylcellulose (HPMC) ninyongera nyamukuru ya minisiteri ivanze, nubwo amafaranga yiyongereye ari make cyane, irashobora kunoza imikorere yimikorere ya minisiteri, irashobora kunoza imikorere, imikorere, guhuza ibikorwa hamwe no gufata amazi ya minisiteri. Ifite uruhare runini mubijyanye na minisiteri ivanze.

1. Kugenda

Hydroxypropyl methylcellulose (HPMC)ifite uruhare runini mukubika amazi, guhoraho no kubaka ubwubatsi bwa minisiteri. Cyane cyane nka minisiteri yo kwipimisha, fluidite nimwe mubipimo nyamukuru byo gusuzuma imikorere yo kwipimisha. Hashingiwe ku kwemeza ibisanzwe bisanzwe bya minisiteri, amazi ya minisiteri arashobora guhinduka muguhindura ingano ya HPMC. Ariko, niba dosiye ari ndende cyane, amazi ya minisiteri azagabanuka, bityo dosiye ya HPMC igomba kugenzurwa mugihe gikwiye.

Kubika amazi

Kugumana amazi ya minisiteri nigipimo cyingenzi cyo gupima ihame ryimiterere yimbere yimbere ya sima ivanze. Kugirango ukore neza reaction ya hydration yibikoresho bya gel, ingano ya HPMC irashobora kugumana ubuhehere buri muri minisiteri igihe kirekire. Muri rusange, igipimo cyo gufata amazi ya slurry cyiyongera hamwe no kwiyongera kwa HPMC. Igikorwa cyo gufata amazi ya HPMC kirashobora kubuza insimburangingo gufata amazi menshi vuba, kandi bikabuza guhinduka kwamazi, kugirango harebwe niba ibidukikije bitemba bitanga amazi ahagije yo kuvomera sima. Byongeye kandi, ubwiza bwa hydroxypropyl methylcellulose nabwo bugira uruhare runini mu kugumana amazi ya minisiteri. Iyo hejuru yubukonje, niko gufata amazi neza. Mubisanzwe, ibicuruzwa bifite viscosity ya 400mpa.s ahanini bikoreshwa muburyo bwo kwipima uburinganire, bushobora kunoza imikorere iringaniza ya minisiteri kandi bikongerera ubushobozi bwa minisiteri.

3. Gushiraho igihe

HPMC ifite ingaruka zimwe zo kudindiza kuri minisiteri. Hamwe no kwiyongera kwa dosiye, igihe cyo gushiraho minisiteri ni ndende. Ingaruka mbi ya HPMC kuri paste ya sima ahanini biterwa nurwego rwo gusimbuza amatsinda ya alkyl, kandi ntaho ihuriye nuburemere bwa molekile. Gutoya urwego rwo gusimbuza alkyl, nini ya hydroxyl, niko bigaragara ingaruka zo kudindiza. Kandi hejuru yibirimo HPMC, niko bigaragara cyane ingaruka za firime igoye kurwego rwo hejuru ya hydrataire ya sima, bityo ingaruka zo kudindiza nazo ziragaragara.

4. Imbaraga zoroshye nimbaraga zo kwikuramo

Mubisanzwe, imbaraga nimwe mubipimo byingenzi byo gusuzuma kugirango bikire ingaruka zo gukiza ibikoresho bya sima bishingiye ku sima. Imbaraga zo guhonyora hamwe nimbaraga zoroshye za minisiteri bizagabanuka hamwe no kwiyongera kwa HPMC.

5. Guhuza imbaraga

HPMC igira uruhare runini mubikorwa byo guhuza minisiteri.HPMCikora firime ya polymer ifite ingaruka zifunga hagati ya sisitemu ya feri ya feri na sima ya hydrata ya sima, iteza amazi menshi muri firime ya polymer hanze ya sima, ifasha hydratiya yuzuye ya sima, bityo bikazamura ubwiza bwa slurry. Gukomera k'ubucuti. Muri icyo gihe, wongeyeho urugero rukwiye rwa HPMC byongera plastike nubworoherane bwa minisiteri, bigabanya ubukana bwakarere kinzibacyuho hagati ya minisiteri na substrate, kandi bigabanya ubushobozi bwo kunyerera hagati yimbere. Ku rugero runaka, ingaruka zo guhuza hagati ya minisiteri na substrate zongerewe. Mubyongeyeho, kubera kubaho kwa HPMC muri paste ya sima, hashyizweho akarere kihariye kinzibacyuho nintera yimbere hagati yibice bya minisiteri nibicuruzwa bitanga amazi. Isohora ryimiterere ituma intera yinzibacyuho ihinduka cyane kandi idakomeye. Kubwibyo, Mortar ifite imbaraga zikomeye zo guhuza.