Waba uzi imikorere ya hydroxypropyl methylcellulose?

Hydroxypropyl methylcelluloseni ubwoko bwa selile idafite ionic ivanze ether. Bitandukanye na ionic methyl carboxymethyl selulose ivanze ether, ntabwo ikora hamwe nibyuma biremereye. Bitewe numubare utandukanye wibintu bya vitokisile hamwe na hydroxypropyl yibirimo muri hydroxypropyl methylcellulose hamwe na viscosities zitandukanye, hariho ubwoko bwinshi bufite imitungo itandukanye, kurugero, ibinyabuzima byinshi bya vitamine hamwe nibirimo hydroxypropyl bike Imikorere yayo yegereye iya methyl selile, mugihe imikorere ya hydroxypropyl iri hafi ya hydroxypropyl. Nyamara, muri buri bwoko, nubwo umubare muto wa hydroxypropyl cyangwa itsinda rito rya metoxyl urimo, hariho itandukaniro rinini mubishobora gukemuka mumashanyarazi cyangwa ubushyuhe bwa flocculation mubisubizo byamazi.

(1) Imiterere ya hydroxypropyl methylcellulose

Ububasha bwa hydroxypropyl methylcellulose mumaziHydroxypropyl methylcellulosemubyukuri ni ubwoko bwa methylcellulose yahinduwe na okiside ya propylene (mikorerexy-propylene), bityo iracyafite ibintu bimwe na methyl selulose ifite ibintu bisa nibiranga amazi akonje hamwe nubushyuhe bwamazi ashyushye. Nyamara, bitewe na hydroxypropyl yahinduwe, ubushyuhe bwayo bwo mumazi ashyushye burenze kure ubwa methyl selile. Kurugero, ubwiza bwa hydroxypropyl methylcellulose yumuti wamazi hamwe na 2% ya vitamine yo gusimbuza DS = 0,73 hamwe na hydroxypropyl yibirimo MS = 0.46 ni 500 mpa · s kuri 20 ° C, nubushyuhe bwa gel irashobora kugera kuri 100 ° C, mugihe methyl selulose mubushyuhe bumwe ni nka 55 ° C. Kubijyanye no gukomera kwayo mumazi, nayo yaratejwe imbere cyane. Kurugero, hydroxypropyl methylcellulose ya pulverized (imiterere ya granulaire 0.2 ~ 0.5mm kuri 20 ° C hamwe na 4% yumuti wamazi wa 2pa • s urashobora kugurwa mubushyuhe bwicyumba, byoroshye gushonga mumazi udakonje.

Ububasha bwa hydroxypropyl methylcellulose mumashanyarazi kama yumuti wa hydroxypropyl methylcellulose mumashanyarazi ya organic nayo iruta iya methylcellulose. Methylcellulose ikeneye kugira urwego rwo gusimbuza metoxyl ya 2.1 Ibicuruzwa byavuzwe haruguru, ariko birimo hydroxypropyl MS = 1.5 ~ 1.8 na mikorobe DS = 0.2 ~ 1.0, hydroxypropyl methylcellulose ifite urugero rwinshi rwo gusimbuza hejuru ya 1.8 irashonga muri methanol ya anhidrous na etanol yumuti, hamwe nubushyuhe bwamazi. Irashobora kandi gushonga muri hydrocarbone ya chlorine nka methylene chloride na chloroform, hamwe na solge organic nka acetone, isopropanol na alcool ya diacetone. Gukemura kwayo mumashanyarazi kama nibyiza kuruta amazi.

. Ipimwa kuri 20 ° C hamwe na 2% yumuti wamazi nkibisanzwe. Ubukonje bwibicuruzwa bimwe byiyongera hamwe no kwiyongera kwibitekerezo. Kubicuruzwa bifite uburemere butandukanye bwa molekuline kumurongo umwe, ibicuruzwa bifite uburemere bunini bwa molekile bifite ubwiza bwinshi. Isano yayo nubushyuhe isa nubwa methyl selulose. Iyo ubushyuhe buzamutse, ibishishwa bitangira kugabanuka, ariko iyo bigeze ku bushyuhe runaka, ubukonje burazamuka gitunguranye kandi gelation iba. Ubushyuhe bwa gel bwibicuruzwa biri hasi cyane. ni hejuru. Ingingo ya gel yayo ntabwo ifitanye isano gusa nubwiza bwa ether gusa, ahubwo ifitanye isano nigipimo cyimiterere yitsinda rya mikorerexyl hamwe na hydroxypropyl groupe muri ether nubunini bwurwego rusimburwa. Twabibutsa ko hydroxypropyl methylcellulose nayo ari pseudoplastique, kandi igisubizo cyacyo kikaba gihamye mubushyuhe bwicyumba nta kwangirika kwijimye keretse hashobora kubaho kwangirika kwimisemburo.

. Umunyu rusange nka chloride, bromide, fosifate, nitrate, nibindi ntibizagwa iyo byongewe kumuti wamazi. Nyamara, kongeramo umunyu bigira uruhare runini mubushyuhe bwa flocculation yumuti wamazi. Iyo umunyu wiyongereye, ubushyuhe bwa gel buragabanuka. Iyo umunyu mwinshi uri munsi ya flocculation, ubwiza bwumuti bukunda kwiyongera. Kubwibyo, umubare munini wumunyu wongeyeho, mubishyira mubikorwa, birashobora kugera ku mubyimba mwinshi mubukungu. Kubwibyo, mubisabwa bimwe, nibyiza gukoresha imvange ya selulose ether numunyu kuruta kwibanda cyane kumuti wa ether kugirango ugere kumubyimba.

. Irashobora kwihanganira urugero runaka rwa acide yumucyo, nka acide formique, acide acike, acide citric, acide succinic, aside fosifori, aside boric, nibindi. Ariko aside yibanze ifite ingaruka zo kugabanya ubukonje. Alkalis nka soda ya caustic, potas ya caustic n'amazi ya lime nta ngaruka bigira kuri yo, ariko birashobora kongera ubworoherane bwumuti wumuti, hanyuma bikagabanuka buhoro buhoro.

. Ibi bikoresho bya polymer birimo polyethylene glycol, acetate ya polyvinyl, polysilicone, polymethylvinyl siloxane, hydroxyethyl selile, na methyl selulose. Ibintu bisanzwe bya molekuliyumu nka gum arabic, inzige ibishyimbo, karaya gum, nibindi nabyo bihuza neza nigisubizo cyacyo. Hydroxypropyl methylcellulose irashobora kandi kuvangwa na ester ya mannitol cyangwa sorbitol ester ya acide stearic cyangwa aside palmitike, kandi ishobora no kuvangwa na glycerine, sorbitol na mannitol, kandi ibyo bikoresho bishobora gukoreshwa nka hydroxypropyl methylcellulose Plasticizer ya selile.

(6) Amazi adashongaselile ethersya hydroxypropyl methylcellulose irashobora gukora uburinganire bwambukiranya na aldehydes, kugirango izo ether zishonga mumazi zigwa mumuti hanyuma zidashonga mumazi. Aldehydes ituma hydroxypropyl methylcellulose idashobora gushonga harimo formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, nibindi. Iyo ukoresheje formaldehyde, hakwiye kwitabwaho byumwihariko agaciro ka pH kumuti, aho glyoxal ikora vuba mubikorwa byinganda. Igipimo cyubwoko nkubu bwo guhuza ibikorwa mubisubizo ni 0.2% ~ 10% ya misa ya ether, nibyiza 7% ~ 10%, kurugero, 3.3% ~ 6% ya glyoxal niyo ikwiye cyane. Mubisanzwe, ubushyuhe bwo kuvura ni 0 ~ 30 ℃, kandi igihe ni 1 ~ 120min. Igisubizo cyo guhuza ibitekerezo kigomba gukorwa mugihe cya acide. Mubisanzwe, pH yumuti ihindurwamo hafi 2 ~ 6 wongeyeho aside ikomeye ya organic organique cyangwa acide karubasi ya acide kama yumuti, byaba byiza hagati ya 4 ~ 6, hanyuma aldehydes ikongerwaho kugirango ikore reaction ihuza. Acide yakoreshejwe ifite aside hydrochloric, aside sulfurike, aside fosifori, aside aside, aside acike, aside hydroxy-acetike, aside succinic cyangwa acide citric nibindi, aho usanga hamwe na acide formique cyangwa acide acike, kandi aside irike nibyiza. Acide na aldehyde birashobora kandi kongerwaho icyarimwe kugirango byemere igisubizo kunyuranya-reaction ihuza pH yifuza. Iyi reaction ikoreshwa kenshi muburyo bwa nyuma bwo kuvura mugutegura selile ya selile. Nyuma ya selile ether idashobora gukemuka, biroroshye gukoresha.

20 ~ 25 ℃ amazi yo gukaraba no kwezwa. Iyo ibicuruzwa biri gukoreshwa, ibintu bya alkaline birashobora kongerwaho igisubizo cyibicuruzwa kugirango uhindure pH yumuti kugirango ube alkaline, kandi ibicuruzwa bizashonga mubisubizo byihuse. Ubu buryo burakoreshwa no kuvura firime nyuma yumuti wa selulose ether ikozwe muri firime kugirango ikore firime idashonga.

. erode kumatsinda ya anhydroglucose idafite ishingiro kugirango ikore isukari, nkintungamubiri za mikorobe ikurura. Kubwibyo, niba urwego rwo gusimbuza etherification ya selile yiyongereye, kurwanya isuri yimisemburo ya selile ya ether nayo iziyongera. Nk’uko raporo zibyerekana, mu gihe cyagenzuwe, ibisubizo bya hydrolysis biva mu misemburo yakozwe, ubukonje busigaye bwa hydroxypropyl methylcellulose (DS = 1.9) ni 13.2%, methylcellulose (DS = 1.83) ni 7.3%, methylcellulose (DS = 1.66) ni 3,8%, na hydroxyethyl selile ni 1,7%. Birashobora kugaragara ko hydroxypropyl methylcellulose ifite ubushobozi bukomeye bwo kurwanya enzyme. Kubwibyo, enzyme nziza irwanya hydroxypropyl methylcellulose, ifatanije nogukwirakwiza kwayo neza, kubyimba no gukora firime, ikoreshwa mubitambaro byamazi-emuliyoni, nibindi, kandi mubisanzwe ntabwo ikeneye kongeramo imiti igabanya ubukana. Ariko, kububiko bwigihe kirekire bwibisubizo cyangwa ibishoboka byanduye bivuye hanze, imiti igabanya ubukana irashobora kongerwaho muburyo bwo kwirinda, kandi guhitamo birashobora kugenwa ukurikije ibisabwa bya nyuma byigisubizo. Fenilmercuric acetate na fluorosilicate ya manganese birinda ibintu neza, ariko byose bifite Uburozi, bigomba kwitabwaho kubikorwa. Mubisanzwe, 1 ~ 5mg ya acetate ya fenylmercury irashobora kongerwaho igisubizo kuri litiro ya dosiye.

(8) Imikorere yahydroxypropyl methylcellulosefirime Hydroxypropyl methylcellulose ifite ibyiza byo gukora film. Umuti wacyo wamazi cyangwa igisubizo kama kama gishyizwe kumasahani yikirahure, kandi gihinduka ibara kandi kibonerana nyuma yo gukama. Kandi firime ikomeye. Ifite ubushyuhe bwiza kandi ikomeza gukomera ku bushyuhe bwinshi. Niba hiyongereyeho plasitiki ya hygroscopique, kurambura no guhinduka birashobora kwiyongera. Mu rwego rwo kunoza imiterere, plasitike nka glycerine na sorbitol nibyo byiza cyane. Mubisanzwe, ibisubizo byibisubizo ni 2% ~ 3%, naho plastiseri ni 10% ~ 20% ya selile ya ether. Niba ibirimo plasitike ari byinshi, kugabanuka kwa colloidal dehydrasiyo bizabaho mubushuhe bwinshi. Imbaraga zingana za firime hamwe na plasitike yongeweho nini cyane kuruta iyo idafite plastike, kandi iriyongera hamwe no kwiyongera kwamafaranga yiyongereye. Kubijyanye na hygroscopicity ya firime, nayo iriyongera hamwe no kwiyongera kwa plastike.