Itandukaniro hagati ya Hydroxypropyl Methylcellulose na Hydroxyethyl Cellulose

Hydroxypropyl Methylcellulose (HPMC) naHydroxyethyl Cellulose (HEC) ni byombi bikomoka kuri selile, bikoreshwa cyane mu nganda, ubuvuzi, kwisiga no mu zindi nzego. Itandukaniro ryabo nyamukuru rigaragarira muburyo bwa molekile, imiterere yo gukemura, imirima ikoreshwa nibindi bintu.

1. Imiterere ya molekile

Hydroxypropyl Methylcellulose (HPMC)

HPMC ni ibishishwa byamazi yatangijwe no kwinjiza methyl (-CH3) na hydroxypropyl (-CH2CHOHCH3) mumatsinda ya selile ya selile. By'umwihariko, imiterere ya molekuline ya HPMC irimo ibintu bibiri bisimburana, methyl (-OCH3) na hydroxypropyl (-OCH2CH (OH) CH3). Mubisanzwe, igipimo cyo kwinjiza methyl kiri hejuru, mugihe hydroxypropyl irashobora kunoza neza imbaraga za selile.

Hydroxyethyl Cellulose (HEC)

HEC ni inkomoko yatangijwe no kwinjiza amatsinda ya Ethyl (-CH2CH2OH) mumurongo wa selile ya selile. Mu miterere ya hydroxyethyl selulose, itsinda rimwe cyangwa byinshi hydroxyl (-OH) ya selile isimburwa nitsinda rya hydroxyl ya Ethyl (-CH2CH2OH). Bitandukanye na HPMC, imiterere ya molekile ya HEC ifite hydroxyethyl imwe gusa kandi ntabwo irimo amatsinda ya methyl.

2. Amazi meza

Bitewe nuburyo butandukanye, imiterere y'amazi ya HPMC na HEC iratandukanye.

HPMC: HPMC ifite amazi meza cyane, cyane cyane kubutagira aho bubogamiye cyangwa alkaline nkeya pH, gukemura kwayo ni byiza kuruta HEC. Kwinjiza amatsinda ya methyl na hydroxypropyl byongera imbaraga zayo kandi birashobora no kongera ubukana bwayo binyuze mumikoranire ya molekile y'amazi.

HEC: Ubusanzwe HEC irashobora gushonga mumazi, ariko gukemura kwayo birakennye cyane cyane mumazi akonje, kandi akenshi bikenera gushonga mugihe cyubushyuhe cyangwa bigasaba kwibanda cyane kugirango bigerweho ningaruka zijimye. Gukemura kwayo bifitanye isano nuburyo butandukanye bwa selile na hydrophilicity ya hydroxyethyl groupe.

3. Viscosity n'imiterere ya rheologiya

HR Mubitekerezo bitandukanye, HPMC irashobora gutanga ihinduka kuva mubucucike buke kugeza hejuru cyane, kandi ibishishwa byumva cyane impinduka za pH.

HEC: Ubukonje bwa HEC burashobora kandi guhindurwa muguhindura intumbero, ariko igipimo cyayo cyo guhindura ibicucu ni gito kuruta icya HPMC. HEC ikoreshwa cyane cyane mubihe bikenewe ubukonje buke kugeza hagati, cyane cyane mubwubatsi, ibikoresho byo kwisiga hamwe nibicuruzwa byita kumuntu. Imiterere ya rheologiya ya HEC irahagaze neza, cyane cyane muri acide cyangwa idafite aho ibogamiye, HEC irashobora gutanga ubukonje buhamye.

4. Imirima yo gusaba

Hydroxypropyl methylcellulose (HPMC)

Inganda zubwubatsi: HPMC isanzwe ikoreshwa mumasima ya sima hamwe nudukingirizo mubikorwa byubwubatsi kugirango bitezimbere amazi, imikorere no gukumira ibice.

Inganda zimiti: Nkumukozi ushinzwe kugenzura ibiyobyabwenge, HPMC ikoreshwa cyane munganda zimiti. Ntishobora gukoreshwa gusa nkigikoresho cyo gukora ibinini na capsules, ariko kandi nkigikoresho gifasha ibiyobyabwenge kurekura neza.

Inganda zibiribwa: HPMC ikoreshwa mugutunganya ibiryo nka stabilisateur, kubyimbye cyangwa emulisiferi kugirango itezimbere uburyohe bwibiryo.

Inganda zo kwisiga: Nkibyimbye, HPMC ikoreshwa cyane mubicuruzwa nka cream, shampo, na kondereti kugirango byongere ubwiza no guhagarara neza kubicuruzwa.

Hydroxyethyl selulose (HEC)

Inganda zubaka: HEC ikoreshwa kenshi muri sima, gypsumu, hamwe na tile yomeka kugirango iteze imbere kandi igumane ibicuruzwa.

Isuku: HEC ikoreshwa kenshi mubisukura urugo, ibikoresho byo kumesa nibindi bicuruzwa kugirango byongere ubwiza bwibicuruzwa no kunoza ingaruka zogusukura.

Inganda zo kwisiga: HEC ikoreshwa cyane mubicuruzwa byita ku ruhu, geles yo koga, shampo, nibindi nkibyimbye kandi bihagarika kugirango bitezimbere imiterere nibicuruzwa.

Gukuramo amavuta: HEC irashobora kandi gukoreshwa mugikorwa cyo gukuramo amavuta nkikibyimbye mumazi ashingiye kumazi kugirango afashe kongera ububobere bwamazi no kunoza ingaruka zo gucukura.

5. pH ituze

HPMC: HPMC yunvikana cyane nimpinduka za pH. Mugihe cya acide, imbaraga za HPMC ziragabanuka, zishobora kugira ingaruka kumikorere. Kubwibyo, mubisanzwe bikoreshwa mubutabogamye kugeza kuri alkaline nkeya.

HEC: HEC ikomeje kuba ihagaze hejuru ya pH yagutse. Ifite imiterere ihindagurika yibidukikije bya acide na alkaline, kubwibyo ikoreshwa kenshi muburyo busaba gushikama gukomeye.

HPMCnaHECitandukanye muburyo bwa molekulike, gukemura, imikorere yoguhindura imikorere, hamwe nibisabwa. HPMC ifite amazi meza yo gukemura no guhindura imikorere, kandi irakwiriye kubisabwa bisaba ubwiza bwinshi cyangwa imikorere yihariye yo kurekura; mugihe HEC ifite pH ihagaze neza hamwe nurwego runini rwibisabwa, kandi irakwiriye mubihe bisaba ubukonje buciriritse kandi buke hamwe n’ibidukikije bihindagurika. Mubikorwa bifatika, guhitamo ibikoresho bigomba gusuzumwa ukurikije ibikenewe byihariye.