Ibiranga tekinoroji yubushyuhe bwo hejuru kuri hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC)ni ibikoresho byingenzi bya shimi, bikoreshwa cyane mubikoresho byubaka, ubuvuzi, ibiryo nizindi nzego. Cyane cyane mubikorwa byubwubatsi, HPMC ikoreshwa cyane kubera imikorere yayo myiza. Ikoranabuhanga ryubushyuhe bwo hejuru rifite uruhare runini mugukora no gukoresha HPMC.

1. Uruhare rwa tekinoroji yubushyuhe bwo hejuru muri HPMC

umusaruroHydroxypropyl methylcellulose iboneka hamwe nuruhererekane rwimiti nka alkalisation na etherification ya selile naturel. Ikoranabuhanga ryubushyuhe bwo hejuru rikoreshwa cyane cyane mu gusesa, gukama no kubumba ibyiciro bya reaction. Kuvura ubushyuhe bwo hejuru ntibishobora kwihutisha igipimo cyibisubizo gusa, ahubwo binatezimbere ubuziranenge nuburinganire bwibicuruzwa.

Kunoza imikorere

Mugihe cy'ubushyuhe bwo hejuru, umuvuduko wa selile na hydroxide ya sodium wihuta, ibyo bigatuma hydroxypropyl na methyl isimburana muri molekile ya selile, bityo bikazamura urwego rwo gusimbuza (DS) hamwe nuburinganire bwa HPMC.

Kuraho umwanda

Ubushyuhe bwo hejuru burashobora gukuraho neza ibicuruzwa byakozwe mugihe cyibisubizo, nkibisubizo bya alkali idakemuwe hamwe na solvent, kandi bikanoza ubuziranenge bwa HPMC.

Kunoza imikorere yumye

Mugihe cyo kumisha ubushyuhe bwinshi, ubuhehere bwa HPMC bugenda bwuka vuba, birinda ibicuruzwa guhunika cyangwa gutandukana mubushyuhe buke, no kunoza imikorere nububiko bwibicuruzwa.

2. Ingaruka zikoranabuhanga ryubushyuhe bwo hejuru kumikorere ya HPMC

Tekinoroji yubushyuhe bwo hejuru ntabwo igira ingaruka kumiterere ya HPMC gusa, ahubwo inagira ingaruka zikomeye kumiterere yimiti ningaruka zikoreshwa.

Guhindura ibice

Ubushyuhe bwo hejuru burashobora kugenzura neza ikwirakwizwa ryibiro bya HPMC, bityo bigahindura ububobere bwayo. Ubushyuhe bwo hejuru bufasha kugabanya amahirwe yo kuvunika urunigi, bigatuma ubwiza bwa HPMC mubisubizo byamazi bihamye.

Kongera ubushyuhe

Ubushyuhe bwumuriro wa HPMC bwateye imbere cyane binyuze mubushyuhe bwo hejuru. Mu kubaka amabuye ya minisiteri na tile, HPMC irashobora gukomeza gufata neza hamwe no kurwanya imiti igabanuka mugihe cy'ubushyuhe bwinshi.

Kunoza ibisubizo

Mugihe cyo kumisha ubushyuhe bwo hejuru, microstructure ya HPMC iba nziza, bigatuma irushaho gukomera mumazi akonje. Cyane cyane mubidukikije byubushyuhe buke, HPMC irashobora gushonga vuba kandi igakora igisubizo kimwe.

3. Gukoresha byumwihariko tekinoroji yubushyuhe bwo hejuru mubikorwa bya HPMC

Icyiciro cya reaction

Mugukora reaction ya etherification ku bushyuhe bwo hejuru bwa 80-100 ° C, reaction yo gusimbuza hydroxypropyl na methyl irashobora kwihuta, kugirango HPMC ifite urwego rwo hejuru rwo gusimbuza no gutuza neza.

Kuma no kumenagura icyiciro

Ikoranabuhanga rishushe ryumuyaga hejuru ya 120 ° C ntirishobora gukuraho gusa ubuhehere, ariko kandi birinda ifu ya HPMC guhurira mugihe cyo kumisha. Ibikurikiraho, tekinoroji yo hejuru yo guhonyora ikoreshwa kugirango ifu ya pome ya HPMC irusheho kuba nziza kandi imwe, kandi ikwirakwizwa ryibicuruzwa riratera imbere.

Ubushyuhe bwo hejuru bukiza

Iyo HPMC ikoreshwa mubikoresho byo kubaka cyangwa gutwikira, kuvura ubushyuhe bwo hejuru birashobora kunoza uburyo bwo guhangana n’ibisebe, kurwanya sag no gufata neza amazi, bigatuma ibikorwa byubaka byubaka ahantu habi.

4. Ibyiza bya tekinoroji yubushyuhe bwo hejuru murwego rwa porogaramu ya HPMC

Ibikoresho byo kubaka

Mu gihe cy'ubushyuhe bwo hejuru, HPMC yerekana umubyimba mwiza no kubika amazi muri minisiteri na poro ya putty, birinda minisiteri kubura umwuma no guturika.

Inganda

HPMC ikomatanyirizwa nubushyuhe bwo hejuru ifite uburyo bwiza bwo kuringaniza no kurwanya kugabanuka mu irangi rya latex, biteza imbere gukomera no kwambara kwifata.

Inganda zimiti

Ikoranabuhanga ry’ubushyuhe bwo hejuru rirashobora kunoza uburinganire bwa HPMC mu gutwikira ibiyobyabwenge kandi bikagira ingaruka nziza ku biyobyabwenge.

Ikoreshwa ryubushyuhe bwo hejuru bwahydroxypropyl methylcellulosentabwo bizamura umusaruro gusa, ahubwo binatezimbere imikorere yibicuruzwa. Binyuze mu bushyuhe bwo hejuru, ubukonje, gushonga hamwe nubushyuhe bwa HPMC bwarushijeho kuba bwiza, bituma bugira ibyifuzo byinshi mubijyanye nubwubatsi, gutwikira hamwe nubuvuzi. Mu bihe biri imbere, hamwe no guhanga udushya twinshi mu ikoranabuhanga ry’ubushyuhe bwo hejuru, imikorere ya HPMC izarushaho kunozwa, itange umusanzu munini mu iterambere ry’ibikoresho bitangiza ibidukikije.