Niki pH ni HPMC ikemuka

Hydroxypropyl methylcellulose (HPMC)ni polymer ikoreshwa cyane muri farumasi, kwisiga, nibicuruzwa byibiribwa. Gukemura kwayo biterwa nibintu bitandukanye, harimo pH. Mubisanzwe, HPMC irashonga haba muburyo bwa acide na alkaline, ariko gukemura kwayo birashobora gutandukana ukurikije urugero rwo gusimbuza (DS) nuburemere bwa molekile (MW) ya polymer.

Mubihe bya acide, HPMC mubusanzwe igaragaza imbaraga nziza bitewe na protonation yitsinda ryayo ya hydroxyl, ikongerera imbaraga kandi ikwirakwizwa. Ubushobozi bwa HPMC bukunda kwiyongera uko pH igabanuka munsi ya pKa yayo, hafi ya 3.5-4.5 bitewe nurwego rwo gusimburwa.

Ibinyuranye, mubihe bya alkaline, HPMC irashobora kandi gukemuka, cyane cyane kubiciro bya pH. Kuri alkaline pH, deprotonation yitsinda rya hydroxyl ibaho, bigatuma habaho kwiyongera kwinshi binyuze muri hydrogène ihuza na molekile zamazi.

Ariko, ni ngombwa kumenya ko pH nyayo HPMC ihinduka ikemuka irashobora gutandukana ukurikije icyiciro cyihariye cya HPMC, urwego rwo gusimbuza, hamwe nuburemere bwa molekile. Mubisanzwe, amanota ya HPMC hamwe nimpamyabumenyi ihanitse yo gusimburwa hamwe nuburemere buke bwa molekuline yerekana gukemura neza kurwego rwo hasi rwa pH.

Mu miti ya farumasi,HPMCikoreshwa kenshi nka firime yambere, kubyimbye, cyangwa stabilisateur. Ibiranga imbaraga zayo ningirakamaro mugucunga imyirondoro irekura ibiyobyabwenge, ubwiza bwimikorere, hamwe no guhagarara kwa emulisiyo cyangwa guhagarikwa.

mugihe HPMC isanzwe ikemuka hejuru ya pH yagutse, imyitwarire yayo yo gukemura irashobora guhuzwa neza muguhindura pH yumuti no guhitamo icyiciro gikwiye cya HPMC hashingiwe kubisabwa.