Hydroxypropyl methylcellulose (HPMC)ni polymer itandukanye ikoreshwa munganda nka farumasi, ubwubatsi, kwisiga, ibiryo, no kwita kubantu. Ubukonje bwa HPMC bugira uruhare runini muguhitamo ibikwiye mubikorwa bitandukanye. Ubukonje buterwa n'uburemere bwa molekile, urugero rwo gusimburwa, hamwe no kwibanda. Gusobanukirwa amanota akwiye ya viscosity ningirakamaro muguhitamo neza HPMC kubikenewe byinganda.
Igipimo cya Viscosity
Ubukonje bwa AnxinCel®HPMC mubusanzwe bupimirwa mubisubizo byamazi ukoresheje viscometer izunguruka cyangwa capillary. Ubushyuhe busanzwe bwikigereranyo ni 20 ° C, kandi ubukonje bugaragarira mumasegonda ya milipasikali (mPa · s cyangwa cP, centipoise). Ibyiciro bitandukanye bya HPMC bifite viscosities zitandukanye bitewe nibisabwa.
Impamyabumenyi ya Viscosity hamwe nibisabwa
Imbonerahamwe ikurikira irerekana amanota rusange ya viscosity ya HPMC nibisabwa bijyanye:
| Icyiciro cya Viscosity (mPa · s) | Kwibanda bisanzwe (%) | Gusaba |
| 5 - 100 | 2 | Amaso atonyanga, inyongeramusaruro, guhagarikwa |
| 100 - 400 | 2 | Ibinini bya tableti, binders, ibifatika |
| 400 - 1.500 | 2 | Emulisiferi, amavuta, sisitemu yo gutanga ibiyobyabwenge |
| 1.500 - 4.000 | 2 | Ibikoresho byibyimbye, ibicuruzwa byita kumuntu |
| 4.000 - 15.000 | 2 | Ubwubatsi (amatafari ya tile, ibicuruzwa bishingiye kuri sima) |
| 15.000 - 75.000 | 2 | Kugenzura-kurekura ibiyobyabwenge, ibyubaka |
| 75.000 - 200.000 | 2 | Ibikoresho bifata neza cyane, gushimangira sima |
Ibintu bigira ingaruka kuri Viscosity
Ibintu byinshi bigira ingaruka kumyumvire ya HPMC:
Uburemere bwa molekile:Uburemere buke bwa molekuline butera kwiyongera kwijimye.
Impamyabumenyi yo gusimburwa:Ikigereranyo cya hydroxypropyl na methyl matsinda bigira ingaruka no gukomera.
Kwibanda ku gisubizo:Kwibanda cyane bivamo ubwiza bwinshi.
Ubushyuhe:Ubushuhe bugabanuka hamwe n'ubushyuhe bwiyongera.
pH Ibyiyumvo:Ibisubizo bya HPMC birahagaze murwego rwa pH rwa 3-11 ariko birashobora gutesha agaciro hanze yuru rwego.
Igipimo cyogosha:HPMC yerekana ibintu bitari Newtonian itemba, bivuze ko ubukonje bugabanuka mugihe cyo guhangayika.
Gusaba-Ibitekerezo byihariye
Imiti:HPMC ikoreshwa mugutegura ibiyobyabwenge kugirango irekurwe igenzurwa kandi nka binder muri tableti. Impamyabumenyi yo hasi (100-400 mPa · s) ikundwa kubitwikiriye, mugihe amanota yo hejuru (15,000+ mPa · s) akoreshwa mugukomeza-kurekura.
Ubwubatsi:AnxinCel®HPMC ikora nk'umukozi wo kubika amazi no gufatira mu bicuruzwa bishingiye kuri sima. Amanota yo hejuru cyane (hejuru ya 4000 mPa · s) nibyiza kunoza imikorere no guhuza imbaraga.
Amavuta yo kwisiga no kwita ku muntu:Muri shampo, amavuta yo kwisiga, hamwe na cream, HPMC ikora nkibyimbye na stabilisateur. Urwego rwo hagati rwijimye (400-1,500 mPa · s) rutanga uburinganire bwiza hagati yimiterere yimiterere.
Inganda zikora ibiribwa:Nkongeramo ibiryo (E464), HPMC yongerera ubwiza, ituze, hamwe nubushuhe. Impamyabumenyi yo hasi (5-100 mPa · s) ituma ikwirakwizwa neza nta kubyimba cyane.
GuhitamoHPMCUrwego rwa viscosity rushingiye kubigenewe gukoreshwa, hamwe n amanota yo hasi ya viscosity akwiranye nibisubizo bisaba umubyimba muto cyane hamwe n amanota yo hejuru ya viscosity akoreshwa muburyo bukenera ibintu bifatika kandi bihamye. Kugenzura neza ubukonje butuma imikorere ikora imiti, ubwubatsi, ibiryo, n’amavuta yo kwisiga. Gusobanukirwa nibintu bigira ingaruka ku bwiza bifasha mugutezimbere ikoreshwa rya HPMC mubikorwa bitandukanye byinganda.
Igihe cyo kohereza: Gashyantare-11-2025