Hydroxypropyl methylcellulose (HPMC)bụ ihe polymer soluble mmiri nke a na-ejikarị eme ihe na ọgwụ, ihe owuwu, nri, ihe ịchọ mma na mpaghara ndị ọzọ. Ngwongwo viscosity ya bụ ihe dị mkpa iji tụọ omume rheological ya n'okpuru gburugburu dị iche iche. Ịghọta viscosity onwunwe nke HPMC aqueous ngwọta na-enyere anyị aka ịghọta nke ọma omume na ọrụ dị iche iche ngwa.
1. Chemical Ọdịdị na Njirimara nke HPMC
A na-enweta HPMC site na mgbanwe kemịkalụ nke cellulose eke, tumadi sitere na hydroxypropylation na methylation nke mkpụrụ ndụ cellulose. Na usoro kemịkalụ nke HPMC, iwebata methyl (-OCH₃) na hydroxypropyl (-OCH₂ CHOHCH₃) dị iche iche na-eme ka ọ bụrụ mmiri soluble ma nwee ikike mgbanwe viscosity dị mma. Arụ ọrụ viscosity nke ngwọta mmiri ya na mkpokọta dị iche iche na okpomọkụ na-emetụta ọtụtụ ihe dị ka ịdị arọ molecular, ogo nke nnọchi, ntinye ngwọta, wdg.
2. Mmekọrịta dị n'etiti viscosity na itinye uche
Viscosity nke AnxinCel®HPMC aqueous ngwọta na-abawanye na-abawanye na itinye uche. Nke a bụ n'ihi na n'ọtụtụ dị elu, mmekọrịta dị n'etiti ụmụ irighiri ihe na-eme ka ọ dịkwuo elu, na-eme ka mmụba na-eguzogide mmiri. Otú ọ dị, solubility na viscosity e ji mara HPMC na mmiri na-emetụtakwa molekụla arọ. HPMC nwere ibu molekụla dị elu na-egosipụtakarị viscosity dị elu, ebe ịdị arọ molekụla dị obere dị obere.
N'ebe dị ala: ngwọta HPMC na-egosipụta viscosity dị ala na ntinye uche dị ala (dị ka n'okpuru 0.5%). N'oge a, mmekọrịta dị n'etiti ụmụ irighiri ihe na-adịghị ike na mmiri mmiri dị mma. A na-ejikarị ya na ngwa dị ka mkpuchi na ntọhapụ ọgwụ.
N'ebe dị elu: N'ebe dị elu (dị ka 2% ma ọ bụ karịa), viscosity nke HPMC aqueous solution na-abawanye nke ọma, na-egosi ihe onwunwe yiri ngwọta colloidal. N'oge a, mmiri mmiri nke ngwọta ahụ na-enwekwu nguzogide.
3. Mmekọrịta n'etiti viscosity na okpomọkụ
The viscosity nke HPMC aqueous ngwọta bụ nnọọ mmetụta okpomọkụ. Ka okpomọkụ na-abawanye, mmegharị n'etiti ụmụ irighiri mmiri na-abawanye, na mmekọrịta dị n'etiti ụmụ irighiri ihe HPMC na-esiwanye ike, na-ebute mbelata nke viscosity. Nke a na njirimara na-eme ka ngwa nke HPMC na dị iche iche okpomọkụ na-egosi ike adjustability. Dịka ọmụmaatụ, n'okpuru ọnọdụ okpomọkụ dị elu, viscosity nke HPMC na-ebelatakarị, nke dị mkpa karịsịa na usoro ọgwụ, karịsịa n'ụdị usoro ntọhapụ nke ọgwụ, ebe mgbanwe okpomọkụ nwere ike imetụta nkwụsi ike na mmetụta nke ngwọta.
4. Mmetụta nke pH na viscosity
Enwere ike imetụta viscosity nke ngwọta mmiri HPMC site na uru pH nke ngwọta ahụ. Ọ bụ ezie na HPMC bụ ihe na-abụghị ionic, hydrophilicity ya na viscosity Njirimara na-emetụta tumadi site molekụla Ọdịdị na ngwọta gburugburu ebe obibi. Otú ọ dị, n'okpuru oke acidic ma ọ bụ alkaline ọnọdụ, solubility na molekụla Ọdịdị nke HPMC nwere ike ịgbanwe, si otú na-emetụta viscosity. Dịka ọmụmaatụ, n'okpuru ọnọdụ acidic, solubility nke HPMC nwere ike ịdalata ntakịrị, na-eme ka viscosity dịkwuo elu; mgbe n'okpuru ọnọdụ alkaline, hydrolysis nke ụfọdụ HPMC nwere ike ime ka ịdị arọ ya belata, si otú ahụ belata viscosity ya.
5. Arọ Molecular na viscosity
Mkpụrụ ndụ arọ bụ otu n'ime ihe ndị dị mkpa na-emetụta viscosity nke HPMC aqueous ngwọta. Ibu arọ dị elu na-abawanye njikọ na njikọ n'etiti ụmụ irighiri ihe, na-ebute mmụba viscosity. AnxinCel®HPMC dị obere molekul nwere ike solubility ka mma na mmiri yana viscosity dị ala. Ngwa dị iche iche chọrọ na-achọkarị nhọrọ nke HPMC nwere nha molekụla dị iche iche. Dịka ọmụmaatụ, na mkpuchi na adhesives, a na-ahọrọ HPMC dị arọ dị elu maka mma mmachi na fluidity; mgbe a na-eji ọgwụ eme ihe, enwere ike iji HPMC dị obere molekul iji chịkwaa ọnụego ntọhapụ nke ọgwụ.
6. Mmekọrịta dị n'etiti ọnụ ọgụgụ shear na viscosity
The viscosity nke HPMC aqueous ngwọta na-emekarị na-agbanwe na shiee ọnụego, na-egosi na-ahụkarị pseudoplastic rheological omume. Mmiri pseudoplastic bụ mmiri nke viscosity ya ji nwayọọ nwayọọ na-ebelata site n'ịbawanye ọnụ ọgụgụ shear. Njirimara a na-enyere ngwọta HPMC aka ịnọgide na-enwe viscosity dị elu na ọnụ ọgụgụ shear dị ala mgbe etinyere ya, ma kwalite mmụba na ọnụ ọgụgụ dị elu. Dịka ọmụmaatụ, na ụlọ ọrụ mkpuchi, HPMC ngwọta na-achọkarị igosi viscosity dị elu na ọnụ ọgụgụ dị ala mgbe a na-etinye ya iji hụ na adhesion na ọkwa nke mkpuchi ahụ, ebe n'oge a na-ewu ụlọ, ọ dị mkpa iji mee ka ọnụ ọgụgụ dị elu dịkwuo elu iji mee ka ọ dịkwuo mma.
7. Ngwa na njirimara viscosity nke HPMC
The viscosity e ji maraHPMCmee ka a na-eji ya eme ihe n'ọtụtụ ebe. Dịka ọmụmaatụ, na ụlọ ọrụ na-emepụta ọgwụ, a na-ejikarị HPMC eme ihe dị ka onye na-emepụta ọgwụ na-akwado ya, a na-ejikwa ụkpụrụ viscosity ya chịkwaa ọnụego ntọhapụ nke ọgwụ ahụ; na-ewu ụlọ ọrụ, HPMC na-eji dị ka a thickener ka mma workability na fluidity nke ngwa agha na adhesives; N'ime ụlọ ọrụ nri, enwere ike iji HPMC dị ka thickener, emulsifier na stabilizer iji meziwanye uto na ọdịdị nke nri.
Njirimara viscosity nke AnxinCel®HPMC aqueous solution bụ isi ihe na ntinye ya na mpaghara dị iche iche. Ịghọta mmekọrịta ya na ihe ndị dị ka itinye uche, okpomọkụ, pH, molecular weight na shear rate bụ ihe dị oke mkpa maka ịkwalite arụmọrụ ngwaahịa na ịkwalite mmetụta ngwa.
Oge nzipu: Jan-27-2025