Hydroxypropyl methylcellulose (HPMC)bụ polymer soluble mmiri nke amịpụtara site na mkpụrụ ndụ cellulose na-emezi kemịkal. Ọ na-ejikọta ihe ndị sitere n'okike nke cellulose na arụ ọrụ gbanwetụrụ, nwere ezigbo mmiri solubility, ngbanwe viscosity na ihe ndị na-emepụta ihe nkiri, a na-ejikwa ya na nkà mmụta ọgwụ, ihe ịchọ mma, ihe owuwu, nri na ubi ndị ọzọ. Mkparịta ụka ma ọ bụ ihe mgbaze kwesịrị n'ezie ịmata ọdịiche dị na ngwa ya na akụrụngwa dị iche iche.
Ọdịdị kemịkalụ na Njirimara nke hydroxypropyl methylcellulose
A na-akwado HPMC site na iwebata otu abụọ nnọchi, hydroxypropyl (–CH2CH(OH)CH3) na methyl (–CH3), n'ime nkeji glucose nke molekul cellulose. Mkpụrụ ndụ cellulose n'onwe ya bụ polysaccharide nwere ogologo agbụ nke ọtụtụ sel β-D-glucose jikọtara ya na njikọ β-1,4-glycosidic, na otu hydroxyl ya (OH) nwere ike dochie ya site na otu kemịkalụ dị iche iche, nke na-eme ka ihe onwunwe ya dịkwuo mma.
N'oge usoro nhazi, methylation na-eme ka mkpụrụ ndụ cellulose dịkwuo lipophilic, ebe hydroxypropylation na-eme ka mmiri ya dịkwuo mma. Site na mgbanwe abụọ a, HPMC na-aghọ ngwakọta polymer na-agbanwe agbanwe nke enwere ike igbari na mmiri.
Solubility na ọrụ nke HPMC
HPMC nwere ezigbo solubility na mmiri, ọkachasị na mmiri ọkụ. Ka okpomọkụ na-ebili, ọnụego mgbasa na solubility ga-abawanye. Agbanyeghị, HPMC n'onwe ya abụghị “ihe mgbaze” a na-ahụkarị, mana ejiri ya dị ka ihe mgbaze ma ọ bụ thickener. N'ime mmiri mmiri, ọ nwere ike ịmepụta ngwọta colloidal site na mmekọrịta ya na mkpụrụ ndụ mmiri, si otú ahụ na-edozi viscosity na rheology nke ngwọta.
Ọ bụ ezie na HPMC nwere ike ịgbaze na mmiri, ọ nweghị ihe eji eme "ihe mgbaze" n'echiche ọdịnala. Ihe mgbaze na-abụkarị mmiri mmiri nwere ike igbari ihe ndị ọzọ, dị ka mmiri, mmanya, ketones ma ọ bụ ihe mgbaze organic ndị ọzọ. Mgbasa nke HPMC n'onwe ya n'ime mmiri bụ ihe na-arụ ọrụ maka mkpụkọ, gelling na nhazi ihe nkiri.
Ngalaba ngwa nke HPMC
Medical ubi: HPMC na-ejikarị dị ka ihe excipient maka ọgwụ ọjọọ eme ihe, karịsịa na nkwadebe nke ọnụ siri ike onunu ogwu ụdị (dị ka mbadamba na capsules), tumadi na-eji maka ndim, adhesion, gelling, film-akpụ na ndị ọzọ ọrụ. Ọ nwere ike melite bioavailability nke ọgwụ ọjọọ ma na-ejikwa ya na nkwado nkwado na-adịgide adịgide iji nyere aka ịchịkwa ntọhapụ nke ọgwụ.
Ogige ịchọ mma: A na-eji HPMC eme ihe na ngwaahịa nlekọta anụ ahụ, ncha ntutu, ihe mkpuchi ntutu, ude anya na ihe ịchọ mma ndị ọzọ dị ka onye na-agbapụta, stabilizer na onye na-emepụta ihe nkiri. Ọrụ ya na ihe ịchọ mma bụ tumadi iji mee ka nkwụsi ike na ọdịdị nke ngwaahịa ahụ dịkwuo elu ma mee ka ọ dịkwuo mma.
Ogige ihe owuwu: N'ime ụlọ ọrụ ihe owuwu, a na-eji HPMC eme ihe dị ka ihe na-agbasa na simenti, ngwa ngwa akọrọ, agba na ngwaahịa ndị ọzọ. Ọ nwere ike ịbawanye viscosity nke agba, melite arụmọrụ ihe owuwu ma gbasaa oge owuwu.
Ebe nri: A na-eji HPMC dị ka ihe mgbakwunye nri, nke a na-ejikarị eme ihe, emulsification na mma uto, a na-ahụkarị ya na nri ndị nwere obere abụba, candies na ice cream. Tụkwasị na nke ahụ, a pụkwara iji ya mee ka ọdịdị ahụ dịkwuo mma, uto na ịdị ọhụrụ nke nri.
Ngwa dị ka ihe mgbaze
N'ime usoro nkwadebe ụfọdụ akọwapụtara, HPMC nwekwara ike iji dị ka ihe inyeaka nke ihe mgbaze. Dịka ọmụmaatụ, na ụlọ ọrụ na-emepụta ọgwụ, solubility nke HPMC na-enyere ya aka iji dị ka diluent ma ọ bụ solubilizer na nkwadebe ọgwụ, karịsịa na ụfọdụ nkwadebe mmiri mmiri, ebe ọ nwere ike inye aka n'ụzọ dị irè igbari ọgwụ na-emepụta otu ngwọta edozi.
N'ụfọdụ mkpuchi mmiri,HPMCA pụkwara iji ya mee ihe dị ka onye na-enye aka maka ihe mgbaze iji meziwanye ihe ndị rheological na arụ ọrụ nke mkpuchi, ọ bụ ezie na isi ihe mgbaze na mkpuchi na-abụkarị mmiri ma ọ bụ ihe mgbaze organic.
Ọ bụ ezie na HPMC nwere ike gbazere na mmiri n'ọtụtụ ngwa iji mepụta colloid ma ọ bụ ngwọta ma mee ka viscosity na fluidity nke ngwọta ya dịkwuo elu, a naghị ewere ya n'onwe ya dị ka ihe mgbaze n'echiche ọdịnala. Kama nke ahụ, a na-ejikarị ya eme ihe dị ka ihe na-arụ ọrụ dị ka ihe na-agba agba, onye na-emepụta gelling na onye na-emepụta ihe nkiri. Ọ nwere ngwa dị iche iche na mpaghara dị iche iche, ọkachasị na ụlọ ọrụ ọgwụ, ịchọ mma, nri, na ụlọ ọrụ ihe owuwu. Ya mere, mgbe ị na-aghọta ọrụ na ihe onwunwe nke HPMC, a ga-ewere ya dị ka polymer na-edozi mmiri na-arụ ọrụ dị iche iche karịa ihe mgbaze dị mfe.
Oge nzipu: Mar-21-2025