Hydroxypropyl methylcellulose (HPMC) bụ ihe na-abụghị ionic mmiri-soluble polymer compound nwetara site kemịkalụ mgbanwe nke eke cellulose. A na-eji ya n'ọtụtụ ebe na nri, ọgwụ, ịchọ mma na ụlọ ọrụ ihe owuwu, ọkachasị dị ka nrapado, thickener, emulsifier na onye nkwusioru na nkwadebe ọgwụ. N'ime usoro ngwa ahụ, njirimara viscosity nke ngwọta mmiri mmiri HPMC dị oke mkpa maka ịrụ ọrụ ya na mpaghara dị iche iche.
1. Ọdịdị na Njirimara nke hydroxypropyl methylcellulose
Ọdịdị molekụla nke HPMC nwere otu abụọ nọchiri anya ya, hydroxypropyl (-CH₂CHỌCH₃) na methyl (-OCH₃), nke na-eme ka ọ nwee ezigbo mmiri solubility na ike mgbanwe. The HPMC molekul yinye nwere ụfọdụ isiike Ọdịdị, ma ọ nwekwara ike na-etolite a atọ akụkụ netwọk Ọdịdị na aqueous ngwọta, na-akpata na-abawanye na viscosity. Ibu molekụla ya, ụdị nnọchi na ogo ngbanwe (ya bụ, ogo hydroxypropyl na nnọchi methyl nke otu ọ bụla) nwere mmetụta dị mkpa na viscosity nke ngwọta.
2. Viscosity e ji mara nke aqueous ngwọta
The viscosity e ji mara nke HPMC aqueous ngwọta na-metụtara chiri anya ihe ndị dị ka ịta, molekụla arọ, okpomọkụ na pH uru nke mgbaze. N'ozuzu, viscosity nke HPMC aqueous ngwọta na-abawanye na mmụba nke itinye uche ya. Viscosity ya na-egosi omume rheological na-abụghị nke Newtonian, ya bụ, ka ọnụ ọgụgụ nke shear na-abawanye, viscosity nke ngwọta na-eji nwayọọ nwayọọ na-ebelata, na-egosi ihe na-egbuke egbuke.
(1) Mmetụta nke itinye uche
E nwere ụfọdụ mmekọrịta n'etiti viscosity nke HPMC aqueous ngwọta na ya ịta. Ka ntinye nke HPMC na-abawanye, a na-eme ka mmekọrịta molekụla dị na ngwọta mmiri na-eme ka ọ dịkwuo mma, na ntinye na njikọ njikọ nke ụdọ molecular na-abawanye, na-eme ka mmụba na viscosity nke ngwọta. Na obere mkpokọta, viscosity nke HPMC aqueous ngwọta na-abawanye linearly na-abawanye nke ịta, ma na elu ịta, na viscosity ibu nke ngwọta na-emekarị na-adị larịị na rute a kwụsiri ike uru.
(2) Mmetụta ịdị arọ molekụla
The molekụla arọ nke HPMC ozugbo na-emetụta viscosity nke ya aqueous ngwọta. HPMC na elu molekul arọ nwere ogologo molekụla agbụ na nwere ike na-etolite a ọzọ mgbagwoju anya netwọk Ọdịdị na aqueous ngwọta, dapụtara elu viscosity. N'ụzọ dị iche, HPMC nwere obere molekụla arọ nwere a looser netwọk Ọdịdị na ala viscosity ruru ya mkpumkpu molekụla agbụ. Ya mere, mgbe itinye n'ọrụ, ọ dị ezigbo mkpa ịhọrọ HPMC na a adabara molekụla arọ iji nweta ezigbo viscosity mmetụta.
(3) Mmetụta okpomọkụ
Okpomọkụ bụ ihe dị mkpa na-emetụta viscosity nke ngwọta mmiri HPMC. Ka okpomọkụ na-abawanye, mmegharị nke mkpụrụ ndụ mmiri na-abawanye na viscosity nke ngwọta na-ebelatakarị. Nke a bụ n'ihi na mgbe okpomọkụ ebili, nnwere onwe nke HPMC molecular yinye na-abawanye na mmekọrịta n'etiti ụmụ irighiri ihe na-ada mbà, si otú ibelata viscosity nke ngwọta. Agbanyeghị, nzaghachi nke HPMC sitere na batches ma ọ bụ ụdị dị iche iche na ọnọdụ okpomọkụ nwekwara ike ịdịgasị iche, yabụ ọnọdụ ọnọdụ okpomọkụ kwesịrị ka edozi ya dịka ngwa chọrọ.
(4) Mmetụta nke uru pH
HPMC n'onwe ya bụ ihe na-abụghị ionic, na viscosity nke ngwọta mmiri ya na-enwe mmetụta maka mgbanwe na pH. Ọ bụ ezie na HPMC na-egosipụta njirimara viscosity dịtụ kwụsiri ike na gburugburu acidic ma ọ bụ na-anọpụ iche, a ga-emetụta solubility na viscosity nke HPMC na gburugburu acidic ma ọ bụ alkaline. Dịka ọmụmaatụ, n'okpuru acid siri ike ma ọ bụ ọnọdụ alkaline siri ike, ụmụ irighiri ihe HPMC nwere ike imebi akụkụ ụfọdụ, si otú a na-ebelata viscosity nke ngwọta mmiri ya.
3. Rheological analysis nke viscosity e ji mara nke HPMC aqueous ngwọta
The rheological omume nke HPMC aqueous ngwọta na-emekarị na-egosi na-abụghị Newtonian mmiri e ji mara, nke pụtara na ya viscosity na-abụghị nanị metụtara ihe ndị dị otú ahụ dị ka ngwọta itinye uche na molekụla arọ, kamakwa ka shiee ọnụego. N'ikwu okwu n'ozuzu, na ọnụ ọgụgụ dị ala, ngwọta mmiri HPMC na-egosi viscosity dị elu, ebe ka ọnụ ọgụgụ nke shear na-abawanye, viscosity na-ebelata. A na-akpọ omume a "shear thinning" ma ọ bụ "shear thinning" ma dị ezigbo mkpa n'ọtụtụ ngwa bara uru. Dịka ọmụmaatụ, na mpaghara mkpuchi, nkwadebe ọgwụ, nhazi ihe oriri, wdg, àgwà ndị na-edozi ahụ nke HPMC nwere ike hụ na a na-edobe viscosity dị elu n'oge ngwa ngwa ngwa ngwa, ọ nwere ike na-asọba ngwa ngwa n'okpuru ọnọdụ dị elu.
4. Ihe ndị ọzọ na-emetụta viscosity nke HPMC aqueous ngwọta
(1) Mmetụta nke nnu
Mgbakwunye nke nnu solutes (dị ka sodium chloride) nwere ike ime ka viscosity nke HPMC aqueous ngwọta. Nke a bụ n'ihi na nnu nwere ike ịkwalite mmekọrịta dị n'etiti ụmụ irighiri ihe site n'ịgbanwe ike ionic nke ngwọta, nke mere na ụmụ irighiri ihe HPMC na-etolite nhazi netwọk ọzọ, si otú ahụ na-amụba viscosity. Agbanyeghị, mmetụta nke ụdị nnu na itinye uche na viscosity dịkwa mkpa ka edozi ya dabere n'ọnọdụ ụfọdụ.
(2) Mmetụta nke mgbakwunye ndị ọzọ
Ịtinye mgbakwunye ndị ọzọ (dịka surfactants, polymers, wdg) na ngwọta mmiri HPMC ga-emetụtakwa viscosity. Ọmụmaatụ, surfactants nwere ike ibelata viscosity nke HPMC, karịsịa mgbe surfactant ịta dị elu. Na mgbakwunye, ụfọdụ polymers ma ọ bụ ahụ nwekwara ike imekọrịta na HPMC ma gbanwee njirimara rheological nke ngwọta ya.
The viscosity e ji marahydroxypropyl methylcellulose aqueous ngwọta na-emetụta ọtụtụ ihe, gụnyere ịta, molekụla arọ, okpomọkụ, pH uru, wdg HPMC aqueous ngwọta na-emekarị exhibits na-abụghị Newtonian rheological Njirimara, nwere ezi ndim na shiee thinning Njirimara, na ọtụtụ-eji dị iche iche ulo oru na ọgwụ ubi. Ịghọta na ịmụta njirimara viscosity ndị a ga-enyere aka ịkwalite ojiji nke HPMC na ngwa dị iche iche. N'ime ngwa bara uru, a ga-ahọrọ ụdị HPMC kwesịrị ekwesị na ọnọdụ usoro dịka mkpa dị iche iche si nweta ezigbo viscosity na akụrụngwa rheological.
Oge nzipu: Mar-01-2025