Hydroxypropyl Methylcellulose (HPMC)bụ polymer soluble mmiri nke a na-ejikarị na ụlọ ọrụ ọgwụ, ịchọ mma na nri. N'ihi na ya magburu onwe mmiri solubility na viscosity mgbanwe Njirimara, HPMC na-ọtụtụ ebe na-eji na gels, ọgwụ na-achịkwa ntọhapụ dose ụdị, suspensions, thickeners na ndị ọzọ ubi. Ụdị dị iche iche na nkọwapụta nke HPMC nwere oke okpomọkụ dị iche iche, karịsịa mgbe ị na-akwadebe gels HPMC, okpomọkụ nwere mmetụta dị mkpa na solubility, viscosity na nkwụsi ike.
Mgbasa HPMC na nguzobe jel okpomọkụ nso
Okpomọkụ mgbasa
A na-agbaze HPMC n'ime mmiri na mmiri ọkụ, na nkwụsịtụ okpomọkụ na-adabere na ịdị arọ ya na ogo methylation na hydroxypropylation. N'ikwu okwu n'ozuzu, okpomọkụ mgbasa nke HPMC sitere na 70 ° C ruo 90 ° C, na nkọwa nke HPMC na-emetụta ọnọdụ okpomọkụ nke kpọmkwem. Dịka ọmụmaatụ, HPMC nwere obere viscosity na-agbaze na obere okpomọkụ (ihe dịka 70 Celsius C), ebe HPMC nwere viscosity dị elu nwere ike ịchọ ka okpomọkụ dị elu (nso 90 ° C) gbazee kpamkpam.
Okpomọkụ Nhazi Gel (okpomọkụ Gelation)
HPMC nwere ihe gel pụrụ iche na-agbanwe agbanwe, ya bụ, ọ ga-etolite gel n'ime oke okpomọkụ. The okpomọkụ nso nke HPMC gel na-tumadi emetụta ya molekụla arọ, chemical Ọdịdị, ngwọta ịta na ndị ọzọ nwekwara. N'ikwu okwu n'ozuzu, oke okpomọkụ nke HPMC gel na-abụkarị 35 ° C ruo 60 ° C. N'ime oke a, eriri molekụla HPMC ga-ahazigharị iji mepụta usoro netwọkụ nwere akụkụ atọ, na-eme ka ihe ngwọta gbanwee site na ọnọdụ mmiri mmiri gaa na steeti gel.
Enwere ike ikpebi ọnọdụ okpomọkụ nhazi gel kpọmkwem (ya bụ, okpomọkụ gelation). Okpomọkụ gelation nke HPMC gel na-adaberekarị n'ihe ndị a:
Ibu molekụla: HPMC nwere oke molekụla dị elu nwere ike ịmepụta gel na obere okpomọkụ.
Ngwọta Ngwọta: N'ihe dị elu nke ngwọta ngwọta, na-ebelata okpomọkụ nhazi gel na-abụkarị.
Ogo nke methylation na ogo nke hydroxypropylation: HPMC nwere ogo methylation dị elu na-etolitekarị gel na obere okpomọkụ n'ihi na methylation na-abawanye mmekọrịta n'etiti ụmụ irighiri ihe.
Mmetụta okpomọkụ
Na ngwa bara uru, okpomọkụ nwere mmetụta dị ukwuu na arụmọrụ na nkwụsi ike nke gel HPMC. Okpomọkụ dị elu na-abawanye ụbara nke ụdọ molekụla HPMC, si otú ahụ na-emetụta njiri ike na njirimara solubility nke gel. N'ụzọ megidere nke ahụ, obere okpomọkụ nwere ike imebi hydration nke HPMC gel ma mee ka usoro gel ghara ịdị n'otu. Na mgbakwunye, mgbanwe okpomọkụ nwekwara ike ime ka mmekọrịta dị n'etiti ụmụ irighiri ihe HPMC na mgbanwe na viscosity nke ngwọta.
Omume gelation HPMC na pH dị iche iche na ike ionic
Omume gelation nke HPMC na-emetụta ọ bụghị naanị site na okpomọkụ, kamakwa site na pH na ngwọta ionic ike. Dị ka ọmụmaatụ, solubility na gelation omume nke HPMC na dị iche iche pH ụkpụrụ ga-adị iche. Enwere ike ibelata solubility nke HPMC na gburugburu acidic, ebe enwere ike ịbawanye ike ya na gburugburu alkaline. N'otu aka ahụ, mmụba nke ike ionic (dị ka mgbakwunye nke nnu) ga-emetụta mmekọrịta dị n'etiti mkpụrụ ndụ HPMC, si otú ahụ gbanwee nhazi na nkwụsi ike nke gel.
Ngwa nke HPMC gel na njirimara okpomọkụ ya
Njirimara okpomọkụ nke HPMC gel na-eme ka a na-eji ya eme ihe na ntọhapụ ọgwụ, nkwadebe ịchọ mma na ubi ndị ọzọ:
Mwepụta ọgwụ a na-achịkwa
N'ime nkwadebe ọgwụ, a na-ejikarị HPMC eme ihe dị ka matriks ntọhapụ a na-achịkwa, a na-ejikwa njirimara gelation ya na-achịkwa ọnụego ntọhapụ nke ọgwụ. Site n'ịgbanwe nleba anya na okpomọkụ gelation nke HPMC, enwere ike ịchịkwa ntọhapụ nke ọgwụ ọjọọ. Mgbanwe okpomọkụ nke ọgwụ na tract gastrointestinal nwere ike ịkwalite ọzịza nke gel HPMC na mwepụta nke ọgwụ nke nta nke nta.
Ngwa ịchọ mma na ngwaahịa nlekọta onwe onye
A na-ejikarị HPMC eme ihe ịchọ mma dịka ude mmiri, gels, sprays ntutu na ude anụ ahụ. N'ihi mmetụta okpomọkụ ya, HPMC nwere ike ịhazigharị ọdịdị na nkwụsi ike nke ngwaahịa n'okpuru ọnọdụ okpomọkụ dị iche iche. Mgbanwe okpomọkụ na nhazi ihe ịchọ mma nwere mmetụta dị ukwuu na omume gelation nke HPMC, ya mere ọ dị mkpa ka e jiri nlezianya họrọ nkọwa HPMC kwesịrị ekwesị mgbe ị na-emepụta ngwaahịa.
Ụlọ ọrụ nri
N'ime nri, a na-eji HPMC eme ihe dị ka ihe na-eku ume na emulsifier, karịsịa na nri na ihe ọṅụṅụ dị njikere iri. Njirimara nwere mmetụta okpomọkụ na-enyere HPMC aka ịgbanwe ọnọdụ anụ ahụ ya n'oge kpo oku ma ọ bụ jụrụ oyi, si otú ahụ na-emetụta uto na nhazi nke nri.
Njirimara okpomọkụ nkeHPMCgels bụ isi ihe na ngwa ha. Site n'ịgbanwe ọnọdụ okpomọkụ, ntinye uche, na mgbanwe kemịkalụ, njirimara nke HPMC gels, dị ka solubility, ike gel na nkwụsi ike, nwere ike ịchịkwa nke ọma. Okpomọkụ nhazi gel na-adịkarị n'etiti 35 ° C na 60 Celsius C, ebe okpomọkụ mgbasa ya na-abụkarị 70 ° C ruo 90 ° C. A na-eji HPMC eme ihe n'ọtụtụ ebe na ụlọ ọrụ ọgwụ, ịchọ mma, na ụlọ ọrụ nri n'ihi omume gelation ya pụrụ iche nke na-agbanwe agbanwe na mmetụta okpomọkụ.
Oge nzipu: Jan-16-2025