Hydroxypropyl methylcellulose gel okpomọkụ

Hydroxypropyl methylcellulose (HPMC)bụ polymer vasatail nke a na-ejikarị eme ihe n'ụdị ọgwụ, ngwaahịa nri, ihe ịchọ mma, na ngwa ụlọ ọrụ mmepụta ihe. A na-eji HPMC kpọrọ ihe maka ike ya ịmepụta gels, ihe nkiri, na mmiri-solubility ya. Otú ọ dị, okpomọkụ gelation nke HPMC nwere ike ịbụ ihe dị mkpa na arụmọrụ ya na arụmọrụ ya na ngwa dị iche iche. Okwu metụtara okpomoku dị ka gelation okpomọkụ, viscosity mgbanwe na omume solubility nwere ike imetụta arụmọrụ na nkwụsi ike nke ngwaahịa ikpeazụ.

Ịghọta Hydroxypropyl Methylcellulose (HPMC)

Hydroxypropyl methylcellulose bụ ihe sitere na cellulose ebe a na-eji hydroxypropyl na methyl dochie ụfọdụ n'ime otu hydroxyl nke cellulose. Mgbanwe a na-eme ka polymer solubility dị na mmiri dịkwuo mma ma na-enye njikwa mma nke gelation na viscosity Njirimara. Ọdịdị nke polymer na-enye ya ikike ịmepụta gels mgbe ọ na-edozi mmiri mmiri, na-eme ka ọ bụrụ ihe kachasị amasị ya na ụlọ ọrụ dị iche iche.

HPMC nwere ihe pụrụ iche: ọ na-enweta gelation na okpomọkụ dị iche iche mgbe agbazere na mmiri. Omume gelation nke HPMC na-emetụta ihe ndị dị ka ịdị arọ molekụla, ogo nke nnọchi (DS) nke hydroxypropyl na methyl, yana ntinye nke polymer na ngwọta.

Gelation okpomọkụ nke HPMC

Gelation okpomọkụ na-ezo aka na okpomọkụ nke HPMC na-enweta mgbanwe nke oge site na ọnọdụ mmiri mmiri gaa na steeti gel. Nke a bụ oke dị oke mkpa n'ụdị dị iche iche, ọkachasị maka ngwaahịa ọgwụ na ịchọ mma ebe achọrọ nkwekọ na udidi.

Omume gelation nke HPMC na-ejikarị okpomọkụ gelation dị oke egwu (CGT). Mgbe ihe ngwọta ahụ na-ekpo ọkụ, polymer na-enweta mmekọrịta hydrophobic nke na-eme ka ọ gbakọta ma mepụta gel. Otú ọ dị, ọnọdụ okpomọkụ nke nke a na-eme nwere ike ịdịgasị iche dabere n'ọtụtụ ihe:

Ibu molekụla: Higher molekul arọ HPMC na-etolite gels na elu okpomọkụ. N'aka nke ọzọ, HPMC dị arọ molekul na-etolitekarị gels na obere okpomọkụ.

Ogo nke nnọchi (DS): Ogo nke nnọchi nke hydroxypropyl na methyl otu nwere ike imetụta solubility na gelation okpomọkụ. Ọkwa dị elu nke nnọchi (ọtụtụ methyl ma ọ bụ hydroxypropyl) na-agbadata okpomoku gelation, na-eme ka polymer dịkwuo nro ma na-anabata mgbanwe okpomọkụ.

Ntinye uche: Ọnụ ọgụgụ dị elu nke HPMC na mmiri nwere ike belata okpomọkụ gelation, dị ka ụbara ọdịnaya polymer na-eme ka mmekọrịta dịkwuo n'etiti ụdọ polymer, na-akwalite nhazi gel na obere okpomọkụ.

Ọnụnọ nke ions: Na ngwọta mmiri, ion nwere ike imetụta omume gelation nke HPMC. Ọnụnọ nke nnu ma ọ bụ electrolytes ndị ọzọ nwere ike gbanwee mmekọrịta nke polymer na mmiri, na-emetụta okpomọkụ gelation ya. Dịka ọmụmaatụ, mgbakwunye sodium chloride ma ọ bụ potassium salts nwere ike belata okpomọkụ gelation site na ibelata hydration nke ụdọ polymer.

pH: pH nke ngwọta nwekwara ike imetụta àgwà gelation. Ebe ọ bụ na HPMC na-anọpụ iche n'okpuru ọtụtụ ọnọdụ, pH mgbanwe na-enwekarị obere mmetụta, mana oke pH nwere ike ịkpata mmebi ma ọ bụ gbanwee àgwà gelation.

Nsogbu okpomọkụ na HPMC Gelation

Ọtụtụ okwu metụtara okpomọkụ nwere ike ime n'oge nhazi na nhazi nke gels dabeere na HPMC:

1. Gelation nke akaghi aka

Gelation na-akaghị aka na-eme mgbe polymer malitere gel na obere okpomọkụ karịa ka achọrọ, na-eme ka o sie ike ịhazi ma ọ bụ itinye n'ime ngwaahịa. Okwu a nwere ike ibili ma ọ bụrụ na okpomọkụ gelation dị nso na ọnọdụ okpomọkụ ma ọ bụ nhazi okpomọkụ.

Dịka ọmụmaatụ, na mmepụta nke gel ma ọ bụ ude ọgwụ, ọ bụrụ na ngwọta HPMC amalite gel n'oge ịgwakọta ma ọ bụ na-ejuputa, ọ nwere ike ime ka mgbochi, ederede na-ekwekọghị ekwekọ, ma ọ bụ ihe siri ike na-achọghị. Nke a na-enwe nsogbu karịsịa n'ichepụta nnukwu ihe, ebe njikwa okpomọkụ dị mkpa.

2. Gelation na-ezughị ezu

N'aka nke ọzọ, gelation na-ezughị ezu na-eme mgbe polymer adịghị gel dị ka a tụrụ anya na okpomọkụ a chọrọ, na-ebute ngwaahịa na-agba ọsọ ma ọ bụ obere viscosity. Nke a nwere ike ime n'ihi nhazi ezighi ezi nke ngwọta polymer (dịka ntinye uche na-ezighi ezi ma ọ bụ HPMC molekul na-ekwesịghị ekwesị) ma ọ bụ njikwa okpomọkụ ezughị ezu n'oge nhazi. A na-ahụkarị gelation na-ezughị ezu mgbe ntinye polymer dị oke ala, ma ọ bụ ihe ngwọta adịghị erute okpomọkụ gelation achọrọ maka oge zuru ezu.

3. Enweghi ike ikpo ọkụ

Enweghi ike ikpo ọkụ na-ezo aka na ndakpọ ma ọ bụ mmebi nke HPMC n'okpuru ọnọdụ okpomọkụ dị elu. Ọ bụ ezie na HPMC kwụsiri ike, ikpughe ogologo oge na okpomọkụ dị elu nwere ike ime ka hydrolysis nke polymer, na-ebelata ibu molekụla ya na, n'ihi ya, ike gelation ya. Nbibi a na-ekpo ọkụ na-eduga na nhazi gel na-esighị ike na mgbanwe na njirimara anụ ahụ nke gel, dị ka viscosity dị ala.

4. Mgbanwe viscosity

Mgbanwe viscosity bụ ihe ịma aka ọzọ nwere ike ime na gels HPMC. Ọdịiche okpomọkụ n'oge nhazi ma ọ bụ nchekwa nwere ike ime ka mgbanwe dị na viscosity, na-eduga n'ịdị mma ngwaahịa na-ekwekọghị ekwekọ. Dịka ọmụmaatụ, mgbe echekwara ya na okpomọkụ dị elu, gel nwere ike ịdị gịrịgịrị ma ọ bụ buru oke ibu dabere na ọnọdụ okpomọkụ etinyere ya. Ịnọgide na-enwe okpomọkụ nhazi na-agbanwe agbanwe dị mkpa iji hụ na viscosity kwụsiri ike.

Tebụl: Mmetụta okpomọkụ na Njirimara HPMC Gelation

Ihe ngwọta iji dozie nsogbu ndị metụtara okpomọkụ

Iji belata nsogbu ndị metụtara okpomọkụ na usoro gel HPMC, enwere ike iji usoro ndị a:

Welie ịdị arọ molekụla na ogo nnọchi anya: Ịhọrọ ịdị arọ molekụla ziri ezi na ogo nke nnọchi maka ngwa a chọrọ nwere ike inye aka hụ na okpomọkụ gelation dị n'ime oke achọrọ. Enwere ike iji HPMC dị arọ molekul ma ọ bụrụ na achọrọ okpomọkụ gelation dị ala.

Nchịkọta njikwa: Ịgbanwe ntinye nke HPMC na ngwọta nwere ike inye aka ịchịkwa okpomọkụ gelation. Ọnụ ọgụgụ dị elu na-akwalite nhazi gel na obere okpomọkụ.

Iji Nhazi Ọkụ na-achịkwa: N'ichepụta, njikwa okpomọkụ ziri ezi dị mkpa iji gbochie gelation akabeghị aka ma ọ bụ ezughị ezu. Usoro nchịkwa okpomọkụ, dị ka tankị na-ekpo ọkụ na-ekpo ọkụ na usoro jụrụ oyi, nwere ike hụ na nsonaazụ na-agbanwe agbanwe.

Tinye stabilizers na ihe mgbaze: Mgbakwunye nke stabilizers ma ọ bụ co-solvents, dị ka glycerol ma ọ bụ polyols, nwere ike inyere aka melite thermal nkwụsi ike nke HPMC gels ma belata viscosity fluctuations.

Nyochaa pH na ike ionic: Ọ dị mkpa ijikwa pH na ike ionic nke ngwọta iji gbochie mgbanwe na-adịghị mma na omume gelation. Usoro nchekwa nwere ike inye aka idobe ọnọdụ kachasị mma maka nhazi gel.

Okwu metụtara okpomọkụ metụtaraHPMCgels dị oke mkpa iji lebara anya maka ịrụ ọrụ ngwaahịa kachasị mma, ma ọ bụ maka ọgwụ, ịchọ mma, ma ọ bụ ngwa nri. Ịghọta ihe ndị na-emetụta okpomọkụ gelation, dị ka ịdị arọ nke molekụla, ntinye uche, na ọnụnọ nke ion, dị oké mkpa maka ịmepụta usoro na mmepụta ihe na-aga nke ọma. Ijikwa ọnọdụ okpomọkụ nke ọma na usoro nhazi nwere ike inye aka belata nsogbu dị ka gelation akaghi aka, gelation na-ezughị ezu, na ngbanwe viscosity, na-ahụ nkwụsi ike na nrụpụta ngwaahịa sitere na HPMC.