Ngwakọta gel na-ekpo ọkụ na HPMC/HPS

Hydroxypropyl methylcellulose (HPMC)ihe nkiri nwere arụmọrụ magburu onwe ya, ma n'ihi na HPMC bụ gel na-ekpo ọkụ, viscosity na obere okpomọkụ dị ntakịrị, nke na-adịghị mma maka mkpuchi (ma ọ bụ ịkụnye) na ihicha na ala okpomọkụ iji kwadebe ihe nkiri oriri, na-eme ka arụ ọrụ nhazi adịghị mma; na mgbakwunye, ọnụ ahịa ya dị elu na-egbochi ngwa ya. Hydroxypropyl starch (HPS) bụ jel oyi dị ọnụ ala, mgbakwunye ya nwere ike ịbawanye viscosity nke HPMC na obere okpomọkụ, melite ọrụ nhazi nke HPMC, ma belata ọnụ ahịa mmepụta, n'ihu, otu hydrophilicity , nkeji glucose na otu hydroxypropyl niile na-enye aka melite ndakọrịta nke polymers abụọ a. Ya mere, a kwadebere usoro ngwakọta gel na-ekpo ọkụ na-ekpo ọkụ site na ịgwakọta HPS na HPMC, na mmetụta nke okpomọkụ na nhazi gel nke HPMC/HPS na-ekpo ọkụ na-ekpo ọkụ na-ekpo ọkụ ka a na-amụ n'usoro site na iji rheometer na obere akụkụ X-ray usoro mgbasa ozi. , jikọtara ya na mmetụta nke ọnọdụ ọgwụgwọ okpomọkụ na microstructure na ihe onwunwe nke usoro akpụkpọ ahụ, wee wuo njikọ dị n'etiti usoro gel nke ngwakọta usoro-membrane-membrane Njirimara n'okpuru ọnọdụ ọgwụgwọ okpomọkụ.

Nsonaazụ na-egosi na na elu okpomọkụ, gel na eluHPMCọdịnaya nwere modulus dị elu na omume siri ike dị ka ihe dị ịrịba ama, usoro nke onwe ya nke ndị na-ekesa gel dị ntakịrị, na nha nke mkpokọta gel ka ukwuu; n'obere okpomọkụ, ọdịnaya HPS Ihe nlele gel dị elu nwere modulus dị elu, omume siri ike a ma ama, yana ụdị ụdị nke ndị na-ekesa gel. Maka ihe atụ ndị nwere otu ngwakọta ngwakọta, modulus na mkpa omume siri ike na njupụta ụdị nke gels nke HPMC na-achị na oke okpomọkụ dị elu karịa nke HPS na-achị na obere okpomọkụ. The ihicha okpomọkụ nwere ike imetụta usoro gel nke usoro tupu ihicha, na mgbe ahụ na-emetụta crystalline Ọdịdị na amorphous Ọdịdị nke ihe nkiri, na n'ikpeazụ nwere mmetụta dị mkpa na n'ibu Njirimara nke ihe nkiri, na-eme ka tensile ike na modulus nke film akpọnwụwo na elu okpomọkụ. Dị elu karịa nkụ na obere okpomọkụ. Ọnụ ọgụgụ dị jụụ enweghị mmetụta doro anya na nhazi kristal nke usoro ahụ, mana ọ na-enwe mmetụta na njupụta nke microdomain nke onwe ya yiri ihe nkiri ahụ. N'ime usoro a, njupụta nke ọdịdị yiri onwe nke ihe nkiri ahụ nwere ike imetụta ihe eji arụ ọrụ nke ihe nkiri ahụ. Arụmọrụ nwere nnukwu mmetụta.

Dabere na nkwadebe nke akpụkpọ ahụ agwakọtara, ọmụmụ ihe ahụ chọpụtara na iji ngwọta ayodiin na-ahọrọ ịcha akpụkpọ anụ HPMC/HPS jikọtara ọnụ guzobere usoro ọhụrụ maka ịhụ nke ọma nkesa nkesa na ngbanwe nke usoro ngwakọta n'okpuru microscope. usoro, nke nwere ụkpụrụ nduzi usoro maka ọmụmụ nke usoro nkesa nke usoro ngwakọta nke starch. N'iji usoro nyocha ọhụrụ a, jikọtara ya na infrared spectroscopy, nyocha nke microscopy electron na extensometer, a na-enyocha mgbanwe nke usoro, ndakọrịta na ihe ndị na-arụ ọrụ nke usoro ahụ ma mụọ ya, na-arụkọ ọrụ, mgbanwe oge na ọdịdị ihe nkiri. mmekọrịta dị n'etiti arụmọrụ. Nsonaazụ nyocha nke microscope na-egosi na usoro ahụ na-enweta mgbanwe nke oge mgbe oke HPS dị 50%, na ihe ngwakọta interphase dị na fim ahụ, na-egosi na sistemụ nwere ogo ndakọrịta; infrared, nyocha thermogravimetric na nsonaazụ SEM na-enyochakwa ngwakọta ahụ. Usoro nwere ụfọdụ ogo ndakọrịta. Modul nke ihe nkiri agwakọtara na-agbanwe mgbe ọdịnaya HPS bụ 50%. MgbeHPSọdịnaya dị elu karịa 50%, akụkụ kọntaktị nke ihe ngwakọta nke ngwakọta na-esi n'ahịrị kwụ ọtọ na-ejikọta akụkụ kọntaktị nke ihe atụ dị ọcha, na mgbe ọ na-erughị 50%, ọ na-apụ n'ụzọ na-adịghị mma site na nke a kwụ ọtọ. , bụ nke a na-ebutekarị site na ntụgharị usoro.