Hydroxypropyl methylcellulosebụ ụdị na-abụghị ionic cellulose agwakọta ether. N'adịghị ka ionic methyl carboxymethyl cellulose agwakọta ether, ọ dịghị emeghachi omume na arọ ọla. N'ihi ọnụ ọgụgụ dị iche iche nke methoxyl ọdịnaya na hydroxypropyl ọdịnaya na hydroxypropyl methylcellulose na dị iche iche viscosities, e nwere ọtụtụ iche na dị iche iche Njirimara, ihe atụ, elu methoxyl ọdịnaya na ala hydroxypropyl ọdịnaya Ya arụmọrụ dị nso na nke methyl cellulose, mgbe arụmọrụ nke ala methoxyl ọdịnaya na elu hydroxypropyl ọdịnaya nke cellulose. Otú ọ dị, na nke ọ bụla dị iche iche, ọ bụ ezie na ọ bụ naanị obere hydroxypropyl otu ma ọ bụ obere methoxyl otu dị, e nwere nnukwu ọdịiche dị na solubility na organic solvents ma ọ bụ flocculation okpomọkụ na aqueous ngwọta.
(1) Njirimara solubility nke hydroxypropyl methylcellulose
① Solubility nke hydroxypropyl methylcellulose na mmiriHydroxypropyl methylcellulosebụ n'ezie a ụdị methylcellulose gbanwetụrụ site propylene oxide (methoxy-propylene), ya mere, ọ ka nwere otu ihe onwunwe dị ka methyl cellulose nwere yiri àgwà nke mmiri oyi solubility na mmiri ọkụ insolubility. Otú ọ dị, n'ihi otu hydroxypropyl a gbanwere, okpomọkụ gelation ya na mmiri ọkụ dị elu karịa nke methyl cellulose. Dịka ọmụmaatụ, viscosity nke hydroxypropyl methylcellulose aqueous ngwọta na 2% methoxy ọdịnaya nnọchi ogo DS=0.73 na hydroxypropyl ọdịnaya MS=0.46 bụ 500mpa·s na 20°C, na gel okpomọkụ Ọ nwere ike iru nso 100°C, ebe methyl cellulose bụ naanị banyere 55C. N'ihe gbasara solubility ya na mmiri, a na-emeziwanye ya nke ọma. Dịka ọmụmaatụ, a na-azụta hydroxypropyl methylcellulose (granular udi 0.2 ~ 0.5mm na 20 ° C na viscosity 4% mmiri mmiri nke 2pa•s nwere ike zụta na okpomọkụ nke ụlọ, ọ na-adị mfe soluble na mmiri na-enweghị jụrụ oyi.
② Solubility nke hydroxypropyl methylcellulose na organic solvents solubility nke hydroxypropyl methylcellulose na organic solvents dịkwa mma karịa nke methylcellulose. Methylcellulose kwesịrị inwe akara ngbanwe methoxyl nke 2.1 ngwaahịa ndị dị n'elu, mana nwere hydroxypropyl MS = 1.5 ~ 1.8 na methoxy DS = 0.2 ~ 1.0, hydroxypropyl methylcellulose dị elu nke viscosity nwere ogo nke nnọchi n'elu 1.8 na-agbaze na mmiri mmiri na-ekpo ọkụ na mmiri na-ekpo ọkụ. solubility. Ọ na-agbaze na chlorinated hydrocarbons dị ka methylene chloride na chloroform, na organic mgbaze dị ka acetone, isopropanol na diacetone mmanya. Ya solubility na organic solvents dị mma karịa mmiri solubility.
(2) Ihe na-emetụta viscosity nke Hydroxypropyl Methyl Cellulose Nchọpụta viscosity ọkọlọtọ nke hydroxypropyl methyl cellulose bụ otu ihe ahụ dị ka nke ethers cellulose ndị ọzọ. A na-atụ ya na 20 Celsius na ngwọta mmiri 2% dị ka ọkọlọtọ. Viscosity nke otu ngwaahịa na-abawanye na mmụba nke itinye uche. Maka ngwaahịa ndị nwere nha molekụla dị iche iche n'otu ntinye uche, ngwaahịa ahụ nwere ibu arọ molekul nwere nnukwu viscosity. Mmekọrịta ya na okpomọkụ yiri nke methyl cellulose. Mgbe okpomọkụ na-ebili, viscosity na-amalite ịdaba, ma mgbe ọ ruru ụfọdụ okpomọkụ, viscosity na-ebili na mberede na gelation pụtara. Okpomọkụ gel nke ngwaahịa viscosity dị ala dị elu. dị elu. Ebe gel ya abụghị naanị ihe jikọrọ ya na viscosity nke ether, kamakwa ọ metụtara nhazi nke otu metoxyl na otu hydroxypropyl na ether na nha nke ogo nnọchi anya zuru oke. Ekwesiri ighota na hydroxypropyl methylcellulose bụkwa pseudoplastic, na ngwọta ya kwụsiri ike na ụlọ okpomọkụ na-enweghị mmebi ọ bụla nke viscosity ma e wezụga n'ihi na enwere ike imebi enzymatic.
(3) The nnu ndidi nke hydroxypropyl methylcellulose Ebe ọ bụ na hydroxypropyl methylcellulose bụ a na-abụghị ionic ether, ọ bụghị ionized na mmiri media, n'adịghị ka ndị ọzọ ionic cellulose ethers, dị ka carboxymethyl Base cellulose, na ngwọta na-emeghachi omume na arọ metal ion na precipitate. Nnu izugbe dị ka chloride, bromide, phosphate, nitrate, wdg agaghị amịpụta mgbe agbakwunyere ya na mmiri mmiri. Otú ọ dị, mgbakwunye nke nnu nwere mmetụta ụfọdụ na flocculation okpomọkụ nke mmiri mmiri ngwọta ya. Mgbe ntinye nnu na-abawanye, okpomọkụ gel na-ebelata. Mgbe ntinye nnu dị n'okpuru ebe flocculation, viscosity nke ngwọta na-eme ka ọ dịkwuo elu. Ya mere, a na-agbakwunye nnu ụfọdụ, n'ime ngwa, ọ nwere ike nweta mmetụta dị nro karịa n'ụzọ akụ na ụba. Ya mere, na ụfọdụ ngwa, ọ ka mma iji ngwakọta nke cellulose ether na nnu karịa ntinye elu nke ngwọta ether iji nweta mmetụta na-egbuke egbuke.
(4) Hydroxypropyl methylcellulose acid na alkali resistance Hydroxypropyl methylcellulose bụ n'ozuzu ike na acids na alkalis, na ọ dịghị emetụta na nso nke pH 2 ~ 12. Ọ nwere ike iguzogide ụfọdụ ihe ọkụ ọkụ, dị ka formic acid, acetic acid, citric acid, succinic acid, phosphoric acid, boric acid, wdg. Ma acid concentrated nwere mmetụta nke ibelata viscosity. Alkalis dị ka caustic soda, caustic potash na mmiri lime enweghị mmetụta na ya, mana ha nwere ike ịbawanye viscosity nke ngwọta ahụ ntakịrị, wee jiri nwayọọ nwayọọ belata ya.
(5) Enwere ike ịgwakọta ihe ngwọta nke hydroxypropyl methylcellulose Hydroxypropyl methylcellulose na ogige polymer mmiri na-agbaze ka ọ bụrụ ihe ngwọta edo na nke doro anya na viscosity dị elu. Ogige ndị a polymer gụnyere polyethylene glycol, polyvinyl acetate, polysilicon, polymethylvinyl siloxane, hydroxyethyl cellulose, na methyl cellulose. Ogige molekul dị elu dị ka chịngọm arabic, chịngọm igurube, karaya chịngọm, wdg nwekwara ezigbo ndakọrịta na ngwọta ya. Hydroxypropyl methylcellulose nwekwara ike jikọta ya na mannitol ester ma ọ bụ sorbitol ester nke stearic acid ma ọ bụ palmitic acid, ma nwee ike jikọta ya na glycerin, sorbitol na mannitol, a pụkwara iji ogige ndị a mee ihe dị ka hydroxypropyl methylcellulose Plasticizer maka cellulose.
(6) Mmiri na-adịghị aṅụ mmiricellulose ethersnke hydroxypropyl methylcellulose nwere ike ime njikọ n'elu ala na aldehydes, nke mere na ethers ndị a na-edozi mmiri na-agbanye na ngwọta ma ghọọ ihe na-adịghị ike na mmiri. Aldehydes nke na-eme ka hydroxypropyl methylcellulose insoluble gụnyere formaldehyde, glyoxal, succinic aldehyde, adipaldehyde, wdg Mgbe ị na-eji formaldehyde, a ga-akwụ ụgwọ nlebara anya pụrụ iche na uru pH nke ngwọta, n'etiti nke glioxal na-emeghachi omume, ya mere, a na-ejikarị glycoxal eme ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe na-emepụta ihe na-eme ka crosslinks. Usoro onunu ogwu nke ụdị onye na-ejikọta ọnụ na ngwọta bụ 0.2% ~ 10% nke oke ether, ọkacha mma 7% ~ 10%, dịka ọmụmaatụ, 3.3% ~ 6% nke glioxal bụ ihe kacha mma. N'ozuzu, ọgwụgwọ okpomọkụ bụ 0 ~ 30 ℃, na oge bụ 1 ~ 120min. A ghaghị ime mmeghachi omume na-agafe agafe n'okpuru ọnọdụ acidic. N'ozuzu, a na-edozi pH nke ngwọta na ihe dịka 2 ~ 6 site na ịgbakwunye acid siri ike ma ọ bụ organic carboxylic acid na ngwọta, ọkacha mma n'etiti 4 ~ 6, mgbe ahụ, a na-agbakwunye aldehydes iji mee mmeghachi omume crosslinking. Acid eji eme ihe nwere hydrochloric acid, sulfuric acid, phosphoric acid, formic acid, acetic acid, hydroxy-acetic acid, succinic acid ma ọ bụ citric acid wdg, ebe enwere ike iji formic acid ma ọ bụ acetic acid, yana formic acid kacha mma. A nwekwara ike ịgbakwunye acid na aldehyde n'otu oge iji mee ka ngwọta ahụ nweta mmeghachi omume na-ejikọta n'ime oke pH chọrọ. A na-ejikarị mmeghachi omume a eme ihe na usoro ọgwụgwọ ikpeazụ na usoro nkwadebe nke cellulose ethers. Mgbe ether cellulose na-adịghị ike, ọ dị mma iji.
20 ~ 25 ℃ mmiri maka ịsacha na ọcha. Mgbe a na-eji ngwaahịa ahụ eme ihe, enwere ike ịgbakwunye ihe ndị na-edozi ahụ na ngwọta nke ngwaahịa ahụ iji dozie pH nke ngwọta ahụ ka ọ bụrụ alkaline, ngwaahịa ahụ ga-agbaze na ngwọta ngwa ngwa. Usoro a na-emetụtakwa ọgwụgwọ nke ihe nkiri ahụ mgbe e mere ihe ngwọta cellulose ether ka ọ bụrụ ihe nkiri na-eme ka ọ bụrụ ihe nkiri na-adịghị edozi.
(7) The enzyme eguzogide hydroxypropyl methylcellulose bụ theoretically cellulose mmepụta, dị ka onye ọ bụla anhydroglucose otu, ma ọ bụrụ na e nwere a ike bonded substituent otu, ọ dịghị mfe na-ebute site microorganisms, ma n'ezie okokụre ngwaahịa Mgbe nnọchi uru karịa 1, ọ ga-abụkwa degraded site yinye nke ọ bụla n'ime enzymes pụtara na nke ọ bụla n'ime usoro enzymes nke edo edo na-abụghị nke otu n'ime ha. ezuru, na microorganisms nwere ike imebi na otu anhydroglucose na-edochighị anya na-etolite shuga, dị ka nri maka microorganisms na-amịkọrọ. Ya mere, ọ bụrụ na ogo nke etherification nnọchi nke cellulose na-abawanye, nguzogide enzymatic nke cellulose ether ga-abawanye. Dị ka akụkọ si kwuo, n'okpuru ọnọdụ a na-achịkwa, nsonaazụ hydrolysis nke enzymes mere, viscosity nke hydroxypropyl methylcellulose (DS=1.9) bụ 13.2%, methylcellulose (DS=1.83) bụ 7.3%, methylcellulose (DS=1.66) bụ 3.8% cell. Enwere ike ịhụ na hydroxypropyl methylcellulose nwere ikike mgbochi enzyme siri ike. Ya mere, a na-eji ihe mkpuchi dị mma nke enzyme hydroxypropyl methylcellulose, jikọtara ya na mgbasa ozi dị mma, nke na-emepụta ihe na ihe nkiri, na-eji mkpuchi mmiri-emulsion, wdg, na n'ozuzu ọ dịghị mkpa ịgbakwunye ihe nchekwa. Otú ọ dị, maka nchekwa ogologo oge nke ngwọta ma ọ bụ mmetọ nwere ike site n'èzí, a pụrụ ịgbakwunye ihe nchekwa dị ka ihe nchebe, na nhọrọ nwere ike ikpebi dịka ihe ikpeazụ chọrọ nke ngwọta ahụ. Phenylmercuric acetate na manganese fluorosilicate bụ ihe nchebe dị irè, ma ha niile nwere Nsi, a ghaghị ilebara anya na ọrụ ahụ. N'ozuzu, 1 ~ 5mg nke phenylmercury acetate nwere ike ịgbakwunye na ngwọta kwa liter nke usoro onunu ogwu.
(8) Arụmọrụ nkehydroxypropyl methylcelluloseihe nkiri Hydroxypropyl methylcellulose nwere ọmarịcha ihe na-emepụta ihe nkiri. A na-ekpuchi ihe ngwọta mmiri ya ma ọ bụ ihe ngwọta nke organic na efere iko, ọ na-aghọkwa enweghị agba na nghọta mgbe ihichachara. Na ihe nkiri siri ike. Ọ nwere ezigbo nguzogide mmiri ma na-anọgidesi ike na oke okpomọkụ. Ọ bụrụ na agbakwunyere plasticizer hygroscopic, elongation na mgbanwe ya nwere ike ịkwalite. N'ihe gbasara imeziwanye mgbanwe, plasticizers dị ka glycerin na sorbitol kacha mma. N'ozuzu, ihe ngwọta ngwọta bụ 2% ~ 3%, na ego nke plasticizer bụ 10% ~ 20% nke cellulose ether. Ọ bụrụ na ọdịnaya nke plasticizer dị oke elu, colloidal dehydration shrinkage ga-eme na oke iru mmiri. Ike ike nke ihe nkiri ahụ na plasticizer agbakwunyere dị ukwuu karịa nke na-enweghị plasticizer, ọ na-abawanye na mmụba nke ego agbakwunyere. N'ihe gbasara hygroscopicity nke ihe nkiri ahụ, ọ na-abawanye na ụba nke plasticizer.
Oge nzipu: Eprel-25-2024