Kedu ihe pH bụ HPMC soluble

Hydroxypropyl methylcellulose (HPMC)bụ polymer a na-ejikarị na ọgwụ, ihe ịchọ mma, na ngwaahịa nri. Solubility ya dabere na ihe dị iche iche, gụnyere pH. N'ozuzu, HPMC bụ soluble na ma acidic na alkaline ọnọdụ, ma ya solubility nwere ike ịdị iche iche dabere na ogo nke nnọchi (DS) na molekụla arọ (MW) nke polima.

N'ọnọdụ acidic, HPMC na-egosipụtakarị ezigbo solubility n'ihi protonation nke otu hydroxyl ya, nke na-eme ka hydration na dispersibility ya dịkwuo elu. Solubility nke HPMC na-agbasawanye ka pH na-ebelata n'okpuru pKa ya, nke dị gburugburu 3.5-4.5 dabere na ogo nke nnọchi.

N'aka nke ọzọ, na ọnọdụ alkaline, HPMC nwekwara ike soluble, karịsịa na ụkpụrụ pH dị elu. Na pH alkaline, mwepu nke otu hydroxyl na-eme, na-eduga n'ịbawanye solubility site na njikọ hydrogen na ụmụ irighiri mmiri.

Otú ọ dị, ọ dị mkpa iburu n'obi na kpọmkwem pH nke HPMC na-aghọ soluble nwere ike ịdịgasị iche dabere na kpọmkwem ọkwa nke HPMC, ogo nke nnọchi ya, na molekụla arọ ya. Na-emekarị, akara ule HPMC nwere ogo dị elu nke nnọchi na nha molekụla dị ala na-egosipụta ike dị mma na ụkpụrụ pH dị ala.

N'ụdị ọgwụ,HPMCna-ejikarị dị ka ihe nkiri mbụ, thickener, ma ọ bụ stabilizer. Njirimara solubility ya dị oke mkpa maka ịchịkwa profaịlụ ntọhapụ ọgwụ, viscosity nke usoro, na nkwụsi ike nke emulsions ma ọ bụ nkwusioru.

mgbe HPMC bụ n'ozuzu soluble n'elu a mbara pH nso, ya solubility omume nwere ike na-ọma-ekiri site n'ịgbanwe pH nke ngwọta na-ahọpụta kwesịrị ekwesị ọkwa nke HPMC dabere na chọrọ ngwa.