Uru nke ọkwa ọgwụ HPMC

HPMC hydroxypropyl methylcelluloseaghọwo otu n'ime ndị kasị ibu ọgwụ excipients n'ụlọ na ná mba ọzọ, n'ihi na HPMC nwere uru na ndị ọzọ excipients enweghị.

1. Mmiri solubility

Ọ bụ soluble na mmiri oyi n'okpuru 40 ℃ ma ọ bụ 70% ethanol, na ọ bụ isi insoluble na mmiri ọkụ n'elu 60 ℃, ma ọ nwere ike gelled.

2. Chemical inert

HPMC bụ ụdị ether cellulose na-abụghị ionic. Ngwọta ya anaghị ebu ụgwọ ionic ma ọ dịghị emekọ ya na nnu ígwè ma ọ bụ ogige ionic organic. Ya mere, ndị ọzọ excipients adịghị emeghachi omume na ya n'oge usoro nkwadebe.

3. Nkwụsi ike

O siri ike na acid na alkali, enwere ike ịchekwa ya ogologo oge n'etiti pH 3 ~ 11, na viscosity ya enweghị mgbanwe doro anya. The aqueous ngwọta nke HPMC nwere mgbochi mildew mmetụta na ike ịnọgide na-enwe ezi viscosity kwụsie ike n'oge ogologo oge nchekwa. Ndị na-emepụta ọgwụ na-ejiHPMCnwee nkwụsi ike dị mma karịa ndị na-eji ihe mgbakwunye ọdịnala (dị ka dextrin, starch, wdg).

4. Mgbanwe nke viscosity

Enwere ike ịgwakọta ihe dị iche iche viscosity nke HPMC n'ụzọ dị iche iche, na viscosity ya nwere ike ịgbanwe dịka otu iwu siri dị, ma nwee mmekọrịta dị mma na linear, n'ihi ya, enwere ike ịhọrọ ya dị ka ihe achọrọ si dị. 2.5 Metabolic inertia HPMC anaghị etinye uche ma ọ bụ metabolized n'ime ahụ, ọ naghị enye calorie, yabụ na ọ bụ ihe nchekwa dị mma maka nkwadebe ọgwụ. .

5. Nchekwa

A na-ewerekarị yaHPMCbụ ihe na-adịghị egbu egbu na enweghị mgbakasị ahụ.

HPMC-ọkwa ọgwụ bụ ihe dị mkpa akụrụngwa maka mmepụta nke nkwado ntọhapụ na-achịkwa ma na-achịkwa. Ọ bụ ihe mgbakwunye ọgwụ nke steeti na-akwado maka nyocha na mmepe, yana dabara na ntụzịaka mmepe nke iwu ụlọ ọrụ mba na-akwado. Pharmaceutical-ọkwa HPMC bụ isi akụrụngwa maka mmepụta nke HPMC osisi capsules, aza ihe karịrị 90% nke akụrụngwa nke HPMC osisi capsules. Capsules osisi ndị a na-emepụta nwere uru nke nchekwa na ịdị ọcha, ngwa ngwa dị ukwuu, enweghị ihe ize ndụ nke mmeghachi omume na-ejikọta ọnụ, na nkwụsi ike dị elu, nke kwekọrọ na atụmanya ndị ahịa. Nchekwa na idebe ihe ọcha chọrọ nri na ọgwụ bụ otu n'ime ihe mgbakwunye dị mkpa na ezigbo ngwaahịa nnọchi maka capsules gelatin anụmanụ.