Hydroxypropyl methylcellulose (HPMC)yog ib qho non-ionic cellulose ether dav siv hauv cov khoom siv hauv tsev, tshuaj, zaub mov, tshuaj pleev ib ce thiab lwm yam kev lag luam. Nws muaj ntau yam zoo ntawm lub cev, uas ua rau nws ua tau zoo nyob rau hauv ntau yam kev siv.
1. Cov tsos thiab solubility
HPMC feem ntau yog cov hmoov dawb lossis dawb dawb, tsis muaj ntxhiab, tsis qab thiab tsis muaj tshuaj lom. Nws tuaj yeem yaj hauv dej txias thiab qee cov kuab tshuaj organic (xws li cov kuab tshuaj sib xyaw xws li ethanol / dej thiab acetone / dej), tab sis yog insoluble hauv ntshiab ethanol, ether thiab chloroform. Vim nws qhov xwm txheej tsis-ionic, nws yuav tsis raug cov tshuaj tiv thaiv electrolytic hauv cov kua dej thiab yuav tsis cuam tshuam los ntawm pH tus nqi.
2. Viscosity thiab rheology
HPMC aqueous tov muaj cov thickening zoo thiab thixotropy. Ntau hom AnxinCel®HPMC muaj cov viscosities sib txawv, thiab qhov sib txawv yog 5 txog 100000 mPa·s (2% aqueous tov, 20 ° C). Nws cov ntsiab lus nthuav tawm pseudoplasticity, uas yog, shear thinning tshwm sim, thiab yog haum rau daim ntawv thov scenarios xws li txheej, slurries, adhesives, thiab lwm yam uas yuav tsum tau zoo rheology.
3. Thermal gelation
Thaum HPMC yog cua sov hauv dej, lub pob tshab ntawm cov tshuaj txo qis thiab cov gel yog tsim ntawm ib qho kub. Tom qab txias, lub xeev gel yuav rov qab mus rau lub xeev cov tshuaj. Ntau hom HPMC muaj qhov sib txawv gel kub, feem ntau ntawm 50 thiab 75 ° C. Cov cuab yeej no tseem ceeb tshwj xeeb hauv kev siv xws li lub tsev mortar thiab cov tshuaj ntsiav tshuaj.
4. Kev ua haujlwm saum npoo av
Vim tias HPMC cov molecules muaj cov pab pawg hydrophilic thiab hydrophobic, lawv qhia qee yam kev ua ub no thiab tuaj yeem ua lub luag haujlwm emulsifying, dispersing thiab stabilizing. Piv txwv li, hauv cov coatings thiab emulsions, HPMC tuaj yeem txhim kho kev ruaj ntseg ntawm emulsion thiab tiv thaiv cov sedimentation ntawm cov xim xim.
5. Hygroscopicity
HPMC muaj qee yam hygroscopicity thiab tuaj yeem nqus dej noo hauv qhov chaw ntub dej. Yog li ntawd, nyob rau hauv ib co kev siv, yuav tsum tau them nyiaj mloog mus rau ntim sealing kom tsis txhob ya raws thiab agglomeration.
6. Cov cuab yeej ua yeeb yaj kiab
HPMC tuaj yeem tsim cov yeeb yaj kiab tawv thiab pob tshab, uas yog siv dav hauv cov khoom noj, tshuaj (xws li cov tshuaj pleev xim) thiab txheej txheej. Piv txwv li, hauv kev lag luam tshuaj, HPMC zaj duab xis tuaj yeem siv los ua cov ntsiav tshuaj txheej los txhim kho cov tshuaj ruaj khov thiab tswj kev tso tawm.
7. Biocompatibility thiab kev nyab xeeb
HPMC tsis muaj tshuaj lom thiab tsis muaj mob, thiab tuaj yeem ua rau tib neeg lub cev muaj kev nyab xeeb, yog li nws tau siv dav hauv kev lag luam tshuaj thiab zaub mov. Raws li ib qho tshuaj excipient, nws feem ntau yog siv los tsim cov ntsiav tshuaj uas tau tso tawm, capsule plhaub, thiab lwm yam.
8. pH stability ntawm kev daws
HPMC yog ruaj khov nyob rau hauv pH ntau ntawm 3 txog 11, thiab tsis yooj yim degraded los yog precipitated los ntawm acid thiab alkali, yog li nws yuav siv tau nyob rau hauv ntau yam tshuaj, xws li cov khoom siv tsev, cov khoom siv tshuaj txhua hnub thiab tshuaj formulations.
9. Ntsev tsis kam
HPMC kev daws teeb meem yog qhov ruaj khov rau cov ntsev inorganic thiab tsis yooj yim los nag lossis tsis muaj txiaj ntsig vim muaj kev hloov pauv hauv ion concentration, uas ua rau nws muaj kev ua tau zoo hauv qee cov ntsev ntsev (xws li cov cement mortar).
10. Thermal stability
AnxinCel®HPMC muaj kev ruaj ntseg zoo nyob rau hauv qhov kub thiab txias, tab sis nws yuav degrade los yog discolor thaum raug kub kub rau lub sij hawm ntev. Nws tseem tuaj yeem tswj tau qhov kev ua tau zoo nyob rau hauv qee qhov kub thiab txias (feem ntau qis dua 200 ° C), yog li nws tsim nyog rau kev ua haujlwm kub kub.
11. Tshuaj stability
HPMCNws yog ib qho ruaj khov rau lub teeb, oxidants thiab tshuaj lom neeg, thiab tsis yooj yim cuam tshuam los ntawm lwm yam tshuaj lom neeg. Yog li ntawd, nws tuaj yeem siv rau hauv cov khoom uas yuav tsum tau khaws cia ntev, xws li cov khoom siv hauv tsev thiab tshuaj.
Hydroxypropyl methylcellulose yog dav siv nyob rau hauv ntau industries vim nws zoo heev solubility, thickening, thermal gelation, film-forming zog thiab tshuaj stability. Hauv kev tsim kho kev lag luam, nws tuaj yeem siv los ua cov cement mortar thickener; nyob rau hauv kev lag luam kws tshuaj, nws yuav siv tau raws li ib tug kws excipient; nyob rau hauv kev lag luam khoom noj khoom haus, nws yog ib qho khoom noj additive. Nws yog cov khoom tshwj xeeb ntawm lub cev uas ua rau HPMC yog ib qho tseem ceeb ntawm cov khoom siv polymer.
Lub sij hawm xa tuaj: Feb-10-2025