HEC (Hydroxyethyl Cellulose)yog ib hom dej-soluble polymer dav siv hauv kev npaj tshuaj. Nws yog derivative ntawm cellulose, tau los ntawm reacting ethanolamine (ethylene oxide) nrog cellulose. Vim nws zoo solubility, stability, viscosity adjustment muaj peev xwm thiab biocompatibility, HEC muaj ntau yam kev siv nyob rau hauv lub chaw kws tshuaj, tshwj xeeb tshaj yog nyob rau hauv lub formulation txoj kev loj hlob, ntau npaum li cas daim ntawv tsim thiab kev tso tawm tshuaj tswj cov tshuaj.
1. Cov khoom tseem ceeb ntawm HEC
HEC, raws li kev hloov kho cellulose, muaj cov yam ntxwv hauv qab no:
Dej solubility: AnxinCel®HEC tuaj yeem tsim cov kua dej khov hauv dej, thiab nws cov solubility muaj feem xyuam rau qhov kub thiab txias. Cov cuab yeej no ua rau nws siv ntau hom tshuaj xws li qhov ncauj thiab tshuaj pleev.
Biocompatibility: HEC tsis muaj tshuaj lom thiab tsis ua rau tib neeg lub cev thiab sib haum nrog ntau yam tshuaj. Yog li ntawd, nws yog dav siv nyob rau hauv sustained-tso tawm cov ntaub ntawv thiab cov kev tswj xyuas hauv zos cov ntaub ntawv ntawm cov tshuaj.
Adjustable viscosity: Lub viscosity ntawm HEC tuaj yeem hloov kho los ntawm kev hloov nws qhov hnyav molecular lossis concentration, uas yog qhov tseem ceeb rau kev tswj cov tshuaj tso tawm lossis txhim kho kev ruaj ntseg ntawm cov tshuaj.
2. Kev siv HEC hauv kev npaj tshuaj
Raws li ib qho tseem ceeb excipient hauv kev npaj tshuaj, HEC muaj ntau yam haujlwm. Cov hauv qab no yog nws cov chaw siv tseem ceeb hauv kev npaj tshuaj.
2.1 Daim ntawv thov hauv qhov ncauj npaj
Nyob rau hauv cov ntaub ntawv ntawm qhov ncauj noj, HEC feem ntau yog siv nyob rau hauv zus tau tej cov ntsiav tshuaj, tsiav tshuaj thiab ua kua. Nws lub luag haujlwm tseem ceeb suav nrog:
Binder: Hauv cov ntsiav tshuaj thiab granules, HEC tuaj yeem siv los ua cov ntawv khi kom zoo dua khi cov tshuaj los yog hmoov ua ke kom ntseeg tau tias cov tawv tawv thiab ruaj khov ntawm cov ntsiav tshuaj.
Kev tswj kev tso tawm tsis tu ncua: HEC tuaj yeem ua tiav cov txiaj ntsig tso tawm los ntawm kev tswj hwm tus nqi tso tawm ntawm cov tshuaj. Thaum HEC siv ua ke nrog lwm cov khoom xyaw (xws li polyvinyl pyrrolidone, carboxymethyl cellulose, thiab lwm yam), nws tuaj yeem ua kom lub sijhawm tso tawm ntawm cov tshuaj hauv lub cev, txo qhov zaus ntawm cov tshuaj, thiab txhim kho kev ua raws li tus neeg mob.
Thickener: Hauv cov kua hauv qhov ncauj npaj, AnxinCel®HEC ua cov thickener tuaj yeem txhim kho qhov saj ntawm cov tshuaj thiab kev ruaj ntseg ntawm daim ntawv ntau npaum.
2.2 Daim ntawv thov hauv kev npaj tshuaj
HEC yog dav siv nyob rau hauv cov tshuaj pleev ib ce, cream, gels, lotions thiab lwm yam kev npaj, ua si ntau lub luag hauj lwm:
Gel matrix: HEC feem ntau yog siv los ua ib qho matrix rau gels, tshwj xeeb tshaj yog nyob rau hauv transdermal kev xa tshuaj. Nws tuaj yeem muab qhov tsim nyog sib xws thiab nce lub sijhawm nyob ntawm cov tshuaj ntawm daim tawv nqaij, yog li txhim kho kev ua tau zoo.
Viscosity thiab stability: Lub viscosity ntawm HEC tuaj yeem txhim kho qhov adhesion ntawm cov tshuaj pleev xim rau ntawm daim tawv nqaij thiab tiv thaiv cov tshuaj los ntawm kev poob ntxov ntxov vim yog lwm yam xws li kev sib txhuam lossis kev ntxuav. Tsis tas li ntawd, HEC tuaj yeem txhim kho kev ruaj ntseg ntawm cov tshuaj nplaum thiab cov tshuaj pleev thiab tiv thaiv kev stratification lossis crystallization.
Lubricant thiab moisturizer: HEC muaj cov khoom zoo moisturizing thiab tuaj yeem pab ua kom cov tawv nqaij noo thiab tiv thaiv kom qhuav, yog li nws kuj tseem siv rau cov khoom siv moisturizers thiab lwm yam khoom tu tawv nqaij.
2.3 Daim ntawv thov hauv kev npaj kho qhov muag
Daim ntawv thov ntawm HEC hauv kev npaj kho qhov muag yog qhov tseem ceeb hauv nws lub luag haujlwm raws li cov nplaum thiab roj nplaum:
Ophthalmic gels thiab qhov muag tee: HEC tuaj yeem siv los ua cov nplaum rau kev npaj kho qhov muag kom ntev lub sij hawm sib cuag ntawm cov tshuaj thiab qhov muag thiab xyuas kom cov tshuaj txuas ntxiv mus. Nyob rau tib lub sijhawm, nws cov viscosity tseem tuaj yeem tiv thaiv qhov muag tee los ntawm kev poob sai heev thiab ua rau lub sijhawm khaws cov tshuaj.
Lubrication: HEC muaj hydration zoo thiab tuaj yeem muab lubrication tas li hauv kev kho mob ntawm cov kab mob ophthalmic xws li qhov muag qhuav, txo qhov muag tsis pom kev.
2.4 Daim ntawv thov hauv kev npaj txhaj tshuaj
HEC kuj tseem tuaj yeem siv rau hauv kev npaj cov ntawv txhaj tshuaj, tshwj xeeb tshaj yog nyob rau hauv kev txhaj tshuaj ntev ntev thiab kev npaj tso tawm. Lub luag haujlwm tseem ceeb ntawm HEC hauv cov kev npaj no suav nrog:
Thickener thiab stabilizer: Hauv kev txhaj tshuaj,HECtuaj yeem ua kom cov viscosity ntawm cov tshuaj, maj mam txo qhov kev txhaj tshuaj ceev ntawm cov tshuaj, thiab txhim khu kev ruaj ntseg ntawm cov tshuaj.
Kev tswj cov tshuaj tso tawm: Raws li ib qho ntawm cov khoom siv ntawm cov tshuaj tiv thaiv-tso tawm, HEC tuaj yeem tswj tau qhov tso tawm ntawm cov tshuaj los ntawm kev tsim cov gel txheej tom qab txhaj tshuaj, kom ua tiav lub hom phiaj ntawm kev kho mob mus ntev.
3. Lub luag haujlwm ntawm HEC hauv kev xa tshuaj
Nrog rau txoj kev loj hlob ntawm cov cuab yeej siv tshuaj, HEC tau siv dav hauv ntau lub tshuab xa tshuaj, tshwj xeeb tshaj yog nyob rau hauv thaj chaw ntawm nano-drug carriers, microspheres, thiab cov neeg nqa tshuaj tiv thaiv kev tso tawm. HEC tuaj yeem ua ke nrog ntau yam khoom nqa tshuaj los tsim ib qho chaw ruaj khov kom ntseeg tau tias kev tso tawm thiab xa cov tshuaj tau zoo.
Nano tshuaj cab cab: HEC tuaj yeem siv los ua kom ruaj khov rau cov neeg nqa tshuaj nano los tiv thaiv kev sib sau lossis nag lossis daus ntawm cov khoom nqa khoom thiab ua kom cov tshuaj bioavailability.
Microspheres thiab hais: HEC tuaj yeem siv los npaj cov microspheres thiab microparticle cov neeg nqa tshuaj kom ntseeg tau tias cov tshuaj tso tawm qeeb hauv lub cev thiab txhim kho kev ua tau zoo ntawm cov tshuaj.
Raws li kev siv tshuaj ntau thiab muaj txiaj ntsig zoo, AnxinCel®HEC muaj cov ntawv thov dav dav hauv kev npaj tshuaj. Nrog kev txhim kho txuas ntxiv ntawm cov cuab yeej siv tshuaj, HEC ua lub luag haujlwm tseem ceeb hauv kev tswj cov tshuaj tso tawm, kev tswj hwm hauv zos, kev npaj tso tawm thiab kev xa tshuaj tshiab. Nws zoo biocompatibility, adjustable viscosity thiab stability ua rau nws irreplaceable nyob rau hauv cov tshuaj. Nyob rau hauv lub neej yav tom ntej, nrog rau kev kawm tob ntawm HEC, nws daim ntawv thov nyob rau hauv kev npaj tshuaj yuav ntau thiab ntau haiv neeg.
Post lub sij hawm: Dec-28-2024