Ntau yam ntawm Hydroxypropyl Methylcellulose Gel Kub

Hydroxypropyl Methylcellulose (HPMC)yog ib qho polymer uas yaj tau hauv dej uas feem ntau siv rau hauv kev lag luam tshuaj, tshuaj pleev ib ce thiab khoom noj. Vim nws cov khoom zoo heev uas yaj tau hauv dej thiab hloov kho viscosity, HPMC siv dav hauv cov gels, cov tshuaj tswj kev tso tawm tshuaj, cov tshuaj ncua, cov khoom ua kom tuab thiab lwm yam teb. Ntau hom thiab cov lus qhia ntawm HPMC muaj ntau qhov kub thiab txias sib txawv, tshwj xeeb tshaj yog thaum npaj HPMC gels, qhov kub thiab txias muaj qhov cuam tshuam tseem ceeb rau nws cov solubility, viscosity thiab kev ruaj khov.

HPMC yaj thiab gel tsim kub ntau yam

Kub yaj
HPMC feem ntau yaj hauv dej nrog dej kub, thiab qhov kub yaj nyob ntawm nws qhov hnyav molecular thiab qib ntawm methylation thiab hydroxypropylation. Feem ntau hais lus, qhov kub yaj ntawm HPMC yog txij li 70 ° C txog 90 ° C, thiab qhov kub yaj tshwj xeeb yog cuam tshuam los ntawm cov lus qhia ntawm HPMC thiab qhov concentration ntawm cov tshuaj. Piv txwv li, HPMC qis-viscosity feem ntau yaj ntawm qhov kub qis dua (kwv yees li 70 ° C), thaum HPMC siab-viscosity yuav xav tau qhov kub siab dua (ze li 90 ° C) kom yaj tag.

Kub ntawm kev tsim gel (Kub ntawm kev tsim gelation)
HPMC muaj ib qho tshwj xeeb thermoreversible gel khoom, uas yog, nws yuav tsim ib tug gel nyob rau hauv ib tug tej yam kub ntau yam. Lub kub ntau yam ntawm HPMC gel yog feem ntau cuam tshuam los ntawm nws cov molecular qhov hnyav, cov qauv tshuaj, cov tshuaj concentration thiab lwm yam additives. Feem ntau hais lus, lub kub ntau yam ntawm HPMC gel yog 35 ° C txog 60 ° C. Nyob rau hauv lub ntau yam no, cov HPMC molecular saw yuav rearranged los ua ib tug peb-dimensional network qauv, ua rau cov tshuaj hloov los ntawm ib tug kua xeev mus rau ib tug gel xeev.

Qhov kub tshwj xeeb ntawm kev tsim cov gel (piv txwv li, qhov kub ntawm gelation) tuaj yeem txiav txim siab los ntawm kev sim. Qhov kub ntawm gelation ntawm HPMC gel feem ntau nyob ntawm cov hauv qab no:

Qhov hnyav molecular: HPMC nrog qhov hnyav molecular siab tuaj yeem tsim cov gel ntawm qhov kub qis dua.

Kev Ntsuas Cov Tshuaj: Qhov kev ntsuas siab dua ntawm cov tshuaj, qhov kub ntawm kev tsim cov gel feem ntau qis dua.

Qib ntawm methylation thiab qib ntawm hydroxypropylation: HPMC nrog qib siab ntawm methylation feem ntau tsim cov gel ntawm qhov kub qis dua vim tias methylation ua rau muaj kev sib cuam tshuam ntawm cov molecules.

Cov nyhuv ntawm qhov kub thiab txias
Hauv kev siv ua haujlwm, qhov kub thiab txias muaj qhov cuam tshuam loj rau kev ua haujlwm thiab kev ruaj khov ntawm HPMC gel. Qhov kub siab dua ua rau cov saw hlau ntawm HPMC molecular nce ntxiv, yog li cuam tshuam rau qhov ruaj khov thiab cov yam ntxwv ntawm cov gel. Ntawm qhov tsis sib xws, qhov kub qis tuaj yeem ua rau cov dej ntawm HPMC gel tsis muaj zog thiab ua rau cov qauv gel tsis ruaj khov. Tsis tas li ntawd, kev hloov pauv kub kuj tseem tuaj yeem ua rau muaj kev sib cuam tshuam ntawm HPMC molecules thiab kev hloov pauv ntawm viscosity ntawm cov tshuaj.

Kev coj tus cwj pwm ntawm HPMC gelation ntawm pH sib txawv thiab lub zog ionic

Tus cwj pwm gelation ntawm HPMC tsis yog tsuas yog cuam tshuam los ntawm qhov kub thiab txias xwb, tab sis kuj los ntawm pH thiab lub zog ionic ntawm cov tshuaj. Piv txwv li, qhov solubility thiab gelation ntawm HPMC ntawm cov nqi pH sib txawv yuav txawv. Qhov solubility ntawm HPMC yuav raug txo qis hauv cov chaw acidic, thaum nws qhov solubility yuav raug nce hauv cov chaw alkaline. Ib yam li ntawd, qhov nce ntawm lub zog ionic (xws li kev ntxiv ntsev) yuav cuam tshuam rau kev sib cuam tshuam ntawm HPMC molecules, yog li hloov pauv qhov tsim thiab kev ruaj khov ntawm gel.

Daim ntawv thov ntawm HPMC gel thiab nws cov yam ntxwv kub

Cov yam ntxwv kub ntawm HPMC gel ua rau nws siv dav hauv kev tso tshuaj, kev npaj tshuaj pleev ib ce thiab lwm yam teb:

Kev tso tshuaj uas tswj tau
Hauv kev npaj tshuaj, HPMC feem ntau siv ua cov khoom tso tawm tswj, thiab nws cov khoom gelation siv los tswj qhov kev tso tawm ntawm cov tshuaj. Los ntawm kev kho qhov concentration thiab gelation kub ntawm HPMC, kev tso tawm ntawm cov tshuaj tuaj yeem tswj tau meej. Kev hloov pauv kub ntawm cov tshuaj hauv txoj hnyuv plab tuaj yeem txhawb nqa qhov o ntawm HPMC gel thiab maj mam tso tawm cov tshuaj.

Cov Tshuaj Pleev Xim thiab Cov Khoom Siv Kho Mob Tus Kheej
HPMC feem ntau siv rau hauv cov tshuaj pleev ib ce xws li tshuaj pleev, gels, tshuaj tsuag plaub hau, thiab tshuaj pleev tawv nqaij. Vim nws qhov kub thiab txias, HPMC tuaj yeem kho qhov zoo nkauj thiab ruaj khov ntawm cov khoom nyob rau hauv ntau qhov kub thiab txias. Kev hloov pauv kub hauv cov qauv tshuaj pleev ib ce muaj qhov cuam tshuam loj rau tus cwj pwm gelation ntawm HPMC, yog li cov lus qhia HPMC tsim nyog yuav tsum tau xaiv kom zoo thaum tsim cov khoom.

Kev Lag Luam Khoom Noj
Hauv cov khoom noj, HPMC siv dav ua cov khoom ua kom tuab thiab emulsifier, tshwj xeeb tshaj yog hauv cov khoom noj thiab dej haus uas npaj txhij noj. Nws cov khoom rhiab heev rau qhov kub thiab txias ua rau HPMC hloov nws lub cev thaum lub sijhawm cua sov lossis txias, yog li cuam tshuam rau saj thiab cov qauv ntawm cov khoom noj.

Cov yam ntxwv ntawm qhov kub thiab txiasHPMCCov gels yog ib qho tseem ceeb hauv lawv daim ntawv thov. Los ntawm kev kho qhov kub thiab txias, kev sib xyaw, thiab kev hloov pauv tshuaj lom neeg, cov khoom ntawm HPMC gels, xws li solubility, gel lub zog, thiab kev ruaj khov, tuaj yeem tswj tau meej. Qhov kub ntawm kev tsim gel feem ntau yog ntawm 35 ° C thiab 60 ° C, thaum nws qhov kub yaj feem ntau yog 70 ° C txog 90 ° C. HPMC yog siv dav hauv kev lag luam tshuaj, tshuaj pleev ib ce, thiab zaub mov vim nws tus cwj pwm thermoreversible gelation thiab qhov kub rhiab heev.