Hydroxypropylmethylcellulose (HPMC) yog cov polymer yaj hauv dej uas siv dav hauv ntau yam lag luam xws li tshuaj, khoom noj, tshuaj pleev ib ce, thiab kev tsim kho. HPMC paub txog nws cov khoom zoo heev uas khaws dej tau zoo, ua rau nws yog cov khoom xyaw zoo tshaj plaws hauv ntau daim ntawv thov. Hauv tsab xov xwm no, peb tshuaj xyuas cov yam ntxwv uas cuam tshuam rau kev khaws dej ntawm HPMC thiab yuav ua li cas kom zoo dua cov yam ntxwv no kom ua tau zoo tshaj plaws.
1. Qhov hnyav ntawm cov molecule
Qhov hnyav molecular ntawm HPMC ua lub luag haujlwm tseem ceeb hauv nws cov khoom khaws dej. Qhov hnyav molecular siab dua, qhov muaj peev xwm khaws dej ntau dua. Qhov no yog vim tias qhov hnyav molecular siab HPMC muaj viscosity siab dua, uas ua rau nws tsim cov zaj duab xis tuab dua ntawm qhov chaw ntawm lub substrate, yog li txo qhov poob dej. Yog li ntawd, rau cov ntawv thov uas qhov kev khaws dej tseem ceeb, qhov hnyav molecular siab HPMC raug pom zoo.
2. Qib ntawm kev hloov pauv
Qhov degree of substitution (DS) yog hais txog tus naj npawb ntawm hydroxypropyl thiab methyl pawg hauv HPMC molecule. Qhov siab dua DS, qhov ntau dua qhov muaj peev xwm khaws dej. Qhov no yog vim tias hydroxypropyl thiab methyl pawg ua rau HPMC yaj tau zoo dua hauv dej thiab txhim kho nws lub peev xwm los tsim cov gel zoo li uas tuaj yeem haum rau cov dej molecules. Yog li ntawd, rau cov ntawv thov uas qhov kev khaws dej yog qhov tseem ceeb, HPMC nrog qib siab ntawm kev hloov pauv yog qhov pom zoo.
3. Kub thiab av noo
Kub thiab av noo yog cov yam tseem ceeb uas cuam tshuam rau kev khaws dej ntawm HPMC. Kub siab thiab av noo qis yuav ua rau cov dej hauv zaj duab xis HPMC qhuav sai, ua rau tsis khaws dej zoo. Yog li ntawd, nws raug pom zoo kom khaws HPMC rau qhov chaw txias thiab qhuav kom tswj tau nws cov khoom khaws dej.
4. Tus nqi pH
Lub pH ntawm lub substrate kuj ua lub luag haujlwm tseem ceeb hauv kev khaws dej ntawm HPMC. HPMC zoo tshaj plaws hauv qhov chaw nruab nrab mus rau qhov chaw acidic me ntsis. Thaum lub pH ntawm lub matrix siab, qhov solubility ntawm HPMC yuav raug txo thiab cov dej khaws cia yuav raug txo. Yog li ntawd, nws raug pom zoo kom sim lub pH ntawm lub substrate thiab kho nws mus rau qhov ntau thiab tsawg kom zoo rau kev khaws dej zoo tshaj plaws.
5. Kev Ntsuas
Qhov concentration ntawm HPMC kuj cuam tshuam rau nws cov khoom khaws dej. Feem ntau, qhov concentration siab dua ntawm HPMC, qhov zoo dua qhov khaws dej. Txawm li cas los xij, ntawm qhov concentration siab heev, qhov viscosity ntawm HPMC tuaj yeem siab dhau, ua rau nws nyuaj rau thov thiab nthuav dav sib npaug ntawm cov substrate. Yog li ntawd, nws raug pom zoo kom sim qhov concentration zoo tshaj plaws ntawm HPMC rau txhua daim ntawv thov tshwj xeeb kom ua tiav qhov khaws dej zoo tshaj plaws.
Xaus lus, HPMC tau dhau los ua cov khoom siv tseem ceeb vim nws cov khoom zoo heev rau kev khaws dej thiab ua lub luag haujlwm tseem ceeb hauv ntau yam lag luam. Cov yam ntxwv uas cuam tshuam rau nws cov dej khaws cia, xws li qhov hnyav molecular, qib kev hloov pauv, kub thiab av noo, pH thiab concentration, tuaj yeem ua kom zoo dua los ua kom nws muaj txiaj ntsig zoo tshaj plaws. Los ntawm kev nkag siab txog cov yam ntxwv no, peb tuaj yeem ua kom ntseeg tau tias HPMCs ua tiav lawv lub peev xwm tag nrho, ua rau muaj kev tsim cov khoom lag luam zoo rau lawv cov khoom khaws cia dej.
Lub sijhawm tshaj tawm: Lub Xya Hli-04-2023