Hydroxypropyl methylcellulose (HPMC)yog ib qho tshuaj polymer uas siv ntau hauv dej, siv dav hauv tshuaj, khoom noj, cov ntaub ntawv tsim kho, tshuaj pleev ib ce thiab lwm yam teb. HPMC muaj cov yam ntxwv solubility zoo thiab viscosity thiab tuaj yeem tsim cov tshuaj colloidal ruaj khov, yog li nws ua lub luag haujlwm tseem ceeb hauv ntau daim ntawv thov. Yuav kom muab kev ua si tag nrho rau kev ua haujlwm ntawm HPMC, txoj kev yaj kom raug yog qhov tseem ceeb heev.
1. Txoj kev yaj dej kub li qub
HPMC tuaj yeem yaj rau hauv dej txias, tab sis feem ntau xav tau qee qhov kev txawj ntse kom tsis txhob muaj kev sib sau ua ke. Txhawm rau txhim kho cov txiaj ntsig ntawm kev yaj, cov kauj ruam hauv qab no tuaj yeem siv:
Kauj Ruam 1: Ntxiv HPMC rau hauv dej
Thaum sov li chav tsev, ua ntej muab HPMC nchuav rau ntawm qhov chaw dej kom tsis txhob nchuav HPMC ntau ntau rau hauv dej ib zaug. Vim tias HPMC yog cov khoom sib xyaw polymer, ntxiv HPMC ntau ntau ncaj qha yuav ua rau nws nqus dej thiab o sai sai hauv dej los ua cov tshuaj zoo li gel.
Kauj Ruam 2: Sib tov
Tom qab ntxiv HPMC, txuas ntxiv do kom sib npaug. Vim tias HPMC muaj cov khoom me me, nws yuav o tom qab nqus dej los ua cov khoom zoo li gel. Kev do pab tiv thaiv HPMC kom tsis txhob sib sau ua pawg.
Kauj Ruam 3: Sawv ntsug thiab do ntxiv
Yog tias HPMC tsis tau yaj tag, cov tshuaj no tuaj yeem tso rau ib pliag thiab tom qab ntawd txuas ntxiv do. Feem ntau nws yuav yaj tag hauv ob peb teev.
Txoj kev no yog qhov tsim nyog rau cov sijhawm uas tsis tas yuav muaj cua sov, tab sis nws siv sijhawm ntev kom ntseeg tau tias HPMC yaj tag.
2. Txoj kev yaj dej kub
HPMC yaj sai dua hauv dej sov, yog li cua sov qhov kub ntawm dej tuaj yeem ua kom cov txheej txheem yaj sai dua. Qhov kub ntawm dej kub uas siv feem ntau yog 50-70 ℃, tab sis qhov kub siab dhau (xws li tshaj 80 ℃) yuav ua rau HPMC puas tsuaj, yog li qhov kub yuav tsum tau tswj.
Kauj Ruam 1: Ua kom dej sov
Ua kom dej kub txog li 50 ℃ thiab ua kom nws tsis tu ncua.
Kauj Ruam 2: Ntxiv HPMC
Maj mam muab HPMC nchuav rau hauv dej kub. Vim yog qhov kub ntawm dej siab, HPMC yuav yaj yooj yim dua, txo qhov sib sau ua ke.
Kauj Ruam 3: Sib tov
Tom qab ntxiv HPMC, txuas ntxiv do cov kua dej. Kev sib xyaw ua ke ntawm kev ua kom sov thiab kev do tuaj yeem txhawb kev yaj sai ntawm HPMC.
Kauj Ruam 4: Tswj qhov kub thiab txuas ntxiv do
Koj tuaj yeem tswj tau qhov kub thiab txuas ntxiv do kom txog thaum HPMC yaj tag.
3. Txoj Kev Yaj Cawv
HPMC tsis yog tsuas yog yaj tau hauv dej xwb, tab sis kuj tseem yaj tau hauv qee cov kuab tshuaj cawv (xws li ethanol). Qhov zoo tshaj plaws ntawm txoj kev yaj cawv yog tias nws tuaj yeem txhim kho qhov solubility thiab dispersibility ntawm HPMC, tshwj xeeb tshaj yog rau cov kab ke uas muaj cov dej ntau.
Kauj Ruam 1: Xaiv cov tshuaj yaj cawv uas tsim nyog
Cov tshuaj yaj cawv xws li ethanol thiab isopropanol feem ntau siv los yaj HPMC. Feem ntau hais lus, 70-90% ethanol kua muaj cov nyhuv zoo dua rau kev yaj HPMC.
Kauj Ruam 2: Kev Tshem Tawm
Maj mam muab HPMC nchuav rau hauv cov cawv uas muaj kuab tshuaj, do thaum ntxiv kom ntseeg tau tias HPMC tau tawg tag.
Kauj Ruam 3: Sawv ntsug thiab do
Cov txheej txheem ntawm cov kuab tshuaj cawv yaj HPMC yog qhov ceev heev, thiab feem ntau nws siv sijhawm ob peb feeb kom ua tiav kev yaj tag.
Txoj kev yaj cawv feem ntau yog siv rau hauv cov xwm txheej thov uas xav tau kev yaj sai dua thiab cov dej tsawg dua.
4. Txoj kev sib xyaw ua ke ntawm cov kuab tshuaj thiab dej
Qee zaum HPMC raug yaj rau hauv qhov sib tov ntawm qee qhov feem ntawm dej thiab cov kuab tshuaj. Txoj kev no yog qhov tsim nyog rau cov xwm txheej uas qhov viscosity ntawm cov tshuaj lossis qhov nrawm ntawm kev yaj yuav tsum tau hloov kho. Cov kuab tshuaj feem ntau suav nrog acetone, ethanol, thiab lwm yam.
Kauj Ruam 1: Npaj cov tshuaj
Xaiv qhov sib piv ntawm cov kuab tshuaj thiab dej (piv txwv li 50% dej, 50% kuab tshuaj) thiab cua sov rau qhov kub uas tsim nyog.
Kauj Ruam 2: Ntxiv HPMC
Thaum do, maj mam ntxiv HPMC kom paub tseeb tias sib tov zoo.
Kauj Ruam 3: Kev hloov kho ntxiv
Raws li qhov xav tau, qhov sib piv ntawm dej lossis cov kuab tshuaj tuaj yeem nce ntxiv kom kho qhov solubility thiab viscosity ntawm HPMC.
Txoj kev no yog qhov tsim nyog rau cov sijhawm uas cov organic solvents raug ntxiv rau hauv cov kua dej kom txhim kho qhov nrawm ntawm kev yaj lossis kho cov khoom ntawm cov kua.
5. Txoj kev pab yaj los ntawm ultrasonic
Siv cov nyhuv oscillation siab ntawm ultrasound, txoj kev yaj ultrasonic-assisted tuaj yeem ua kom cov txheej txheem yaj ntawm HPMC sai dua. Txoj kev no yog qhov tsim nyog rau ntau HPMC uas xav tau yaj sai, thiab tuaj yeem txo qhov teeb meem agglomeration uas yuav tshwm sim thaum lub sijhawm do ib txwm muaj.
Kauj Ruam 1: Npaj cov tshuaj
Ntxiv HPMC rau hauv cov dej lossis cov dej-solvent sib xyaw kom haum.
Kauj Ruam 2: Kev kho mob Ultrasonic
Siv lub tshuab ntxuav ultrasonic lossis lub tshuab yaj ultrasonic thiab kho nws raws li lub zog thiab lub sijhawm teem tseg. Cov nyhuv oscillation ntawm ultrasound tuaj yeem ua kom cov txheej txheem yaj ntawm HPMC sai dua.
Kauj Ruam 3: Tshawb xyuas qhov cuam tshuam ntawm kev yaj
Tom qab kho ultrasonic, xyuas seb cov tshuaj puas yaj tag. Yog tias muaj ib feem uas tsis yaj, kev kho ultrasonic tuaj yeem ua dua.
Txoj kev no yog qhov tsim nyog rau cov ntawv thov uas xav tau kev yaj sai thiab zoo.
6. Kev kho ua ntej ua ntej yaj
Yuav kom tsis txhob muaj teeb meemHPMCYog tias muaj kev sib sau ua ke lossis nyuaj rau yaj, qee txoj kev kho ua ntej siv tau, xws li sib tov HPMC nrog me ntsis ntawm lwm cov kuab tshuaj (xws li glycerol), ziab nws ua ntej, lossis ntub HPMC ua ntej ntxiv cov kuab tshuaj. Cov kauj ruam kho ua ntej no tuaj yeem txhim kho qhov solubility ntawm HPMC.
Muaj ntau txoj hauv kev los yaj HPMC. Kev xaiv txoj kev yaj uas tsim nyog tuaj yeem txhim kho qhov ua tau zoo ntawm kev yaj thiab qhov zoo ntawm cov khoom. Txoj kev yaj hauv chav sov yog qhov tsim nyog rau qhov chaw sov dua, txoj kev yaj dej kub tuaj yeem ua kom cov txheej txheem yaj sai dua, thiab txoj kev yaj cawv thiab txoj kev yaj sib xyaw ntawm cov kuab tshuaj thiab dej yog qhov tsim nyog rau kev yaj nrog cov kev xav tau tshwj xeeb. Txoj kev yaj ultrasonic-pab yog ib txoj hauv kev zoo los daws qhov kev yaj sai ntawm ntau HPMC. Raws li cov kev xav tau ntawm daim ntawv thov tshwj xeeb, kev xaiv yooj ywm ntawm txoj kev yaj tsim nyog tuaj yeem ua kom muaj kev ua tau zoo tshaj plaws ntawm HPMC hauv ntau qhov chaw sib txawv.
Lub sijhawm tshaj tawm: Lub Kaum Ob Hlis-19-2024