HPMC puas tuaj yeem yaj hauv dej kub?

HPMC (Hydroxypropyl Methylcellulose)yog ib qho non-ionic semi-synthetic polymer dav siv hauv tshuaj, khoom noj khoom haus, kev tsim kho, txheej thiab lwm yam lag luam. Raws li seb HPMC puas tuaj yeem yaj hauv dej kub, nws cov yam ntxwv solubility thiab qhov cuam tshuam ntawm qhov kub thiab txias ntawm nws tus cwj pwm dissolution yuav tsum xav txog.

Txheej txheem cej luam ntawm HPMC solubility

HPMC muaj dej solubility zoo, tab sis nws cov cwj pwm dissolution yog ze ze rau dej kub. Feem ntau, HPMC tuaj yeem tawg tau yooj yim thiab yaj hauv dej txias, tab sis nws muaj cov yam ntxwv sib txawv hauv dej kub. Kev solubility ntawm HPMC hauv dej txias yog cuam tshuam los ntawm nws cov qauv molecular thiab hloov hom. Thaum HPMC nkag mus rau hauv dej, pawg hydrophilic (xws li hydroxyl thiab hydroxypropyl) hauv nws cov molecules yuav tsim hydrogen bonds nrog dej molecules, ua rau nws maj mam o thiab yaj. Txawm li cas los xij, cov yam ntxwv solubility ntawm HPMC sib txawv hauv dej ntawm qhov sib txawv.

Solubility ntawm HPMC hauv dej kub

Lub solubility ntawm HPMC hauv dej kub nyob ntawm qhov kub thiab txias:

Tsis tshua muaj kub (0-40 ° C): HPMC tuaj yeem maj mam nqus dej thiab o, thiab thaum kawg tsim cov pob tshab los yog cov kua nplaum. Lub dissolution tus nqi yog qeeb qeeb ntawm qhov kub thiab txias, tab sis gelation tsis tshwm sim.

Qhov nruab nrab kub (40-60 ° C): HPMC swells nyob rau hauv qhov kub thiab txias, tab sis tsis yaj tag. Hloov chaw, nws yooj yim tsim tsis sib xws agglomerates los yog ncua kev kawm ntawv, cuam tshuam qhov sib xws ntawm cov tshuaj.

Kev kub siab (siab tshaj 60 ° C): HPMC yuav dhau mus rau theem sib cais ntawm qhov kub siab dua, tshwm sim raws li gelation lossis nag lossis daus, ua rau nws nyuaj rau yaj. Feem ntau hais lus, thaum dej kub siab tshaj 60-70 ° C, lub thermal zog ntawm HPMC molecular saw intensifies, thiab nws solubility txo, thiab nws thiaj li yuav tsim ib gel los yog precipitate.

Thermogel Properties ntawm HPMC

HPMC muaj cov khoom siv thermogel zoo ib yam, uas yog, nws tsim cov gel ntawm qhov kub siab dua thiab tuaj yeem rov ua dua ntawm qhov kub thiab txias. Cov cuab yeej no tseem ceeb heev hauv ntau daim ntawv thov, xws li:

Kev tsim kho kev lag luam: HPMC yog siv los ua cov thickener rau cement mortar. Nws tuaj yeem tswj tau cov dej noo zoo thaum lub sij hawm tsim kho thiab nthuav tawm gelation nyob rau hauv qhov chaw kub kub kom txo tau dej.

Kev npaj tshuaj: Thaum siv los ua cov khoom siv txheej hauv cov ntsiav tshuaj, nws cov khoom siv thermal gelation yuav tsum tau txiav txim siab los xyuas kom meej solubility zoo.

Kev lag luam khoom noj khoom haus: HPMC yog siv los ua cov thickener thiab emulsifier hauv qee cov khoom noj, thiab nws cov thermal gelation pab kev ruaj ntseg ntawm cov zaub mov.

Yuav ua li cas yaj HPMC kom raug?

Txhawm rau zam HPMC los ntawm kev tsim cov gel hauv dej kub thiab tsis ua kom yaj sib npaug, cov hauv qab no feem ntau yog siv:

Cov txheej txheem dej txias dispersion:

Ua ntej, sib npaug sib faib HPMC hauv dej txias lossis chav dej kub kom ntub dej thiab o.

Maj mam nce qhov kub thiab txias thaum lub sij hawm stirring kom yaj HPMC ntxiv.

Tom qab nws tau yaj tag, qhov kub tuaj yeem tsim nyog nce ntxiv kom nrawm tsim cov tshuaj.

Cov dej kub dispersion txias txoj kev:

Ua ntej, siv cov dej kub (kwv yees li 80-90 ° C) kom tawg sai sai HPMC kom cov txheej txheem tiv thaiv tsis muaj kuab lom tau tsim rau ntawm nws qhov chaw kom tsis txhob muaj cov nplaum nplaum tam sim ntawd.

Tom qab txias rau hauv chav sov lossis ntxiv dej txias, HPMC maj mam yaj los ua ib qho kev daws teeb meem.

Dry mixing method:

Sib tov HPMC nrog lwm cov tshuaj soluble (xws li qab zib, hmoov txhuv nplej siab, mannitol, thiab lwm yam) thiab tom qab ntawd ntxiv dej kom txo tau cov agglomeration thiab txhawb kev sib cais.

HPMCtsis tuaj yeem yaj ncaj qha rau hauv dej kub. Nws yog ib qho yooj yim los tsim gel los yog precipitate ntawm qhov kub thiab txias, uas txo nws cov solubility. Txoj kev zoo tshaj plaws yog disperse nyob rau hauv dej txias ua ntej los yog pre-disperse nrog dej kub thiab ces txias kom tau ib tug uniform thiab ruaj khov tov. Hauv cov ntawv thov siv tau, xaiv txoj kev sib cais tsim nyog raws li qhov xav tau los xyuas kom meej tias HPMC ua tau zoo tshaj plaws.