He aha ka hydroxypropyl cellulose i hoʻololi nui ʻia?

ʻO ka hydroxypropyl cellulose (HSHPC) kahi ʻano cellulose i hoʻololi ʻia, he polysaccharide kūlohelohe i loaʻa i nā mea kanu. Hana ʻia kēia derivative ma o ke kaʻina hana hoʻololi kemika kahi i hoʻokomo ʻia ai nā pūʻulu hydroxypropyl i ka iwi kuamoʻo cellulose. Hōʻike ka mea i loaʻa i nā waiwai kūʻokoʻa i mea waiwai i nā ʻano hana ʻenehana a me nā lāʻau lapaʻau.

Hoʻokumu ʻia ka cellulose me nā ʻāpana glucose hou i hoʻopili ʻia e nā paʻa beta-1,4-glycosidic. ʻO ia ka polymer organik nui loa ma ka Honua a lawelawe ʻo ia ma ke ʻano he mea hana i loko o nā paia o nā mea kanu. Eia nō naʻe, he mau palena kona ʻano kūlohelohe ma ke ʻano o ka solubility, nā waiwai rheological, a me ka launa pū me nā mea ʻē aʻe. Ma ka hoʻololi kemika i ka cellulose, hiki i nā ʻepekema ke hoʻololi i kona mau waiwai e kūpono i nā noi kikoʻī.

Hydroxypropyl cellulose (HPC)he mea hoʻohana maʻamau ka cellulose derivative i hana ʻia e ka etherification o cellulose me propylene oxide. Hoʻokomo kēia hoʻololi i nā pūʻulu hydroxypropyl ma ka iwi kuamoʻo cellulose, e hāʻawi ana i ka solubility i ka wai a me nā mea hoʻoheheʻe organik. Eia nō naʻe, ʻaʻole hiki i ka HPC maʻamau ke hoʻokō i nā koi o kekahi mau noi ma muli o kona palena palena o ka hoʻololi ʻana.

ʻO ka hydroxypropyl cellulose i hoʻololi nui ʻia, e like me ka manaʻo o ka inoa, e hana ana i kahi kaʻina hoʻololi ʻoi aku ka nui, e hopena i kahi kiʻekiʻe o ka hoʻololi ʻana me nā hui hydroxypropyl. Hoʻonui kēia hoʻololi hoʻonui i ka solubility o ka polymer, hiki ke pehu, a me nā waiwai hana kiʻiʻoniʻoni, e hoʻohana pono ai i nā noi kūikawā kahi e koʻikoʻi ai kēia mau ʻano.

ʻO ka synthesis o HSHPC ka mea maʻamau e pili ana i ka hopena o ka cellulose me ka propylene oxide i mua o kahi catalyst ma lalo o nā kūlana hoʻomalu. Hiki ke hoʻololi ʻia ke degere o ka hoʻololi ʻana e nā ʻāpana like ʻole e like me ka manawa pane, ka mahana, a me ka ratio o nā reactants. Ma o ka loiloi akahele, hiki i nā mea noiʻi ke hoʻokō i ka pae i makemake ʻia o ka hoʻololi ʻana e hoʻokō i nā pae hoʻokō kikoʻī.

ʻO kekahi o nā noi mua o ka HSHPC aia i loko o ka ʻoihana lāʻau lapaʻau, kahi e lawelawe ai ma ke ʻano he mea hoʻohana nui i nā hoʻomākaukau lāʻau. ʻO nā excipients nā mea hana ʻole i hoʻohui ʻia i nā huahana pharmaceutical e hoʻomaikaʻi i kā lākou hana hana, kūpaʻa, bioavailability, a me ka ʻae ʻana i ka mea maʻi. Mahalo nui ʻia ka HSHPC no kona hiki ke hana ma ke ʻano he mea hoʻopaʻa, disintegrant, kiʻiʻoniʻoni mua, a me ka mea hoʻololi viscosity i nā ʻano ʻano like ʻole.

I nā papa papa, hiki ke hoʻohana ʻia ka HSHPC ma ke ʻano he mea hoʻopaʻa e paʻa i nā mea ikaika, e hōʻoia i ka hāʻawi ʻana i ka lāʻau lapaʻau like ʻole a me ka hāʻawi ʻana i ka dosage mau. Hiki i kona solubility kiʻekiʻe ke hoʻopau koke i nā papa ma ka ʻai ʻana, hoʻomaʻamaʻa i ka hoʻokuʻu ʻana i ka lāʻau a me ka absorption i ke kino. Eia kekahi, kūpono nā waiwai hana kiʻiʻoniʻoni o HSHPC no ka uhi ʻana i nā papa, e hāʻawi ana i ka pale mai ka makū, ka māmā, a me ka oxidation, a me ka uhi ʻana i nā ʻono ʻono a i ʻole nā ​​mea ʻala.

Ma waho aʻe o nā papa, ʻike ʻo HSHPC i nā noi ma nā ʻano hana ʻē aʻe e like me nā granules, pellets, capsules, a me nā ʻano kumuhana. ʻO kona kūlike me ka laulā o nā mea lāʻau lapaʻau ikaika (API) a me nā mea kōkua ʻē aʻe e lilo ia i koho maʻamau no nā mea hoʻopuka e ʻimi nei e hoʻopaʻa i nā ʻōnaehana lawe lāʻau.

Ma waho aʻe o ka ʻoihana lāʻau lapaʻau, hoʻohana ʻia ʻo HSHPC i nā ʻano hana ʻoihana like ʻole, e like me nā mea hoʻopili, nā uhi, nā huahana mālama pilikino, a me nā mea hoʻohui meaʻai. ʻO kāna mau mea hana kiʻiʻoniʻoni a me ka mānoanoa he mea waiwai ia i nā hana hoʻopili no ka pepa, ka ʻeke a me nā mea hana. I nā uhi, hiki i ka HSHPC ke hoʻomaikaʻi i nā waiwai kahe, ka hoʻopili ʻana, a me ka pale ʻana i ka wai o nā pena, nā varnish, a me nā sealants.

I loko o nā huahana mālama pilikino e like me nā mea hoʻonaninani, hana ʻo HSHPC ma ke ʻano he mānoanoa, stabilizer, a me ka emulsifier i loko o nā ʻaila, lotions, shampoos, a me nā gels. ʻO kona hiki ke hoʻonui i ka viscosity a hāʻawi i kahi ʻano maʻalahi, ʻālohilohi ka mea i makemake ʻia i loko o ka nui o ka mālama ʻili a me ka mālama lauoho. Eia kekahi, ʻo ka biocompatibility o HSHPC a me ka non-toxic i kūpono ia no ka hoʻohana ʻana i nā huahana mālama waha e like me ka niho niho a me ka holoi waha.

ʻO ka hydroxypropyl cellulose i hoʻololi nui ʻia he polymer versatile me ka nui o nā noi i nā lāʻau lapaʻau, nā mea hoʻonaninani, nā adhesives, nā uhi, a me nā ʻoihana ʻē aʻe. ʻO kāna hui kūʻokoʻa o ka solubility, ka pehu ʻana, nā waiwai hana kiʻiʻoniʻoni, a me ka biocompatibility e lilo ia i mea waiwai nui i nā ʻano hana like ʻole, e hāʻawi ana i ka hoʻomohala ʻana i nā huahana hou e kūpono ana i nā pono o nā mākeke like ʻole a me nā mea kūʻai aku.