1. ʻO ka sodium croscarmellose(CMCNa pili kea): he copolymer pili kea o CMCNa
Pono: ka pauka keʻokeʻo a keʻokeʻo paha. Ma muli o ke ʻano o ke keʻa, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai; pehu koke ia i ka wai a hiki i ka 4-8 manawa o kona leo kumu. He maikaʻi ka wai o ka pauka.
Noi: ʻO ia ka super disintegrant i hoʻohana pinepine ʻia. Disintegrant no nā papa waha, capsules, granules.
2. Carmellose calcium (CMCCa i hoʻopili ʻia):
Pono: keʻokeʻo, pauka ʻala ʻole, hygroscopic. 1% solution pH 4.5-6. ʻAneʻane hiki ʻole ke hoʻoheheʻe ʻia i ka ethanol a me ka etera solvent, hiki ʻole ke hoʻoheheʻe ʻia i ka wai, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka waika hydrochloric dilute, hiki ke hoʻoheheʻe ʻia i ka alkali dilute. a i ʻole ka pauda keʻokeʻo. Ma muli o ke ʻano o ke keʻa, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai; pehu ke komo i ka wai.
Hoʻohana: papa disintegrant, binder, diluent.
3. Methylcellulose (MC):
Hoʻolālā: methyl ether o cellulose
Pono: Keʻokeʻo a melemele keʻokeʻo pauka a granules paha. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai wela, ka wai paʻakai saturated, ka waiʻona, ka etera, ka acetone, toluene, chloroform; hiki ke hoʻoheheʻe ʻia i loko o ka glacial acetic acid a i ʻole ka hui like o ka waiʻona a me ka chloroform. Pili ka solubility i loko o ka wai anuanu i ke degere o ka ho'ololi 'ana, a he mea hiki ke ho'ohehe'e 'ia ke degere o ka ho'ololi 'ana he 2.
Ka hoʻohana ʻana: ka mea hoʻopaʻa papa, ka matrix o ka papa disintegrating agent a i ʻole ka hoʻomākaukau hoʻokuʻu mau ʻana, ka ʻaila a i ʻole ka gel, ka mea hoʻopaneʻe a me ka mea mānoanoa, ka uhi ʻana o ka papa, ka emulsion stabilizer.
4. Ethyl cellulose (EC):
Hana: Ethyl ether o cellulose
Nā waiwai: ka pauka keʻokeʻo a melemele-keʻokeʻo a me nā granule. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai, nā wai o ka ʻōpū, glycerol a me propylene glycol. He mea hiki ke hoʻoheheʻe ʻia i loko o ka chloroform a me ka toluene, a hana i kahi ethanol keʻokeʻo.
Noi: ʻO kahi mea lawe wai kūpono ʻole, kūpono e like me ka wai-sensitive drug matrix, wai-insolvable carrier, tablet binder, film material, microcapsule material and sustained-release coating material, etc.
5. Hydroxyethyl Cellulose (HEC):
Hana: ʻāpana hydroxyethyl ether o cellulose.
Nā Pono: ʻO ka pauka melemele māmā a i ʻole ka waiū keʻokeʻo. Hiki ke hoʻoheheʻe ʻia i loko o ka wai anuanu, ka wai wela, ka ʻakika nāwaliwali, ke kumu nāwaliwali, ka ʻakika ikaika, ke kumu ikaika, hiki ʻole ke hoʻoheheʻe ʻia i loko o ka hapa nui o nā mea hoʻoheheʻe kūlohelohe (soluble in dimethyl sulfoxide, dimethylformamide), i nā diol polar organic solvents Hiki ke hoʻonui a hoʻoheheʻe hapa paha.
Noi: Non-ionic wai-soluble mea polymer; nā mānoanoa no ka hoʻomākaukau ophthalmic, otology a me ka hoʻohana topical; HEC i loko o nā lubricants no nā maka maloʻo, nā leka pili a me ka waha maloʻo; hoʻohana ʻia i nā mea hoʻonaninani. Ma keʻano he mea hoʻopaʻa, mea hana kiʻiʻoniʻoni, mea mānoanoa, suspending agent a stabilizer no nā lāʻau lapaʻau a me ka meaʻai, hiki iā ia ke hoʻopili i nā ʻāpana lāʻau lapaʻau, i hiki ai i nā ʻāpana lāʻau ke pāʻani i kahi hana hoʻokuʻu lohi.
6. Hydroxypropyl Cellulose (HPC):
Hoʻokumu: ʻāpana polyhydroxypropyl ether o cellulose
Nā Waiwai: He keʻokeʻo a i ʻole ka pauka melemele iki ka HPC i hoʻololi ʻia. Hiki ke hoʻoheheʻe ʻia i ka methanol, ethanol, propylene glycol, isopropanol, dimethyl sulfoxide a me dimethyl formamide, ʻaʻole hiki ke hoʻoheheʻe ʻia ka mana viscosity kiʻekiʻe. ʻAʻole hiki ke hoʻoheheʻe i ka wai wela, akā hiki ke pehu. ʻO ka hoʻoheheʻe wela: hiki ke hoʻoheheʻe ʻia i ka wai ma lalo o 38°C, gelatinized e ka hoʻomehana ʻana, a hana i ka pehu flocculent ma 40-45°C, hiki ke hoʻihoʻi hou ʻia e ka hoʻoluʻu.
ʻO nā hiʻohiʻona koʻikoʻi L-HPC: hiki ʻole ke hoʻoheheʻe ʻia i ka wai a me nā mea hoʻoheheʻe organik, akā hiki ke ʻā i ka wai, a piʻi ka waiwai pehu me ka piʻi ʻana o nā mea pani.
Hoʻohana: Hoʻohana ʻia ka HPC kiʻekiʻe e like me ka mea hoʻopili papa, granulating agent, film coating material, a hiki ke hoʻohana ʻia e like me ka microencapsulated film material, matrix material a me nā mea kōkua o ka papa hoʻopaʻa ʻana o ka ʻōpū, thickener a me Protective colloids, hoʻohana mau ʻia i nā pā transdermal.
L-HPC: Hoʻohana nui ʻia ma ke ʻano he papa disintegrant a i ʻole kahi mea hoʻopaʻa no ka granulation pulu, ma ke ʻano he papa matrix hoʻokuʻu mau, etc.
7. Hypromellose (HPMC):
Hana: ʻO ka methyl hapa a me kahi hapa polyhydroxypropyl ether o cellulose
Pono: Keʻokeʻo a i ʻole keʻokeʻo keʻokeʻo fibrous a i ʻole ka pauka granular. Hiki ke hoʻoheheʻe ʻia i ka wai anuanu, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka wai wela, a loaʻa iā ia nā waiwai gelation thermal. Hiki ke hoʻoheheʻe ʻia i ka methanol a me ka ethanol solutions, chlorinated hydrocarbons, acetone, a me nā mea ʻē aʻe.
Noi: ʻO kēia huahana he haʻahaʻa haʻahaʻa haʻahaʻa wai i hoʻohana ʻia e like me ka mea uhi kiʻiʻoniʻoni; hoʻohana ʻia kahi mea hoʻoheheʻe organik viscosity kiʻekiʻe e like me ka mea hoʻopaʻa papa, a hiki ke hoʻohana ʻia ka huahana kiʻekiʻe-viscosity e pale i ka matrix hoʻokuʻu o nā lāʻau hoʻoheheʻe wai; e like me ka kulu maka mānoanoa no ka lacquer a me nā waimaka hana, a me ka mea pulu no nā lens pili.
8. Hypromellose Phthalate (HPMCP):
Hana: ʻO HPMCP ka phthalic acid half ester o HPMC.
Nā Pono: ʻO ka beige a keʻokeʻo paha a i ʻole granules. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai a me ka waiʻawaʻawa, ʻaʻole hiki ke hoʻoheheʻe ʻia i ka hexane, akā hiki ke hoʻoheheʻe ʻia i ka acetone: methanol, acetone: ethanol a i ʻole methanol: ka hui ʻana o ka chloromethane.
Noi: He ʻano mea hoʻouhi hou me ka hana maikaʻi loa, hiki ke hoʻohana ʻia e like me ka uhi kiʻiʻoniʻoni e uhi i ka ʻala o nā papa a i ʻole granules.
9. Hypromellose Acetate Succinate (HPMCAS):
Hoʻokumu: hui ʻia nā esters acetic a me succinic oHPMC
Pono: Keʻokeʻo a melemele keʻokeʻo pauka a granules paha. Hiki ke hoʻoheheʻe ʻia i loko o ka solution sodium hydroxide a me ka sodium carbonate, hiki ke hoʻoheheʻe ʻia i ka acetone, methanol a i ʻole ethanol: wai, dichloromethane: hui ʻia ethanol, hiki ʻole ke hoʻoheheʻe ʻia i ka wai, ethanol a me ka etera.
Noi: E like me ka mea hoʻopaʻa papa enteric, mea hoʻokuʻu hoʻokuʻu mau a me nā mea uhi kiʻiʻoniʻoni.
10. ʻAgar:
Ka Papa Hana: ʻO Agar ka hui ʻana o ʻelua polysaccharides ma kahi o 60-80% neutral agarose a me 20-40% agarose. Hoʻokumu ʻia ʻo Agarose me nā ʻāpana hana hou o ka agarobiose i hoʻopili ʻia ʻo D-galactopyranosose a me L-galactopyranosose ma 1-3 a me 1-4.
Nā Pono: He translucent ʻo Agar, ʻoi aku ka māmā melemele square cylinder, slender strip a scaly flake a i ʻole pauda. ʻAʻole hiki ke hoʻoheheʻe ʻia i ka wai anuanu, hiki ke hoʻoheheʻe ʻia i ka wai paila. Pehu 20 manawa i ka wai anuanu.
Noi: E like me ka mea hoʻopaʻa paʻa, ka ʻaila base, suppository base, emulsifier, stabilizer, suspending agent, a me ka poultice, capsule, syrup, jelly a me ka emulsion.
Ka manawa hoʻouna: Apr-26-2024