He aha ka pH hiki ke hoʻoheheʻe ʻia ka HPMC

Hydroxypropyl methylcellulose (HPMC)he polymer maʻamau i hoʻohana ʻia i nā lāʻau lapaʻau, nā mea hoʻonaninani, a me nā huahana meaʻai. Aia kona solubility i nā kumu like ʻole, me ka pH. ʻO ka maʻamau, hiki ke hoʻoheheʻe ʻia ka HPMC ma nā kūlana acidic a me ka alkaline, akā hiki ke hoʻololi ʻia kona solubility ma muli o ke degere o ka hoʻololi ʻana (DS) a me ke kaumaha molekala (MW) o ka polymer.

Ma nā kūlana acidic, hōʻike pinepine ʻo HPMC i ka solubility maikaʻi ma muli o ka protonation o kāna mau pūʻulu hydroxyl, e hoʻonui ai i kona hydration a me ka dispersibility. Hoʻonui ka solubility o HPMC i ka emi ʻana o ka pH ma lalo o kona pKa, aia ma kahi o 3.5-4.5 ma muli o ke ʻano o ka hoʻololi ʻana.

ʻO ka mea ʻē aʻe, ma nā kūlana alkaline, hiki ke hoʻoheheʻe ʻia ka HPMC, ʻoi aku ka nui o nā waiwai pH kiʻekiʻe. Ma ka pH alkaline, hiki mai ka deprotonation o nā pūʻulu hydroxyl, e alakaʻi ana i ka hoʻonui ʻana i ka solubility ma o ka hoʻopaʻa ʻana i ka hydrogen me nā mole wai.

Eia nō naʻe, he mea nui e hoʻomaopopo i ka pH pololei i hiki ke hoʻoheheʻe ʻia ka HPMC ma muli o ka pae kikoʻī o HPMC, kona degere o ka hoʻololi ʻana, a me kona kaumaha molekala. ʻO ka maʻamau, hōʻike nā māka HPMC me nā kiʻekiʻe kiʻekiʻe o ka hoʻololi ʻana a me nā kaumaha molekala haʻahaʻa e hōʻike i ka solubility maikaʻi ma nā koina pH haʻahaʻa.

I loko o nā papa hana lāʻau lapaʻau,HPMChoʻohana pinepine ʻia ma ke ʻano he kiʻiʻoniʻoni mua, mānoanoa, a i ʻole stabilizer. He mea koʻikoʻi kona ʻano solubility no ka mālama ʻana i nā profiles release drug, viscosity of formulations, a me ke kūpaʻa o nā emulsions a i ʻole ka hoʻokuʻu ʻia.

ʻOiai hiki ke hoʻoheheʻe ʻia ka HPMC ma kahi ākea pH ākea, hiki ke hoʻoponopono maikaʻi ʻia kona ʻano solubility ma ka hoʻoponopono ʻana i ka pH o ka hopena a me ke koho ʻana i ka māka kūpono o HPMC ma muli o ka noi i makemake ʻia.