Hydroxypropyl methyl cellulose HPMC, ko te hydroxypromellose hoki, he ma ki te ma-kore-ma te cellulose ether paura, he granule ranei he wai matao te wairewa me te wai wera he rite ki te methyl cellulose. Ko te roopu Hydroxypropyl me te roopu methyl he here ether me te mowhiti huka o te cellulose te whakakotahitanga, he ahua o te cellulose kore-katote etere whakauru. He waerau hangarua, hohekore, viscoelastic e whakamahia nuitia ana hei whakahinuhinu i roto i nga mahi ophthalmology, hei whakangao, hei awhina ranei i nga rongoa waha.
1. Te tukanga whakaputa
Kraft penupenu ki te ihirangi αcellulose o 97%, pokey o roto o 720mL /g me te roa muka toharite o 2.6mm i waiwaitia i roto i te 49% NaOH otinga i 40 ℃ mō te 50 hēkona. Katahi ka peia te penupenu ki te tango i te taikaha 49% otinga NaOH ki te tiki cellulose alkali. Ko te tauwehenga taumaha o te (49% NaOH wairewa wai) ki (waahanga totoka o te penupenu) i roto i te taahiraa impregnation he 200. Ko te tauwehenga taumaha o te NaOH i roto i te cellulose alkali ki te totoka i roto i te penupenu he 1.49. Ko te cellulose alkali (20kg) ka tukuna ki roto i te reactor pehanga me te whakakorikori o roto, katahi ka whakakoruatia, ka purea ki te hauota kia tika te tango i te hāora mai i te reactor. Na, ka whakahaeretia te pāmahana i roto i te reactor i te 60 ℃ i te wa e mahia ana te whakaoho o roto.
Katahi ka taapirihia te 2.4kg dME me te whakamahana i roto i te reactor ki te 60 ℃. I muri i te tapiritanga o te dimethyl ether, ka tapirihia te methylene chloride ki te hanga i te owehenga molar o te methylene chloride ki te NaOH i roto i te cellulose alkaline 1.3, i tapirihia te propylene oxide ki te hanga i te tauwehenga taimaha o te propylene oxide ki te totoka i roto i te penupenu 1.97, ka whakahaeretia te pāmahana i roto i te reactor mai i te 60 ℃ ki te 80 ℃. Whai muri i te taapiri i te chloromethane me te propylene oxide, ka whakahaeretia te pāmahana i roto i te reactor mai i te 80 ℃ ki te 90 ℃. I tua atu, ka roa te tauhohenga mo te 20 meneti i te 90 ℃.
Ka whakahekehia te hau mai i te reactor, ka tangohia te makuku hydroxypropyl methyl cellulose i te reactor. Ko te pāmahana o te hydroxypropyl methyl cellulose he 62 ℃. Te ine i te 50% te rahi o te matūriki i roto i te tohanga rahi matūriki i runga i te taumaha i runga i te ōwehenga o te hydroxypropyl methyl cellulose ma nga kohao o te tatari e rima, he rereke te rahi o ia tuwhera.
Ko te mutunga, ko te rahi o te matūriki toharite o nga matūriki taratara he 6.2mm. Ko te maru hydroxypropyl methyl cellulose i whakaurua ki roto i te kneader biaxial tonu (KRC kneader S1, L/D = 10.2, rōrahi ā-0.12 L, tere hurihanga 150rpm) i te tere o te 10kg/hr, a ka riro mai i te pirau hydroxypropyl methyl cellulose. Ko te hua o nga inenga rite ki te whakamahi i nga mata e 5 me nga rahi tuwhera rereke, ko te rahi o te matūriki toharite he 1.4mm. Te taapiri i te 80 ℃ te wai wera ki te pirau hydroxypropyl methyl cellulose kua pirau i roto i te tank me te mana pāmahana o te koti. ko te nui o te tauwehenga taumaha o te hydroxypropyl methyl cellulose kua pirau ki te tapeke o te slurry he 0.1, ka riro mai te slurry. I whakakorikoria te slurry i te pāmahana 80 ℃ mo te 60 meneti.
Na, ka tukuna te slurry ki te tere hurihuri o te 0.5 RPM me te tātari pehanga hurihuri i mua i te whakamahana (nga hua BHS Sonthofen). Ko te pāmahana o te grout he 93 ℃. Whakamahia he papu ki te tuku slurry, he 0.2mpa te pehanga tuku papu. Ko te rahi o te whakatuwheratanga o te tātari pehanga hurihuri ko 80μm, a ko te waahi tātari he 0.12m2. Ko te slurry i tukuna ki te tātari pehanga hurihuri ka tātarihia ma te tātari ka huri hei keke tātari. Ko te keke tātari ka tukuna ki te 0.3mpa mamaoa me te 95 ℃ te wai wera me te tauwehenga taumaha o te 10.0 ki te wahanga totoka o te HYDROXYpropyl methyl cellulose kua horoia, ka tohua ma te tātari.
Ko te wai wera ka tukuna ma te papu i te pehanga tuku o te 0.2mpa. Whai muri i te toha wai wera, ka tukuna te mamaoa 0.3mpa. Na, i muri i te horoinga o nga hua ka tangohia mai i te mata tātari e te kirikiri ka tukuna ki waho o te miihini horoi. Ko nga hikoinga mai i te tuku slurry ki te tuku i nga hua horoi ka mahia tonutia. I te ine ma te whakamahi i te whakamaroke whakamaroke i te wera, he 52.8%. Ko nga hua i horoia i tukuna mai i te tātari pehanga hurihuri i whakamarokehia e te whakamaroke hau i te 80 ℃, ka kuru i roto i te mira Victory ki te whiwhi hydroxypropyl methyl cellulose.
2.Te tono
HPMCwhakamahia te hua hei thickener, dispersant, binder, emulsifier me te stabilizer i roto i te ahumahi pueru. Ka whakamahia hoki i roto i te kapia waihanga, petrochemical, uku, pepa, hiako, rongoa, kai, whakapaipai me etahi atu ahumahi.
Te wa tuku: Apr-26-2024